Characteristic Immune Dynamics in COVID-19 Patients with Cardiac Dysfunction

Bibliographic Details
Main Author: Gonzalez, Filipe André
Publication Date: 2022
Other Authors: Ângelo-Dias, Miguel, Martins, Catarina, Gomes, Rui, Bacariza, Jacobo, Fernandes, Antero, Borrego, Luís Miguel
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/136121
Summary: Funding Information: Type of funding sources: Foundation—015_595935779—Foundation for Science and Technology (FCT), in collaboration with the Agency for Clinical Research and Biomedical Innovation (AICIB) opened special funding, “RESEARCH 4 COVID-19”, to R&D projects and initiatives that respond to the needs of the National Health Service (SNS) as a response to this and future pandemics in a very short time Horizon. Project: “Early recognition of cardiac injury associated with COVID-19 and clinical outcomes”.
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spelling Characteristic Immune Dynamics in COVID-19 Patients with Cardiac DysfunctionCOVID-19diastolic dysfunctionflow cytometryspeckle-tracking echocardiographyMedicine(all)Funding Information: Type of funding sources: Foundation—015_595935779—Foundation for Science and Technology (FCT), in collaboration with the Agency for Clinical Research and Biomedical Innovation (AICIB) opened special funding, “RESEARCH 4 COVID-19”, to R&D projects and initiatives that respond to the needs of the National Health Service (SNS) as a response to this and future pandemics in a very short time Horizon. Project: “Early recognition of cardiac injury associated with COVID-19 and clinical outcomes”.Background: We aimed to explore immune parameters in COVID-19 patients admitted to the intensive care unit (ICU) to identify distinctive features in patients with cardiac injury. Methods: A total of 30 COVID-19 patients >18 years admitted to the ICU were studied on days D1, D3 and D7 after admission. Cardiac function was assessed using speckle-tracking echocardiography (STE). Peripheral blood immunophenotyping, cardiac (pro-BNP; troponin) and inflammatory biomarkers were simultaneously evaluated. Results: Cardiac dysfunction (DYS) was detected by STE in 73% of patients: 40% left ventricle (LV) systolic dysfunction, 60% LV diastolic dysfunction, 37% right ventricle systolic dysfunction. High-sensitivity cardiac troponin (hs-cTn) was detectable in 43.3% of the patients with a median value of 13.00 ng/L. There were no significant differences between DYS and nDYS patients regarding mortality, organ dysfunction, cardiac (including hs-cTn) or inflammatory biomarkers. Patients with DYS showed persistently lower lymphocyte counts (median 896 [661–1837] cells/µL vs. 2141 [924–3306] cells/µL, p = 0.058), activated CD3 (median 85 [66–170] cells/µL vs. 186 [142–259] cells/µL, p = 0.047) and CD4 T cells (median 33 [28–40] cells/µL vs. 63 [48–79] cells/µL, p = 0.005), and higher effector memory T cells (TEM) at baseline (CD4%: 10.9 [6.4–19.2] vs. 5.9 [4.2–12.8], p = 0.025; CD8%: 15.7 [7.9–22.8] vs. 8.1 [7.7–13.7], p = 0.035; CD8 counts: 40 cells/µL [17–61] vs. 10 cells/µL [7–17], p = 0.011) than patients without cardiac dysfunction. Conclusion: Our study suggests an association between the immunological trait and cardiac dysfunction in severe COVID-19 patients.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centro de Estudos de Doenças Crónicas (CEDOC)RUNGonzalez, Filipe AndréÂngelo-Dias, MiguelMartins, CatarinaGomes, RuiBacariza, JacoboFernandes, AnteroBorrego, Luís Miguel2022-04-08T22:36:07Z2022-03-282022-03-28T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/136121eng2077-0383PURE: 43040553https://doi.org/10.3390/jcm11071880info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T18:01:02Zoai:run.unl.pt:10362/136121Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:32:03.356332Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Characteristic Immune Dynamics in COVID-19 Patients with Cardiac Dysfunction
title Characteristic Immune Dynamics in COVID-19 Patients with Cardiac Dysfunction
spellingShingle Characteristic Immune Dynamics in COVID-19 Patients with Cardiac Dysfunction
Gonzalez, Filipe André
COVID-19
diastolic dysfunction
flow cytometry
speckle-tracking echocardiography
Medicine(all)
title_short Characteristic Immune Dynamics in COVID-19 Patients with Cardiac Dysfunction
title_full Characteristic Immune Dynamics in COVID-19 Patients with Cardiac Dysfunction
title_fullStr Characteristic Immune Dynamics in COVID-19 Patients with Cardiac Dysfunction
title_full_unstemmed Characteristic Immune Dynamics in COVID-19 Patients with Cardiac Dysfunction
title_sort Characteristic Immune Dynamics in COVID-19 Patients with Cardiac Dysfunction
author Gonzalez, Filipe André
author_facet Gonzalez, Filipe André
Ângelo-Dias, Miguel
Martins, Catarina
Gomes, Rui
Bacariza, Jacobo
Fernandes, Antero
Borrego, Luís Miguel
author_role author
author2 Ângelo-Dias, Miguel
Martins, Catarina
Gomes, Rui
Bacariza, Jacobo
Fernandes, Antero
Borrego, Luís Miguel
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Centro de Estudos de Doenças Crónicas (CEDOC)
RUN
dc.contributor.author.fl_str_mv Gonzalez, Filipe André
Ângelo-Dias, Miguel
Martins, Catarina
Gomes, Rui
Bacariza, Jacobo
Fernandes, Antero
Borrego, Luís Miguel
dc.subject.por.fl_str_mv COVID-19
diastolic dysfunction
flow cytometry
speckle-tracking echocardiography
Medicine(all)
topic COVID-19
diastolic dysfunction
flow cytometry
speckle-tracking echocardiography
Medicine(all)
description Funding Information: Type of funding sources: Foundation—015_595935779—Foundation for Science and Technology (FCT), in collaboration with the Agency for Clinical Research and Biomedical Innovation (AICIB) opened special funding, “RESEARCH 4 COVID-19”, to R&D projects and initiatives that respond to the needs of the National Health Service (SNS) as a response to this and future pandemics in a very short time Horizon. Project: “Early recognition of cardiac injury associated with COVID-19 and clinical outcomes”.
publishDate 2022
dc.date.none.fl_str_mv 2022-04-08T22:36:07Z
2022-03-28
2022-03-28T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/136121
url http://hdl.handle.net/10362/136121
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2077-0383
PURE: 43040553
https://doi.org/10.3390/jcm11071880
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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