Enthesitis in a European registry-based cohort of patients with psoriatic arthritis treated with tumour necrosis factor inhibitors
| Main Author: | |
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| Publication Date: | 2024 |
| Other Authors: | , , , , , , , , , , , , , , , , , , |
| Format: | Article |
| Language: | eng |
| Source: | Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
| Download full: | http://hdl.handle.net/10362/167903 |
Summary: | Funding Information: The EuroSpA Research Collaboration Network was financially supported by Novartis Pharma AG. Novartis did not influence data collection, statistical analyses, manuscript preparation or decision to submit the manuscript. The outline of was drawn by Mr Rajkumar, Department of Anatomy, Christian Medical College, Vellore, India. Publisher Copyright: © 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. |
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Enthesitis in a European registry-based cohort of patients with psoriatic arthritis treated with tumour necrosis factor inhibitorsclinical burden, patient-reported outcomes, and treatment responseRheumatologyImmunology and AllergyImmunologyFunding Information: The EuroSpA Research Collaboration Network was financially supported by Novartis Pharma AG. Novartis did not influence data collection, statistical analyses, manuscript preparation or decision to submit the manuscript. The outline of was drawn by Mr Rajkumar, Department of Anatomy, Christian Medical College, Vellore, India. Publisher Copyright: © 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.Objective: To explore the registration of enthesitis among biologic-naïve patients with psoriatic arthritis (PsA) initiating tumour necrosis factor inhibitor (TNFi) treatment across 12 European registries, compare the disease burden and patient-reported outcomes (PROs) between patients with and without enthesitis, and assess the enthesitis treatment response. Method: Demographics, clinical characteristics, and PROs at first TNFi (TNFi-1) initiation (baseline) were assessed in patients with PsA, diagnosed by a rheumatologist, with versus without assessment of entheses and between those with versus without enthesitis. Enthesitis scores and resolution frequency were identified at follow-up. Results: Of 10 547 patients in the European Spondyloarthritis (EuroSpA) Research Collaboration Network initiating TNFi, 1357 underwent evaluation for enthesitis. Eight registries included a validated scoring system for enthesitis. At baseline, 874 patients underwent entheses assessment [Maastricht Ankylosing Spondylitis Enthesitis Score (MASES) 485 patients, Spondyloarthritis Research Consortium of Canada (SPARCC) 389 patients]. Enthesitis was detected by MASES in 170/485 (35%, mean score ± sd 3.1 ± 2.4) and by SPARCC in 236/389 (61%, 4 ± 3.4). Achilles enthesitis was most frequent, by both MASES (unilateral/bilateral 28%/9%) and SPARCC (48%/18%). MASES/SPARCC baseline and follow-up scores for TNFi-1 were available for 100/105 patients. Of these, 63 patients (63%) (MASES) and 46 (43.8%) (SPARCC) achieved resolution of enthesitis. The site-specific enthesitis resolution was overall lower at SPARCC sites (peripheral; 63–80%) than at MASES sites (mainly axial; 82–100%) following TNFi-1. Disease activity and PROs were worse in patients with versus without enthesitis. Conclusion: Entheseal assessments are only registered in a minority of patients with PsA in routine care. When assessed, enthesitis was common, and a substantial proportion demonstrated resolution following treatment with TNFi-1.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNMathew, A. J.Lund, M. L.Pedersen, M. P.Rasmussen, S. H.Glintborg, B.Loft, A. G.Nissen, M. J.Möller, B.Rodrigues, A. M.Santos, F. P.Rotar, Z.Tomšič, M.Relas, H.Peltomaa, R.Gudbjornsson, B.Löve, T. J.Kocaer, S. B.Koken Avsar, A.Midtbøll Ørnbjerg, L.Østergaard, M.2024-05-28T00:33:36Z2024-052024-05-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/167903eng0300-9742PURE: 91985889https://doi.org/10.1080/03009742.2024.2336743info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-02-24T01:40:01Zoai:run.unl.pt:10362/167903Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:54:58.405501Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse |
| dc.title.none.fl_str_mv |
Enthesitis in a European registry-based cohort of patients with psoriatic arthritis treated with tumour necrosis factor inhibitors clinical burden, patient-reported outcomes, and treatment response |
| title |
Enthesitis in a European registry-based cohort of patients with psoriatic arthritis treated with tumour necrosis factor inhibitors |
| spellingShingle |
Enthesitis in a European registry-based cohort of patients with psoriatic arthritis treated with tumour necrosis factor inhibitors Mathew, A. J. Rheumatology Immunology and Allergy Immunology |
| title_short |
Enthesitis in a European registry-based cohort of patients with psoriatic arthritis treated with tumour necrosis factor inhibitors |
| title_full |
Enthesitis in a European registry-based cohort of patients with psoriatic arthritis treated with tumour necrosis factor inhibitors |
| title_fullStr |
Enthesitis in a European registry-based cohort of patients with psoriatic arthritis treated with tumour necrosis factor inhibitors |
| title_full_unstemmed |
Enthesitis in a European registry-based cohort of patients with psoriatic arthritis treated with tumour necrosis factor inhibitors |
| title_sort |
Enthesitis in a European registry-based cohort of patients with psoriatic arthritis treated with tumour necrosis factor inhibitors |
| author |
Mathew, A. J. |
| author_facet |
Mathew, A. J. Lund, M. L. Pedersen, M. P. Rasmussen, S. H. Glintborg, B. Loft, A. G. Nissen, M. J. Möller, B. Rodrigues, A. M. Santos, F. P. Rotar, Z. Tomšič, M. Relas, H. Peltomaa, R. Gudbjornsson, B. Löve, T. J. Kocaer, S. B. Koken Avsar, A. Midtbøll Ørnbjerg, L. Østergaard, M. |
| author_role |
author |
| author2 |
Lund, M. L. Pedersen, M. P. Rasmussen, S. H. Glintborg, B. Loft, A. G. Nissen, M. J. Möller, B. Rodrigues, A. M. Santos, F. P. Rotar, Z. Tomšič, M. Relas, H. Peltomaa, R. Gudbjornsson, B. Löve, T. J. Kocaer, S. B. Koken Avsar, A. Midtbøll Ørnbjerg, L. Østergaard, M. |
| author2_role |
author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
| dc.contributor.author.fl_str_mv |
Mathew, A. J. Lund, M. L. Pedersen, M. P. Rasmussen, S. H. Glintborg, B. Loft, A. G. Nissen, M. J. Möller, B. Rodrigues, A. M. Santos, F. P. Rotar, Z. Tomšič, M. Relas, H. Peltomaa, R. Gudbjornsson, B. Löve, T. J. Kocaer, S. B. Koken Avsar, A. Midtbøll Ørnbjerg, L. Østergaard, M. |
| dc.subject.por.fl_str_mv |
Rheumatology Immunology and Allergy Immunology |
| topic |
Rheumatology Immunology and Allergy Immunology |
| description |
Funding Information: The EuroSpA Research Collaboration Network was financially supported by Novartis Pharma AG. Novartis did not influence data collection, statistical analyses, manuscript preparation or decision to submit the manuscript. The outline of was drawn by Mr Rajkumar, Department of Anatomy, Christian Medical College, Vellore, India. Publisher Copyright: © 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. |
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2024 |
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2024-05-28T00:33:36Z 2024-05 2024-05-01T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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http://hdl.handle.net/10362/167903 |
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http://hdl.handle.net/10362/167903 |
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eng |
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eng |
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0300-9742 PURE: 91985889 https://doi.org/10.1080/03009742.2024.2336743 |
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