The Role of DsrC in Dissimilatory Sulfite Reduction

Bibliographic Details
Main Author: Preto, André Gonçalves Carvalho
Publication Date: 2015
Format: Master thesis
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/43591
Summary: Studies involving the human gastrointestinal microbiota and its metabolites have revealed the presence of sulfate-reducing bacteria (SRB) within the gut. These microorganisms have been implicated in inflammatory bowel diseases due to the toxic effects of sulfide, produced during dissimilatory sulfate reduction, leading to cell inflammation. The reduction of sulfite to sulfide is carried out by the dissimilatory sulfite reductase, DsrAB, and also involves the DsrC protein, which is a major protein in the cell and contains two conserved redox-active cysteines in a flexible C-terminal arm. The disulfide bond formed between these two conserved cysteines during sulfite reduction is believed to be reduced by several proteins that are related to the catalytic subunits of the heterodisulfide reductases (Hdr) of methanogens, namely HdrB and HdrD.
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spelling The Role of DsrC in Dissimilatory Sulfite ReductionInflammatory Bowel DiseasesSulfate-reducing BacteriaDissimilatory sulfate reductionDsrCBiological SciencesBiochemistry for HealthStudies involving the human gastrointestinal microbiota and its metabolites have revealed the presence of sulfate-reducing bacteria (SRB) within the gut. These microorganisms have been implicated in inflammatory bowel diseases due to the toxic effects of sulfide, produced during dissimilatory sulfate reduction, leading to cell inflammation. The reduction of sulfite to sulfide is carried out by the dissimilatory sulfite reductase, DsrAB, and also involves the DsrC protein, which is a major protein in the cell and contains two conserved redox-active cysteines in a flexible C-terminal arm. The disulfide bond formed between these two conserved cysteines during sulfite reduction is believed to be reduced by several proteins that are related to the catalytic subunits of the heterodisulfide reductases (Hdr) of methanogens, namely HdrB and HdrD.Pereira, Inês CardosoVenceslau, SofiaRUNPreto, André Gonçalves Carvalho2018-12-31T01:30:34Z2015-11-2420152015-11-24T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfapplication/pdfhttp://hdl.handle.net/10362/43591TID:202011933enginfo:eu-repo/semantics/embargoedAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T17:34:24Zoai:run.unl.pt:10362/43591Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:05:34.280217Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv The Role of DsrC in Dissimilatory Sulfite Reduction
title The Role of DsrC in Dissimilatory Sulfite Reduction
spellingShingle The Role of DsrC in Dissimilatory Sulfite Reduction
Preto, André Gonçalves Carvalho
Inflammatory Bowel Diseases
Sulfate-reducing Bacteria
Dissimilatory sulfate reduction
DsrC
Biological Sciences
Biochemistry for Health
title_short The Role of DsrC in Dissimilatory Sulfite Reduction
title_full The Role of DsrC in Dissimilatory Sulfite Reduction
title_fullStr The Role of DsrC in Dissimilatory Sulfite Reduction
title_full_unstemmed The Role of DsrC in Dissimilatory Sulfite Reduction
title_sort The Role of DsrC in Dissimilatory Sulfite Reduction
author Preto, André Gonçalves Carvalho
author_facet Preto, André Gonçalves Carvalho
author_role author
dc.contributor.none.fl_str_mv Pereira, Inês Cardoso
Venceslau, Sofia
RUN
dc.contributor.author.fl_str_mv Preto, André Gonçalves Carvalho
dc.subject.por.fl_str_mv Inflammatory Bowel Diseases
Sulfate-reducing Bacteria
Dissimilatory sulfate reduction
DsrC
Biological Sciences
Biochemistry for Health
topic Inflammatory Bowel Diseases
Sulfate-reducing Bacteria
Dissimilatory sulfate reduction
DsrC
Biological Sciences
Biochemistry for Health
description Studies involving the human gastrointestinal microbiota and its metabolites have revealed the presence of sulfate-reducing bacteria (SRB) within the gut. These microorganisms have been implicated in inflammatory bowel diseases due to the toxic effects of sulfide, produced during dissimilatory sulfate reduction, leading to cell inflammation. The reduction of sulfite to sulfide is carried out by the dissimilatory sulfite reductase, DsrAB, and also involves the DsrC protein, which is a major protein in the cell and contains two conserved redox-active cysteines in a flexible C-terminal arm. The disulfide bond formed between these two conserved cysteines during sulfite reduction is believed to be reduced by several proteins that are related to the catalytic subunits of the heterodisulfide reductases (Hdr) of methanogens, namely HdrB and HdrD.
publishDate 2015
dc.date.none.fl_str_mv 2015-11-24
2015
2015-11-24T00:00:00Z
2018-12-31T01:30:34Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/43591
TID:202011933
url http://hdl.handle.net/10362/43591
identifier_str_mv TID:202011933
dc.language.iso.fl_str_mv eng
language eng
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dc.format.none.fl_str_mv application/pdf
application/pdf
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instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
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instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
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collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
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