Chiral analysis of pesticides and drugs of environmental concern: biodegradation and enantiomeric fraction

Bibliographic Details
Main Author: Maia, Alexandra S.
Publication Date: 2017
Other Authors: Ribeiro, Ana R., Castro, Paula M. L., Tiritan, Maria Elizabeth
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10400.14/23730
Summary: The importance of stereochemistry for medicinal chemistry and pharmacology is well recognized and the dissimilar behavior of enantiomers is fully documented. Regarding the environment, the significance is equivalent since enantiomers of chiral organic pollutants can also differ in biodegradation processes and fate, as well as in ecotoxicity. This review comprises designed biodegradation studies of several chiral drugs and pesticides followed by enantioselective analytical methodologies to accurately measure the enantiomeric fraction (EF). The enantioselective monitoring of microcosms and laboratory-scale experiments with different environmental matrices is herein reported. Thus, this review focuses on the importance of evaluating the EF variation during biodegradation studies of chiral pharmaceuticals, drugs of abuse, and agrochemicals and has implications for the understanding of the environmental fate of chiral pollutants.
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spelling Chiral analysis of pesticides and drugs of environmental concern: biodegradation and enantiomeric fractionEnantiomeric fraction (EF)EnantioselectivityChiral analysisBiodegradationPesticidesPharmaceuticalsThe importance of stereochemistry for medicinal chemistry and pharmacology is well recognized and the dissimilar behavior of enantiomers is fully documented. Regarding the environment, the significance is equivalent since enantiomers of chiral organic pollutants can also differ in biodegradation processes and fate, as well as in ecotoxicity. This review comprises designed biodegradation studies of several chiral drugs and pesticides followed by enantioselective analytical methodologies to accurately measure the enantiomeric fraction (EF). The enantioselective monitoring of microcosms and laboratory-scale experiments with different environmental matrices is herein reported. Thus, this review focuses on the importance of evaluating the EF variation during biodegradation studies of chiral pharmaceuticals, drugs of abuse, and agrochemicals and has implications for the understanding of the environmental fate of chiral pollutants.MDPIVeritatiMaia, Alexandra S.Ribeiro, Ana R.Castro, Paula M. L.Tiritan, Maria Elizabeth2017-12-18T19:45:35Z20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.14/23730eng2073-899410.3390/sym9090196info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-13T10:44:26Zoai:repositorio.ucp.pt:10400.14/23730Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T01:37:25.065562Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Chiral analysis of pesticides and drugs of environmental concern: biodegradation and enantiomeric fraction
title Chiral analysis of pesticides and drugs of environmental concern: biodegradation and enantiomeric fraction
spellingShingle Chiral analysis of pesticides and drugs of environmental concern: biodegradation and enantiomeric fraction
Maia, Alexandra S.
Enantiomeric fraction (EF)
Enantioselectivity
Chiral analysis
Biodegradation
Pesticides
Pharmaceuticals
title_short Chiral analysis of pesticides and drugs of environmental concern: biodegradation and enantiomeric fraction
title_full Chiral analysis of pesticides and drugs of environmental concern: biodegradation and enantiomeric fraction
title_fullStr Chiral analysis of pesticides and drugs of environmental concern: biodegradation and enantiomeric fraction
title_full_unstemmed Chiral analysis of pesticides and drugs of environmental concern: biodegradation and enantiomeric fraction
title_sort Chiral analysis of pesticides and drugs of environmental concern: biodegradation and enantiomeric fraction
author Maia, Alexandra S.
author_facet Maia, Alexandra S.
Ribeiro, Ana R.
Castro, Paula M. L.
Tiritan, Maria Elizabeth
author_role author
author2 Ribeiro, Ana R.
Castro, Paula M. L.
Tiritan, Maria Elizabeth
author2_role author
author
author
dc.contributor.none.fl_str_mv Veritati
dc.contributor.author.fl_str_mv Maia, Alexandra S.
Ribeiro, Ana R.
Castro, Paula M. L.
Tiritan, Maria Elizabeth
dc.subject.por.fl_str_mv Enantiomeric fraction (EF)
Enantioselectivity
Chiral analysis
Biodegradation
Pesticides
Pharmaceuticals
topic Enantiomeric fraction (EF)
Enantioselectivity
Chiral analysis
Biodegradation
Pesticides
Pharmaceuticals
description The importance of stereochemistry for medicinal chemistry and pharmacology is well recognized and the dissimilar behavior of enantiomers is fully documented. Regarding the environment, the significance is equivalent since enantiomers of chiral organic pollutants can also differ in biodegradation processes and fate, as well as in ecotoxicity. This review comprises designed biodegradation studies of several chiral drugs and pesticides followed by enantioselective analytical methodologies to accurately measure the enantiomeric fraction (EF). The enantioselective monitoring of microcosms and laboratory-scale experiments with different environmental matrices is herein reported. Thus, this review focuses on the importance of evaluating the EF variation during biodegradation studies of chiral pharmaceuticals, drugs of abuse, and agrochemicals and has implications for the understanding of the environmental fate of chiral pollutants.
publishDate 2017
dc.date.none.fl_str_mv 2017-12-18T19:45:35Z
2017
2017-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.14/23730
url http://hdl.handle.net/10400.14/23730
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2073-8994
10.3390/sym9090196
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
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reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
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