The importance of balance between flexibility and neuronal stability in memory formation

Bibliographic Details
Main Author: Calafate, Sara Cesariny
Publication Date: 2021
Format: Article
Language: por
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: https://doi.org/10.23882/NE2146
Summary: The neurobiological mechanisms behind memory formation remain unknown. Synapses are essential neuronal sub-compartments for the transmission of information within neuronal networks. Hebbian and homeostatic plasticity mechanisms, are two types of processes that play a role on synaptic modifications during the formation of memories. The interaction between these types of plasticity controls the balance between neuronal flexibility and stability to keep neuronal activity within a physiological window. Thus, it is important to better understand these mechanisms and identify the basic units of this system as they may be involved in the onset of neurological disorders. Here, I shed light on the impact of these mechanisms in the early phase of Alzheimer’s disease.
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spelling The importance of balance between flexibility and neuronal stability in memory formationA importância do equilíbrio entre flexibilidade e estabilidade neuronal na formação de memóriasdoença de Alzheimerplasticidade hebbianaplasticidade homeostáticaredes neuronaissinapseAlzheimer’s diseasehebbian plasticityhomeostatic plasticityneuronal networkssynapseThe neurobiological mechanisms behind memory formation remain unknown. Synapses are essential neuronal sub-compartments for the transmission of information within neuronal networks. Hebbian and homeostatic plasticity mechanisms, are two types of processes that play a role on synaptic modifications during the formation of memories. The interaction between these types of plasticity controls the balance between neuronal flexibility and stability to keep neuronal activity within a physiological window. Thus, it is important to better understand these mechanisms and identify the basic units of this system as they may be involved in the onset of neurological disorders. Here, I shed light on the impact of these mechanisms in the early phase of Alzheimer’s disease.Os mecanismos neurobiológicos essenciais para a formação de memórias são ainda pouco compreendidos. No entanto, sabe-se que as sinapses, sub-compartimentos neuronais essenciais para a transmissão de informação nas redes neuronais, são elementos imprescindíveis para este processo. Diferentes formas de plasticidade (hebbiano e homeostáticos) estão na base de modificações sinápticas que acontecem durante a formação de memórias. A interação destes mecanismos controlam o equilíbrio entre a flexibilidade e a estabilidade neuronal mantendo assim a sua actividade dentro de uma janela fisiológica. É, portanto, necessário conhecer melhor estes mecanismos de plasticidade e assim identificar que tipo de alterações nas unidades básicas deste sistema podem estar na origem de distúrbios do funcionamento do cérebro. Neste artigo, reflito sobre a potencial implicação destas alterações nas fases iniciais da doença de Alzheimer.NMd, Núcleo Multidisciplinar2021-07-07info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://doi.org/10.23882/NE2146https://doi.org/10.23882/NE2146[RMd] RevistaMultidisciplinar; Vol. 3 No. 2 (2021): Neuroscience and Education; 5-11[RMd] RevistaMultidisciplinar; Vol. 3 Núm. 2 (2021): Neurociências e Educação; 5-11[RMd] Revue Multidisciplinaire; Vol. 3 No 2 (2021): Neurociências e Educação; 5-11[RMd] RevistaMultidisciplinar; Vol. 3 N.º 2 (2021): Neurociências e Educação; 5-112184-549210.23882/v3n2reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAPporhttps://revistamultidisciplinar.com/index.php/oj/article/view/66https://revistamultidisciplinar.com/index.php/oj/article/view/66/65Direitos de Autor (c) 2021 Sara Cesariny Calafateinfo:eu-repo/semantics/openAccessCalafate, Sara Cesariny2025-04-12T08:13:08Zoai:ojs2.revistamultidisciplinar.com:article/66Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T06:24:59.205958Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv The importance of balance between flexibility and neuronal stability in memory formation
A importância do equilíbrio entre flexibilidade e estabilidade neuronal na formação de memórias
title The importance of balance between flexibility and neuronal stability in memory formation
spellingShingle The importance of balance between flexibility and neuronal stability in memory formation
Calafate, Sara Cesariny
doença de Alzheimer
plasticidade hebbiana
plasticidade homeostática
redes neuronais
sinapse
Alzheimer’s disease
hebbian plasticity
homeostatic plasticity
neuronal networks
synapse
title_short The importance of balance between flexibility and neuronal stability in memory formation
title_full The importance of balance between flexibility and neuronal stability in memory formation
title_fullStr The importance of balance between flexibility and neuronal stability in memory formation
title_full_unstemmed The importance of balance between flexibility and neuronal stability in memory formation
title_sort The importance of balance between flexibility and neuronal stability in memory formation
author Calafate, Sara Cesariny
author_facet Calafate, Sara Cesariny
author_role author
dc.contributor.author.fl_str_mv Calafate, Sara Cesariny
dc.subject.por.fl_str_mv doença de Alzheimer
plasticidade hebbiana
plasticidade homeostática
redes neuronais
sinapse
Alzheimer’s disease
hebbian plasticity
homeostatic plasticity
neuronal networks
synapse
topic doença de Alzheimer
plasticidade hebbiana
plasticidade homeostática
redes neuronais
sinapse
Alzheimer’s disease
hebbian plasticity
homeostatic plasticity
neuronal networks
synapse
description The neurobiological mechanisms behind memory formation remain unknown. Synapses are essential neuronal sub-compartments for the transmission of information within neuronal networks. Hebbian and homeostatic plasticity mechanisms, are two types of processes that play a role on synaptic modifications during the formation of memories. The interaction between these types of plasticity controls the balance between neuronal flexibility and stability to keep neuronal activity within a physiological window. Thus, it is important to better understand these mechanisms and identify the basic units of this system as they may be involved in the onset of neurological disorders. Here, I shed light on the impact of these mechanisms in the early phase of Alzheimer’s disease.
publishDate 2021
dc.date.none.fl_str_mv 2021-07-07
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://doi.org/10.23882/NE2146
https://doi.org/10.23882/NE2146
url https://doi.org/10.23882/NE2146
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://revistamultidisciplinar.com/index.php/oj/article/view/66
https://revistamultidisciplinar.com/index.php/oj/article/view/66/65
dc.rights.driver.fl_str_mv Direitos de Autor (c) 2021 Sara Cesariny Calafate
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Direitos de Autor (c) 2021 Sara Cesariny Calafate
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv NMd, Núcleo Multidisciplinar
publisher.none.fl_str_mv NMd, Núcleo Multidisciplinar
dc.source.none.fl_str_mv [RMd] RevistaMultidisciplinar; Vol. 3 No. 2 (2021): Neuroscience and Education; 5-11
[RMd] RevistaMultidisciplinar; Vol. 3 Núm. 2 (2021): Neurociências e Educação; 5-11
[RMd] Revue Multidisciplinaire; Vol. 3 No 2 (2021): Neurociências e Educação; 5-11
[RMd] RevistaMultidisciplinar; Vol. 3 N.º 2 (2021): Neurociências e Educação; 5-11
2184-5492
10.23882/v3n2
reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833602678074114048

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