Plasmodium falciparum K13 expression associated with parasite clearance during artemisinin-based combination therapy

Bibliographic Details
Main Author: Silva, M.
Publication Date: 2019
Other Authors: Ferreira, P. E., Otienoburu, S. D., Calçada, Carla Sofia Martins, Ngasala, B., Björkman, A., Mårtensson, A., Gil, J. P., Veiga, Maria Isabel Mendes
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: https://hdl.handle.net/1822/62313
Summary: Delayed parasite clearance and, consequently, reduced efficacy of artemisinin-based combination therapies have been linked with Plasmodium falciparum K13 gene SNPs in Southeast Asia. In Africa, significantly prolonged clearance has not yet been observed and the presently restricted variation in parasite clearance cannot be explained by K13 polymorphisms.
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spelling Plasmodium falciparum K13 expression associated with parasite clearance during artemisinin-based combination therapyCiências Médicas::Medicina BásicaScience & TechnologyDelayed parasite clearance and, consequently, reduced efficacy of artemisinin-based combination therapies have been linked with Plasmodium falciparum K13 gene SNPs in Southeast Asia. In Africa, significantly prolonged clearance has not yet been observed and the presently restricted variation in parasite clearance cannot be explained by K13 polymorphisms.Swedish Research Council (VR-2014-3134); the Swedish International Development Cooperation Agency(SWE-200-165); the Northern Portugal Regional Operational Programme(NORTE 2020), under the Portugal 2020 Partnership Agreement, throughthe European Regional Development Fund (NORTE-01-0145-FEDER-000013); and the Fundac ̧~ao para a Cieˆ ncia e Tecnologia (FCT) (SFRH/BD/129769/2017 to M. S., IF/00143/2015 to P. E. F., PD/BD/127826/2016 toC. C. and SFRH/BPD/76614/2011 to M. I. V.Oxford University PressUniversidade do MinhoSilva, M.Ferreira, P. E.Otienoburu, S. D.Calçada, Carla Sofia MartinsNgasala, B.Björkman, A.Mårtensson, A.Gil, J. P.Veiga, Maria Isabel Mendes20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/62313engSilva, M., Ferreira, P. E., Otienoburu, S. D., Calçada, C., et. al. (2019). Plasmodium falciparum K13 expression associated with parasite clearance during artemisinin-based combination therapy. Journal of Antimicrobial Chemotherapy, 74(7), 1890-18930305-74531460-209110.1093/jac/dkz09830869127https://academic.oup.com/jac/article-abstract/74/7/1890/5380571info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-11T05:23:50Zoai:repositorium.sdum.uminho.pt:1822/62313Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T15:17:10.233344Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Plasmodium falciparum K13 expression associated with parasite clearance during artemisinin-based combination therapy
title Plasmodium falciparum K13 expression associated with parasite clearance during artemisinin-based combination therapy
spellingShingle Plasmodium falciparum K13 expression associated with parasite clearance during artemisinin-based combination therapy
Silva, M.
Ciências Médicas::Medicina Básica
Science & Technology
title_short Plasmodium falciparum K13 expression associated with parasite clearance during artemisinin-based combination therapy
title_full Plasmodium falciparum K13 expression associated with parasite clearance during artemisinin-based combination therapy
title_fullStr Plasmodium falciparum K13 expression associated with parasite clearance during artemisinin-based combination therapy
title_full_unstemmed Plasmodium falciparum K13 expression associated with parasite clearance during artemisinin-based combination therapy
title_sort Plasmodium falciparum K13 expression associated with parasite clearance during artemisinin-based combination therapy
author Silva, M.
author_facet Silva, M.
Ferreira, P. E.
Otienoburu, S. D.
Calçada, Carla Sofia Martins
Ngasala, B.
Björkman, A.
Mårtensson, A.
Gil, J. P.
Veiga, Maria Isabel Mendes
author_role author
author2 Ferreira, P. E.
Otienoburu, S. D.
Calçada, Carla Sofia Martins
Ngasala, B.
Björkman, A.
Mårtensson, A.
Gil, J. P.
Veiga, Maria Isabel Mendes
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Silva, M.
Ferreira, P. E.
Otienoburu, S. D.
Calçada, Carla Sofia Martins
Ngasala, B.
Björkman, A.
Mårtensson, A.
Gil, J. P.
Veiga, Maria Isabel Mendes
dc.subject.por.fl_str_mv Ciências Médicas::Medicina Básica
Science & Technology
topic Ciências Médicas::Medicina Básica
Science & Technology
description Delayed parasite clearance and, consequently, reduced efficacy of artemisinin-based combination therapies have been linked with Plasmodium falciparum K13 gene SNPs in Southeast Asia. In Africa, significantly prolonged clearance has not yet been observed and the presently restricted variation in parasite clearance cannot be explained by K13 polymorphisms.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/62313
url https://hdl.handle.net/1822/62313
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Silva, M., Ferreira, P. E., Otienoburu, S. D., Calçada, C., et. al. (2019). Plasmodium falciparum K13 expression associated with parasite clearance during artemisinin-based combination therapy. Journal of Antimicrobial Chemotherapy, 74(7), 1890-1893
0305-7453
1460-2091
10.1093/jac/dkz098
30869127
https://academic.oup.com/jac/article-abstract/74/7/1890/5380571
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833595220501987328

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