Lower serum magnesium levels are associated with a higher risk of fractures and vascular calcifications in hemodialysis patients

Bibliographic Details
Main Author: Matias, Patrícia João
Publication Date: 2025
Other Authors: Ávila, Gonçalo, Domingos, Diogo, Gil, Célia, Ferreira, Aníbal
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/178237
Summary: Publisher Copyright: © The Author(s) 2024.
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network_acronym_str RCAP
network_name_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository_id_str https://opendoar.ac.uk/repository/7160
spelling Lower serum magnesium levels are associated with a higher risk of fractures and vascular calcifications in hemodialysis patientsbone fractureshemodialysismagnesiumsecondary hyperparathyroidismvascular calcificationsNephrologyTransplantationSDG 3 - Good Health and Well-beingPublisher Copyright: © The Author(s) 2024.Background. Magnesium (Mg) deficiency seems to be associated with altered bone metabolism and vascular calcifications (VC). This study aimed to evaluate the association between serum Mg levels and incident bone fragility fractures and VC in a cohort of prevalent hemodialysis (HD) patients. Methods. We performed a retrospective study of 206 patients, with a mean age of 68.3 ± 13.1 years; 121 (59%) were male, and the median follow-up time was 58 months. Results. Thirty-seven episodes of fragility fractures were identified with a median HD vintage of 42 months—an incidence rate of 29 per 1000 person-years. Patients with fractures showed lower Mg levels compared with those without fractures (P < .001) and more VC (P = .01). In a Cox regression analysis, time to fragility fracture was independently associated with serum Mg <2.2 mg/dL (P < .001), in a model adjusted to age, female gender, HD vintage, diabetes mellitus, body mass index, albumin, parathyroid hormone, active vitamin D therapy and the presence of VC. Patients with Mg serum levels <2.2 mg/dL had a 1.32-fold higher risk of fragility fractures (P < .001). Conclusions. This study showed that the incidence of bone fragility fractures in HD patients is high and is significantly associated with lower Mg levels and with the presence of more VC.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNMatias, Patrícia JoãoÁvila, GonçaloDomingos, DiogoGil, CéliaFerreira, Aníbal2025-01-31T21:15:25Z2025-01-012025-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/178237eng2048-8505PURE: 108260289https://doi.org/10.1093/ckj/sfae381info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-02-10T01:37:20Zoai:run.unl.pt:10362/178237Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T19:46:20.313594Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Lower serum magnesium levels are associated with a higher risk of fractures and vascular calcifications in hemodialysis patients
title Lower serum magnesium levels are associated with a higher risk of fractures and vascular calcifications in hemodialysis patients
spellingShingle Lower serum magnesium levels are associated with a higher risk of fractures and vascular calcifications in hemodialysis patients
Matias, Patrícia João
bone fractures
hemodialysis
magnesium
secondary hyperparathyroidism
vascular calcifications
Nephrology
Transplantation
SDG 3 - Good Health and Well-being
title_short Lower serum magnesium levels are associated with a higher risk of fractures and vascular calcifications in hemodialysis patients
title_full Lower serum magnesium levels are associated with a higher risk of fractures and vascular calcifications in hemodialysis patients
title_fullStr Lower serum magnesium levels are associated with a higher risk of fractures and vascular calcifications in hemodialysis patients
title_full_unstemmed Lower serum magnesium levels are associated with a higher risk of fractures and vascular calcifications in hemodialysis patients
title_sort Lower serum magnesium levels are associated with a higher risk of fractures and vascular calcifications in hemodialysis patients
author Matias, Patrícia João
author_facet Matias, Patrícia João
Ávila, Gonçalo
Domingos, Diogo
Gil, Célia
Ferreira, Aníbal
author_role author
author2 Ávila, Gonçalo
Domingos, Diogo
Gil, Célia
Ferreira, Aníbal
author2_role author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Matias, Patrícia João
Ávila, Gonçalo
Domingos, Diogo
Gil, Célia
Ferreira, Aníbal
dc.subject.por.fl_str_mv bone fractures
hemodialysis
magnesium
secondary hyperparathyroidism
vascular calcifications
Nephrology
Transplantation
SDG 3 - Good Health and Well-being
topic bone fractures
hemodialysis
magnesium
secondary hyperparathyroidism
vascular calcifications
Nephrology
Transplantation
SDG 3 - Good Health and Well-being
description Publisher Copyright: © The Author(s) 2024.
publishDate 2025
dc.date.none.fl_str_mv 2025-01-31T21:15:25Z
2025-01-01
2025-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/178237
url http://hdl.handle.net/10362/178237
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2048-8505
PURE: 108260289
https://doi.org/10.1093/ckj/sfae381
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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