Liposomal nanosystems in rheumatoid arthritis

Bibliographic Details
Main Author: Ferreira-Silva, Margarida
Publication Date: 2021
Other Authors: Faria-Silva, Catarina, Baptista, Pedro Viana, Fernandes, Eduarda, Fernandes, Alexandra Ramos, Corvo, Maria Luísa
Format: Other
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/124888
Summary: This work received financial support from PT national funds from Fundacao para a Ciencia e Tecnologia (FCT) through the grant FCT/MEC (UID/DTP/04138/2020 and UIDP/04138/2020) financing Research Institute for Medicines-iMed. ULisboa, grant FCT/MEC (UIDP/04378/2020 and UIDB/04378/2020) financing Applied Molecular Biosciences Unit-UCIBIO, a grant by FCT/MCTES (UIDB/50006/2020) financing LAQV-REQUIMTE Associate Laboratory, from the European Union (FEDER funds through COMPETE POCI-01-0145-FEDER-029253), and by Phospholipid Research Center (project LCO-2017-052/1-1). M.F.-S. acknowledges PhD grant PD/BD/135,264/2017 attributed by the FCT i3DU PhD program.
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spelling Liposomal nanosystems in rheumatoid arthritisActive targetingDrug delivery nanosystemsLiposomesPassive targetingRheumatoid arthritisPharmaceutical ScienceSDG 3 - Good Health and Well-beingThis work received financial support from PT national funds from Fundacao para a Ciencia e Tecnologia (FCT) through the grant FCT/MEC (UID/DTP/04138/2020 and UIDP/04138/2020) financing Research Institute for Medicines-iMed. ULisboa, grant FCT/MEC (UIDP/04378/2020 and UIDB/04378/2020) financing Applied Molecular Biosciences Unit-UCIBIO, a grant by FCT/MCTES (UIDB/50006/2020) financing LAQV-REQUIMTE Associate Laboratory, from the European Union (FEDER funds through COMPETE POCI-01-0145-FEDER-029253), and by Phospholipid Research Center (project LCO-2017-052/1-1). M.F.-S. acknowledges PhD grant PD/BD/135,264/2017 attributed by the FCT i3DU PhD program.Rheumatoid arthritis (RA) is an autoimmune disease that affects the joints and results in reduced patient quality of life due to its chronic nature and several comorbidities. RA is also associated with a high socioeconomic burden. Currently, several available therapies minimize symptoms and prevent disease progression. However, more effective treatments are needed due to current therapies’ severe side-effects, especially under long-term use. Drug delivery systems have demonstrated their clinical importance—with several nanocarriers present in the market—due to their capacity to improve therapeutic drug index, for instance, by enabling passive or active targeting. The first to achieve market authorization were liposomes that still represent a considerable part of approved delivery systems. In this manuscript, we review the role of liposomes in RA treatment, address preclinical studies and clinical trials, and discuss factors that could hamper a successful clinical translation. We also suggest some alterations that could potentially improve their progression to the market.DCV - Departamento de Ciências da VidaUCIBIO - Applied Molecular Biosciences UnitRUNFerreira-Silva, MargaridaFaria-Silva, CatarinaBaptista, Pedro VianaFernandes, EduardaFernandes, Alexandra RamosCorvo, Maria Luísa2021-09-21T01:53:53Z2021-042021-04-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/otherapplication/pdfhttp://hdl.handle.net/10362/124888eng1999-4923PURE: 29313858https://doi.org/10.3390/pharmaceutics13040454info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T17:56:14Zoai:run.unl.pt:10362/124888Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:27:28.325639Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Liposomal nanosystems in rheumatoid arthritis
title Liposomal nanosystems in rheumatoid arthritis
spellingShingle Liposomal nanosystems in rheumatoid arthritis
Ferreira-Silva, Margarida
Active targeting
Drug delivery nanosystems
Liposomes
Passive targeting
Rheumatoid arthritis
Pharmaceutical Science
SDG 3 - Good Health and Well-being
title_short Liposomal nanosystems in rheumatoid arthritis
title_full Liposomal nanosystems in rheumatoid arthritis
title_fullStr Liposomal nanosystems in rheumatoid arthritis
title_full_unstemmed Liposomal nanosystems in rheumatoid arthritis
title_sort Liposomal nanosystems in rheumatoid arthritis
author Ferreira-Silva, Margarida
author_facet Ferreira-Silva, Margarida
Faria-Silva, Catarina
Baptista, Pedro Viana
Fernandes, Eduarda
Fernandes, Alexandra Ramos
Corvo, Maria Luísa
author_role author
author2 Faria-Silva, Catarina
Baptista, Pedro Viana
Fernandes, Eduarda
Fernandes, Alexandra Ramos
Corvo, Maria Luísa
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv DCV - Departamento de Ciências da Vida
UCIBIO - Applied Molecular Biosciences Unit
RUN
dc.contributor.author.fl_str_mv Ferreira-Silva, Margarida
Faria-Silva, Catarina
Baptista, Pedro Viana
Fernandes, Eduarda
Fernandes, Alexandra Ramos
Corvo, Maria Luísa
dc.subject.por.fl_str_mv Active targeting
Drug delivery nanosystems
Liposomes
Passive targeting
Rheumatoid arthritis
Pharmaceutical Science
SDG 3 - Good Health and Well-being
topic Active targeting
Drug delivery nanosystems
Liposomes
Passive targeting
Rheumatoid arthritis
Pharmaceutical Science
SDG 3 - Good Health and Well-being
description This work received financial support from PT national funds from Fundacao para a Ciencia e Tecnologia (FCT) through the grant FCT/MEC (UID/DTP/04138/2020 and UIDP/04138/2020) financing Research Institute for Medicines-iMed. ULisboa, grant FCT/MEC (UIDP/04378/2020 and UIDB/04378/2020) financing Applied Molecular Biosciences Unit-UCIBIO, a grant by FCT/MCTES (UIDB/50006/2020) financing LAQV-REQUIMTE Associate Laboratory, from the European Union (FEDER funds through COMPETE POCI-01-0145-FEDER-029253), and by Phospholipid Research Center (project LCO-2017-052/1-1). M.F.-S. acknowledges PhD grant PD/BD/135,264/2017 attributed by the FCT i3DU PhD program.
publishDate 2021
dc.date.none.fl_str_mv 2021-09-21T01:53:53Z
2021-04
2021-04-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/other
format other
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/124888
url http://hdl.handle.net/10362/124888
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1999-4923
PURE: 29313858
https://doi.org/10.3390/pharmaceutics13040454
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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