Improvement of Mineral and Bone Disorders After Renal Transplantation

Bibliographic Details
Main Author: Ferreira, Ana Carina
Publication Date: 2022
Other Authors: Mendes, Marco, Silva, Cecília, Cotovio, Patrícia, Aires, Inês, Navarro, David, Caeiro, Fernando, Ramos, Rúben, Salvador, Rute, Correia, Bruna, Cabral, Guadalupe, Nolasco, Fernando, Ferreira, Aníbal
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/162970
Summary: Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.
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spelling Improvement of Mineral and Bone Disorders After Renal TransplantationCopyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.BACKGROUND: Posttransplant mineral and bone diseases are causes of fractures, and their association with cardiovascular events is being studied. METHODS: We analyzed the evolution of biochemical, histological, and imaging parameters pre- and 1 y post-renal transplantation in 69 patients and correlated mineral and bone findings with coronary calcifications. At inclusion and after 12 mo, clinical data and echocardiographic findings were recorded, and laboratory evaluations, radiography of the pelvis and hands, and bone biopsy were performed. Noncontrast cardiac computed tomography was performed during the second evaluation. RESULTS: Serum levels of fibroblast growth factor 23 and sclerostin decreased in all patients, parathyroid hormone levels decreased in 89.8% of patients, bone alkaline phosphatase levels decreased in 68.1% of patients, and alpha-Klotho levels increased in 65.2% of patients. More than half of the patients presented with renal osteodystrophy at both biopsies, but histological findings improved: a significant transition from high to normal or low turnover and no significant differences in volume, mineralization defect, or cortical porosity at the 2 evaluations. Alpha-Klotho, sclerostin, and bone alkaline phosphatase shifts affect bone changes. Neither echocardiographic findings nor vascular calcification scores differed between the 2 points. Both the pretransplant period (dialysis vintage, sclerostin, and low bone volume at baseline) and the maintenance of abnormalities in the posttransplant period (high turnover posttransplant) were the most reliable predictors of the severity of the coronary calcification percentile. CONCLUSIONS: Renal transplantation improved bone and mineral abnormalities. The pretransplant period determines the severity of calcification.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centro de Estudos de Doenças Crónicas (CEDOC)RUNFerreira, Ana CarinaMendes, MarcoSilva, CecíliaCotovio, PatríciaAires, InêsNavarro, DavidCaeiro, FernandoRamos, RúbenSalvador, RuteCorreia, BrunaCabral, GuadalupeNolasco, FernandoFerreira, Aníbal2024-01-31T22:34:42Z2022-05-012022-05-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/162970eng1527-6465PURE: 42454336https://doi.org/10.1097/TP.0000000000004099info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T18:17:57Zoai:run.unl.pt:10362/162970Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:48:20.966093Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Improvement of Mineral and Bone Disorders After Renal Transplantation
title Improvement of Mineral and Bone Disorders After Renal Transplantation
spellingShingle Improvement of Mineral and Bone Disorders After Renal Transplantation
Ferreira, Ana Carina
title_short Improvement of Mineral and Bone Disorders After Renal Transplantation
title_full Improvement of Mineral and Bone Disorders After Renal Transplantation
title_fullStr Improvement of Mineral and Bone Disorders After Renal Transplantation
title_full_unstemmed Improvement of Mineral and Bone Disorders After Renal Transplantation
title_sort Improvement of Mineral and Bone Disorders After Renal Transplantation
author Ferreira, Ana Carina
author_facet Ferreira, Ana Carina
Mendes, Marco
Silva, Cecília
Cotovio, Patrícia
Aires, Inês
Navarro, David
Caeiro, Fernando
Ramos, Rúben
Salvador, Rute
Correia, Bruna
Cabral, Guadalupe
Nolasco, Fernando
Ferreira, Aníbal
author_role author
author2 Mendes, Marco
Silva, Cecília
Cotovio, Patrícia
Aires, Inês
Navarro, David
Caeiro, Fernando
Ramos, Rúben
Salvador, Rute
Correia, Bruna
Cabral, Guadalupe
Nolasco, Fernando
Ferreira, Aníbal
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Centro de Estudos de Doenças Crónicas (CEDOC)
RUN
dc.contributor.author.fl_str_mv Ferreira, Ana Carina
Mendes, Marco
Silva, Cecília
Cotovio, Patrícia
Aires, Inês
Navarro, David
Caeiro, Fernando
Ramos, Rúben
Salvador, Rute
Correia, Bruna
Cabral, Guadalupe
Nolasco, Fernando
Ferreira, Aníbal
description Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.
publishDate 2022
dc.date.none.fl_str_mv 2022-05-01
2022-05-01T00:00:00Z
2024-01-31T22:34:42Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/162970
url http://hdl.handle.net/10362/162970
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1527-6465
PURE: 42454336
https://doi.org/10.1097/TP.0000000000004099
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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