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Retinoic acid: a key regulator of lung development

Detalhes bibliográficos
Autor(a) principal: Fernandes-Silva, Hugo
Data de Publicação: 2020
Outros Autores: Araújo-Silva, Henrique, Correia-Pinto, Jorge, Moura, Rute S
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Texto Completo: http://hdl.handle.net/1822/63882
Resumo: Retinoic acid (RA) is a key molecular player in embryogenesis and adult tissue homeostasis. In embryo development, RA plays a crucial role in the formation of different organ systems, namely, the respiratory system. During lung development, there is a spatiotemporal regulation of RA levels that assures the formation of a fully functional organ. RA signaling influences lung specification, branching morphogenesis, and alveolarization by regulating the expression of particular target genes. Moreover, cooperation with other developmental pathways is essential to shape lung organogenesis. This review focuses on the events regulated by retinoic acid during lung developmental phases and pulmonary vascular development; also, it aims to provide a snapshot of RA interplay with other well-known regulators of lung development.
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spelling Retinoic acid: a key regulator of lung developmentvitamin Aretinolrespiratory systemlung specificationbranching morphogenesisalveologenesisScience & TechnologyRetinoic acid (RA) is a key molecular player in embryogenesis and adult tissue homeostasis. In embryo development, RA plays a crucial role in the formation of different organ systems, namely, the respiratory system. During lung development, there is a spatiotemporal regulation of RA levels that assures the formation of a fully functional organ. RA signaling influences lung specification, branching morphogenesis, and alveolarization by regulating the expression of particular target genes. Moreover, cooperation with other developmental pathways is essential to shape lung organogenesis. This review focuses on the events regulated by retinoic acid during lung developmental phases and pulmonary vascular development; also, it aims to provide a snapshot of RA interplay with other well-known regulators of lung development.This work has been funded by FEDER through the Competitiveness Factors Operational Program (COMPETE), by National funds through the Foundation for Science and Technology (FCT) under the scope of the project UID/Multi/50026/2019; and by the project NORTE-01-0145-FEDER-000013, supported by the Northern Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (FEDER). H.F.-S. was supported by a doctoral fellowship (PD/BD/137655/2018) from FCT, as part of the Inter-University Doctoral Programme in Ageing and Chronic Disease (PhDOC). Funding bodies did not play any role in the study design, data collection, and analysis, publication decisions or preparation of the manuscript.Multidisciplinary Digital Publishing InstituteUniversidade do MinhoFernandes-Silva, HugoAraújo-Silva, HenriqueCorreia-Pinto, JorgeMoura, Rute S2020-01-172020-01-17T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/63882engFernandes-Silva, H.; Araújo-Silva, H.; Correia-Pinto, J.; Moura, R.S. Retinoic Acid: A Key Regulator of Lung Development. Biomolecules 2020, 10, 152.2218-273X10.3390/biom1001015231963453https://www.mdpi.com/2218-273X/10/1/152info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-11T07:16:29Zoai:repositorium.sdum.uminho.pt:1822/63882Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T16:21:38.365309Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Retinoic acid: a key regulator of lung development
title Retinoic acid: a key regulator of lung development
spellingShingle Retinoic acid: a key regulator of lung development
Fernandes-Silva, Hugo
vitamin A
retinol
respiratory system
lung specification
branching morphogenesis
alveologenesis
Science & Technology
title_short Retinoic acid: a key regulator of lung development
title_full Retinoic acid: a key regulator of lung development
title_fullStr Retinoic acid: a key regulator of lung development
title_full_unstemmed Retinoic acid: a key regulator of lung development
title_sort Retinoic acid: a key regulator of lung development
author Fernandes-Silva, Hugo
author_facet Fernandes-Silva, Hugo
Araújo-Silva, Henrique
Correia-Pinto, Jorge
Moura, Rute S
author_role author
author2 Araújo-Silva, Henrique
Correia-Pinto, Jorge
Moura, Rute S
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Fernandes-Silva, Hugo
Araújo-Silva, Henrique
Correia-Pinto, Jorge
Moura, Rute S
dc.subject.por.fl_str_mv vitamin A
retinol
respiratory system
lung specification
branching morphogenesis
alveologenesis
Science & Technology
topic vitamin A
retinol
respiratory system
lung specification
branching morphogenesis
alveologenesis
Science & Technology
description Retinoic acid (RA) is a key molecular player in embryogenesis and adult tissue homeostasis. In embryo development, RA plays a crucial role in the formation of different organ systems, namely, the respiratory system. During lung development, there is a spatiotemporal regulation of RA levels that assures the formation of a fully functional organ. RA signaling influences lung specification, branching morphogenesis, and alveolarization by regulating the expression of particular target genes. Moreover, cooperation with other developmental pathways is essential to shape lung organogenesis. This review focuses on the events regulated by retinoic acid during lung developmental phases and pulmonary vascular development; also, it aims to provide a snapshot of RA interplay with other well-known regulators of lung development.
publishDate 2020
dc.date.none.fl_str_mv 2020-01-17
2020-01-17T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/63882
url http://hdl.handle.net/1822/63882
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Fernandes-Silva, H.; Araújo-Silva, H.; Correia-Pinto, J.; Moura, R.S. Retinoic Acid: A Key Regulator of Lung Development. Biomolecules 2020, 10, 152.
2218-273X
10.3390/biom10010152
31963453
https://www.mdpi.com/2218-273X/10/1/152
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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