Retinoic acid signaling in spermatogenesis and male (in)fertility

Detalhes bibliográficos
Autor(a) principal: Santos, Dario
Data de Publicação: 2019
Outros Autores: Payan-Carreira, Rita
Idioma: por
Título da fonte: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Texto Completo: http://hdl.handle.net/10174/26186
https://doi.org/10.1201/9780429244216
Resumo: Spermatogenesis is a very complex, highly organised and timely regulated event, in which spermatozoa originated from undifferentiated spermatogonia that are recruited into the differentiation pathway and meiosis. The spermatogonia entrance into the differentiation pathway is temporally controlled, which in mammals occurs in a progressive non-uniform manner along the tubule at space intervals, allowing spermatozoa production in a continuum. Vitamin A has been implicated for long in the spermatogenesis homeostasis and fertility. In the past two decades, new insights evidenced that retinoic acid drives the asynchronous initiation of spermatogonial differentiation, promotes the transition from preleptetone to leptotene spermatocyte and therefore the onset of male meiosis, and mediates postmeiotic transitions. Evidences showed that RA plays a broad and encompassing role in regulating and coordinating spermatogenesis. This chapter intends to provide an overview of the role of retinoic acid signalling in spermatogenesis.
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spelling Retinoic acid signaling in spermatogenesis and male (in)fertilitySpermatogenic cycleRetinoidsVitamin ASpermatogenesisFertilitySpermatogenesis is a very complex, highly organised and timely regulated event, in which spermatozoa originated from undifferentiated spermatogonia that are recruited into the differentiation pathway and meiosis. The spermatogonia entrance into the differentiation pathway is temporally controlled, which in mammals occurs in a progressive non-uniform manner along the tubule at space intervals, allowing spermatozoa production in a continuum. Vitamin A has been implicated for long in the spermatogenesis homeostasis and fertility. In the past two decades, new insights evidenced that retinoic acid drives the asynchronous initiation of spermatogonial differentiation, promotes the transition from preleptetone to leptotene spermatocyte and therefore the onset of male meiosis, and mediates postmeiotic transitions. Evidences showed that RA plays a broad and encompassing role in regulating and coordinating spermatogenesis. This chapter intends to provide an overview of the role of retinoic acid signalling in spermatogenesis.CRC Press2019-12-20T17:24:29Z2019-12-202019-11-01T00:00:00Zbook partinfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10174/26186http://hdl.handle.net/10174/26186https://doi.org/10.1201/9780429244216porD. Santos, R. Payan-Carreira (2019). Retinoic acid signaling in spermatogenesis and male (in)fertility. In: Molecular Signaling in Spermatogenesis and Male Infertility. Singh R. (Ed.). Chapt. 7. (63-76). Boca Raton, CRC Press [Taylor & Francis group] ISBN: 9780429244216https://www.taylorfrancis.com/books/e/9780429244216partilha com coleção do DVM & partilha com repositório da UTADndrtpayan@uevora.pt206Santos, DarioPayan-Carreira, Ritainfo:eu-repo/semantics/embargoedAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-01-03T19:20:41Zoai:dspace.uevora.pt:10174/26186Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T12:19:52.857914Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Retinoic acid signaling in spermatogenesis and male (in)fertility
title Retinoic acid signaling in spermatogenesis and male (in)fertility
spellingShingle Retinoic acid signaling in spermatogenesis and male (in)fertility
Santos, Dario
Spermatogenic cycle
Retinoids
Vitamin A
Spermatogenesis
Fertility
title_short Retinoic acid signaling in spermatogenesis and male (in)fertility
title_full Retinoic acid signaling in spermatogenesis and male (in)fertility
title_fullStr Retinoic acid signaling in spermatogenesis and male (in)fertility
title_full_unstemmed Retinoic acid signaling in spermatogenesis and male (in)fertility
title_sort Retinoic acid signaling in spermatogenesis and male (in)fertility
author Santos, Dario
author_facet Santos, Dario
Payan-Carreira, Rita
author_role author
author2 Payan-Carreira, Rita
author2_role author
dc.contributor.author.fl_str_mv Santos, Dario
Payan-Carreira, Rita
dc.subject.por.fl_str_mv Spermatogenic cycle
Retinoids
Vitamin A
Spermatogenesis
Fertility
topic Spermatogenic cycle
Retinoids
Vitamin A
Spermatogenesis
Fertility
description Spermatogenesis is a very complex, highly organised and timely regulated event, in which spermatozoa originated from undifferentiated spermatogonia that are recruited into the differentiation pathway and meiosis. The spermatogonia entrance into the differentiation pathway is temporally controlled, which in mammals occurs in a progressive non-uniform manner along the tubule at space intervals, allowing spermatozoa production in a continuum. Vitamin A has been implicated for long in the spermatogenesis homeostasis and fertility. In the past two decades, new insights evidenced that retinoic acid drives the asynchronous initiation of spermatogonial differentiation, promotes the transition from preleptetone to leptotene spermatocyte and therefore the onset of male meiosis, and mediates postmeiotic transitions. Evidences showed that RA plays a broad and encompassing role in regulating and coordinating spermatogenesis. This chapter intends to provide an overview of the role of retinoic acid signalling in spermatogenesis.
publishDate 2019
dc.date.none.fl_str_mv 2019-12-20T17:24:29Z
2019-12-20
2019-11-01T00:00:00Z
dc.type.driver.fl_str_mv book part
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10174/26186
http://hdl.handle.net/10174/26186
https://doi.org/10.1201/9780429244216
url http://hdl.handle.net/10174/26186
https://doi.org/10.1201/9780429244216
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv D. Santos, R. Payan-Carreira (2019). Retinoic acid signaling in spermatogenesis and male (in)fertility. In: Molecular Signaling in Spermatogenesis and Male Infertility. Singh R. (Ed.). Chapt. 7. (63-76). Boca Raton, CRC Press [Taylor & Francis group] ISBN: 9780429244216
https://www.taylorfrancis.com/books/e/9780429244216
partilha com coleção do DVM & partilha com repositório da UTAD
nd
rtpayan@uevora.pt
206
dc.rights.driver.fl_str_mv info:eu-repo/semantics/embargoedAccess
eu_rights_str_mv embargoedAccess
dc.publisher.none.fl_str_mv CRC Press
publisher.none.fl_str_mv CRC Press
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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