Advances in understanding molecular regulation of innate immune memory

Bibliographic Details
Main Author: Domínguez-Andrés, Jorge
Publication Date: 2020
Other Authors: Fanucchi, Stephanie, Joosten, Leo A.B., Mhlanga, Musa, Netea, Mihai G.
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10451/49906
Summary: © 2020 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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spelling Advances in understanding molecular regulation of innate immune memoryEpigeneticsInnate memoryMacrophagesMetabolismMonocytesStem cellsTADsTrained immunitylncRNA© 2020 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).The epigenetic and functional reprogramming of immune genes during induction of trained immunity is accompanied by the metabolic rewiring of cellular state. This memory is induced in the hematopoietic niche and propagated to daughter cells, generating epigenetically and metabolically reprogrammed innate immune cells that are greatly enhanced in their capacity to resolve inflammation. In particular, these cells show accumulation of H3K4me3 and H3K27Ac epigenetic marks on multiple immune gene promoters and associated enhancers. However, the mechanism governing how these epigenetic marks accumulate at discrete immune gene loci has been poorly understood, until now. Here, we discuss some recent advances in the regulation of trained immunity, with a particular focus on the mechanistic role of a novel class of long non-coding RNAs in the establishment of epigenetic marks on trained immune gene promoters.M.G.N. was supported by a Spinoza Grant of the Netherlands Organization for Scientific Research. L.A.B.J. was supported by a Competitiveness Operational Program grant of the Romanian Ministry of European Funds (HINT, ID P_37_762; MySMIS 103587). M.M.M. research is supported by a Department of Science and Technology Centre of Competence Grant, an SA Medical Research Council SHIP grant, and a CSIR Parliamentary Grant, all to M.M.M, and M.M.M. is a Chan Zuckerberg Investigator of the Chan Zuckerberg Initiative.ElsevierRepositório da Universidade de LisboaDomínguez-Andrés, JorgeFanucchi, StephanieJoosten, Leo A.B.Mhlanga, MusaNetea, Mihai G.2021-10-15T13:40:18Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/49906engCurr Opin Cell Biol. 2020 Apr;63:68-750955-067410.1016/j.ceb.2019.12.0061879-0410info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-17T14:37:54Zoai:repositorio.ulisboa.pt:10451/49906Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T03:18:20.441098Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Advances in understanding molecular regulation of innate immune memory
title Advances in understanding molecular regulation of innate immune memory
spellingShingle Advances in understanding molecular regulation of innate immune memory
Domínguez-Andrés, Jorge
Epigenetics
Innate memory
Macrophages
Metabolism
Monocytes
Stem cells
TADs
Trained immunity
lncRNA
title_short Advances in understanding molecular regulation of innate immune memory
title_full Advances in understanding molecular regulation of innate immune memory
title_fullStr Advances in understanding molecular regulation of innate immune memory
title_full_unstemmed Advances in understanding molecular regulation of innate immune memory
title_sort Advances in understanding molecular regulation of innate immune memory
author Domínguez-Andrés, Jorge
author_facet Domínguez-Andrés, Jorge
Fanucchi, Stephanie
Joosten, Leo A.B.
Mhlanga, Musa
Netea, Mihai G.
author_role author
author2 Fanucchi, Stephanie
Joosten, Leo A.B.
Mhlanga, Musa
Netea, Mihai G.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Domínguez-Andrés, Jorge
Fanucchi, Stephanie
Joosten, Leo A.B.
Mhlanga, Musa
Netea, Mihai G.
dc.subject.por.fl_str_mv Epigenetics
Innate memory
Macrophages
Metabolism
Monocytes
Stem cells
TADs
Trained immunity
lncRNA
topic Epigenetics
Innate memory
Macrophages
Metabolism
Monocytes
Stem cells
TADs
Trained immunity
lncRNA
description © 2020 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01T00:00:00Z
2021-10-15T13:40:18Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/49906
url http://hdl.handle.net/10451/49906
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Curr Opin Cell Biol. 2020 Apr;63:68-75
0955-0674
10.1016/j.ceb.2019.12.006
1879-0410
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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