Metastatic Non-Small Cell Lung Carcinoma treated with immunotherapy+ chemotherapy: a case of dissociated response?

• Main Author: Gigante, Ana Rita
• Publication Date: 2024
• Other Authors: Marques, Inês, Sanches, Agostinho, Dias, Margarida, Barroso, Ana
• Format: Article
• Language: por
• Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
• Download full: https://doi.org/10.32932/gecp.2022.09.024
• topic: Non-Small Cell Lung Carcinoma; Immunotherapy; Response Assessment; Carcinoma Pulmão Não Pequenas células; Imunoterapia; Avaliação resposta

Assessment of response to systemic therapy can be challenging in mNSCLC, especially with immunotherapy, due to the possibility of atypical response patterns. We report a case of metastatic lung adenocarcinoma under immunotherapy and chemotherapy with an apparent response dissociated in a pulmonary nodule, whose biopsy of the non-responsive lesion revealed a histological diagnosis different from the primary tumour. When there is a discrepancy in the type of response to systemic treatment of two different target lesions, it should be considered the possibility of a second primary tumour. The histopathological and/or molecular diagnosis confirmation is crucial for (re)staging, treatment decisions, and patient prognosis.