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Properties of collagen/sodium alginate hydrogels for bioprinting of skin models

Bibliographic Details
Main Author: Tian Jiao, Q. L.
Publication Date: 2023
Other Authors: Lian, W., Wang, Y., Li, D., Reis, R. L., Oliveira, Joaquim M.
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: https://hdl.handle.net/1822/79493
Summary: Published: 07 September 2022
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spelling Properties of collagen/sodium alginate hydrogels for bioprinting of skin modelsBioprintingCollagenskin modelsBioinksodium alginate hydrogelSkinWound healingBionicCollagen/sodium alginate hydrogelScience & TechnologyPublished: 07 September 20223D printing technology has great potential for the reconstruction of human skin. However, the reconstructed skin has some differences from natural skin, largely because the hydrogel used does not have the appropriate biological and physical properties to allow healing and regeneration. This study examines the swelling, degradability, microstructure and biological properties of Collagen/Sodium Alginate (Col/SA) hydrogels of differing compositions for the purposes of skin printing. Increasing the content of sodium alginate causes the hydrogel to exhibit stronger mechanical and swelling properties, a faster degradation ratio, smaller pore size, and less favorable biological properties. An optimal 1% collagen hydrogel was used to print bi-layer skin in which fibroblasts and keratinocytes showed improved spreading and proliferation as compared to other developed formulations. The Col/SA hydrogels presented suitable tunability and properties to be used as a bioink for bioprinting of skin aiming at finding applications as 3D models for wound healing research.This research was funded by the National Key R&D Program of China (2018YFE0207900), and People's Liberation Army (BWS17J036, 18-163-13-ZT-003-011-01) and the National Natural Science Foundation of China (51835010 and 51375371), and Xi’an Science and Technology Plan Project (21ZCZZHXJS-QCY6-0012). Shaanxi Science and Technology Project (2022KXJ-147). Thanks to Shi Changquan and Yang Chuncheng of Shaanxi Ketao-AM Technology Co., Ltd. for their technical support for printing equipment.SpringerUniversidade do MinhoTian Jiao, Q. L.Lian, W.Wang, Y.Li, D.Reis, R. L.Oliveira, Joaquim M.20232023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/79493engJiao, T., Lian, Q., Lian, W. et al. Properties of Collagen/Sodium Alginate Hydrogels for Bioprinting of Skin Models. J Bionic Eng 20, 105–118 (2023). https://doi.org/10.1007/s42235-022-00251-82543-214110.1007/s42235-022-00251-8https://link.springer.com/article/10.1007/s42235-022-00251-8info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-11T05:27:31Zoai:repositorium.sdum.uminho.pt:1822/79493Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T15:19:19.768441Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Properties of collagen/sodium alginate hydrogels for bioprinting of skin models
title Properties of collagen/sodium alginate hydrogels for bioprinting of skin models
spellingShingle Properties of collagen/sodium alginate hydrogels for bioprinting of skin models
Tian Jiao, Q. L.
Bioprinting
Collagen
skin models
Bioink
sodium alginate hydrogel
Skin
Wound healing
Bionic
Collagen/sodium alginate hydrogel
Science & Technology
title_short Properties of collagen/sodium alginate hydrogels for bioprinting of skin models
title_full Properties of collagen/sodium alginate hydrogels for bioprinting of skin models
title_fullStr Properties of collagen/sodium alginate hydrogels for bioprinting of skin models
title_full_unstemmed Properties of collagen/sodium alginate hydrogels for bioprinting of skin models
title_sort Properties of collagen/sodium alginate hydrogels for bioprinting of skin models
author Tian Jiao, Q. L.
author_facet Tian Jiao, Q. L.
Lian, W.
Wang, Y.
Li, D.
Reis, R. L.
Oliveira, Joaquim M.
author_role author
author2 Lian, W.
Wang, Y.
Li, D.
Reis, R. L.
Oliveira, Joaquim M.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Tian Jiao, Q. L.
Lian, W.
Wang, Y.
Li, D.
Reis, R. L.
Oliveira, Joaquim M.
dc.subject.por.fl_str_mv Bioprinting
Collagen
skin models
Bioink
sodium alginate hydrogel
Skin
Wound healing
Bionic
Collagen/sodium alginate hydrogel
Science & Technology
topic Bioprinting
Collagen
skin models
Bioink
sodium alginate hydrogel
Skin
Wound healing
Bionic
Collagen/sodium alginate hydrogel
Science & Technology
description Published: 07 September 2022
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/79493
url https://hdl.handle.net/1822/79493
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Jiao, T., Lian, Q., Lian, W. et al. Properties of Collagen/Sodium Alginate Hydrogels for Bioprinting of Skin Models. J Bionic Eng 20, 105–118 (2023). https://doi.org/10.1007/s42235-022-00251-8
2543-2141
10.1007/s42235-022-00251-8
https://link.springer.com/article/10.1007/s42235-022-00251-8
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833595240939782144

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