A Rare Malignancy in the Post -Transplant Period: Myeloma Cast Nephropathy

• Main Author: Mesquita, I
• Publication Date: 2016
• Other Authors: Viana, H, Possante, M, João, C, Carvalho, S, Silva, C, Aires, I, Ferreira, A, Remédio, F, Carvalho, F, Nolasco, F
• Format: Article
• Language: eng
• Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
• Download full: http://hdl.handle.net/10400.17/3128
• topic: Kidney Transplantation; Myeloma; Post-Transplant; Nephropathy; HCC NEF

Myeloma-associated renal disorders are rare events among renal transplants and can occur as recurrent or de novo disease. We describe an unusual case of renal allograft dysfunction due to myeloma cast nephropathy occurring 19 years after having received a renal transplant in a patient with no prior history of multiple myeloma or monoclonal gammopathy preceding transplantation. Our patient was treated with five cycles of chemotheraphy(bortezomib, melphalan and steroids), which resulted in short-term improvement in allograft dysfunction and complete haematological remission. The longer patient and graft survival after renal transplantation make post-transplant lymphoproliferative disease more frequent. Multiple myeloma after kidney transplant is rare and an elevated index of suspicion is necessary to make a timely diagnosis of this serious disease. Further work is needed to identify the best treatment options for these patients.