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Burden of liver cirrhosis in Portugal between 2010 and 2017

Bibliographic Details
Main Author: Silva, João Manuel
Publication Date: 2021
Other Authors: Silva, Mário Jorge, Calinas, Filipe, Nogueira, Paulo Jorge
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10451/54026
Summary: © 2020 Sociedade Portuguesa de Gastrenterologia Published by S. Karger AG, Basel. This article is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY- NC-ND) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes as well as any distribution of modified material requires written permission.
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network_name_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
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spelling Burden of liver cirrhosis in Portugal between 2010 and 2017Alcoholic liver diseaseBurdenCirrhosisHepatitis B virusHepatitis C virus© 2020 Sociedade Portuguesa de Gastrenterologia Published by S. Karger AG, Basel. This article is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY- NC-ND) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes as well as any distribution of modified material requires written permission.Introduction: Liver cirrhosis is a prevalent disease in Portugal. Recent changes in alcohol consumption, as well as the wide use of direct-acting antivirals for hepatitis C since 2015, may be contributing to changes in the national burden of liver cirrhosis in the last few years. Objectives: We aim to characterize the burden of cirrhosis in Portugal between 2010 and 2017. Patients and methods: We analyzed all hospital admission episodes due to cirrhosis in Portugal Mainland between 2010 and 2017, registered in the national Diagnosis-Related Group database, according to etiology of cirrhosis. We also analyzed data on mortality and potential years of life lost from liver cirrhosis and chronic liver disease, retrieved from Statistics Portugal (National Institute for Statistics). Results: Between 2010 and 2017, a total of 51,438 admissions for liver cirrhosis occurred in Portugal. The annual number of admissions decreased (p = 0.044) during the analyzed period. The most frequent cause of cirrhosis was alcoholic liver disease, present in 78.9% of all admissions (n = 40,595), followed by chronic hepatitis C virus infection, present in 11.3% (n = 5,823). A male predominance was identified in the admissions for every analyzed cause of cirrhosis. Annual admissions for alcoholic cirrhosis remained stable (p = 0.075) during the 8-year period. The same stable tendency was observed in the number of admissions for cirrhosis caused by hepatitis C virus (p = 0.861) and alcohol plus hepatitis C virus infection (p = 0.082), although these admissions for hepatitis C-related cirrhosis increased until 2014-2015 and steadily decreased thereafter. Annual deaths due to liver cirrhosis and chronic liver disease decreased from 1,357 in 2010 to 1,038 in 2017 (p = 0.002). The number of potential years of life lost decreased as well in the period (p = 0.001). Conclusion: The burden of cirrhosis, evaluated by hospital admissions, mortality, and potential years of life lost, decreased in Portugal between 2010 and 2017.This work was produced with the support of INCD funded by FCT and FEDER under the project 01/SAICT/2016 No. 022153KargerRepositório da Universidade de LisboaSilva, João ManuelSilva, Mário JorgeCalinas, FilipeNogueira, Paulo Jorge2022-08-02T16:17:21Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/54026engGE Port J Gastroenterol. 2021 Apr;28(3):153-1612341-454510.1159/0005107292387-1954info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-17T14:47:19Zoai:repositorio.ulisboa.pt:10451/54026Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T03:24:53.495777Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Burden of liver cirrhosis in Portugal between 2010 and 2017
title Burden of liver cirrhosis in Portugal between 2010 and 2017
spellingShingle Burden of liver cirrhosis in Portugal between 2010 and 2017
Silva, João Manuel
Alcoholic liver disease
Burden
Cirrhosis
Hepatitis B virus
Hepatitis C virus
title_short Burden of liver cirrhosis in Portugal between 2010 and 2017
title_full Burden of liver cirrhosis in Portugal between 2010 and 2017
title_fullStr Burden of liver cirrhosis in Portugal between 2010 and 2017
title_full_unstemmed Burden of liver cirrhosis in Portugal between 2010 and 2017
title_sort Burden of liver cirrhosis in Portugal between 2010 and 2017
author Silva, João Manuel
author_facet Silva, João Manuel
Silva, Mário Jorge
Calinas, Filipe
Nogueira, Paulo Jorge
author_role author
author2 Silva, Mário Jorge
Calinas, Filipe
Nogueira, Paulo Jorge
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Silva, João Manuel
Silva, Mário Jorge
Calinas, Filipe
Nogueira, Paulo Jorge
dc.subject.por.fl_str_mv Alcoholic liver disease
Burden
Cirrhosis
Hepatitis B virus
Hepatitis C virus
topic Alcoholic liver disease
Burden
Cirrhosis
Hepatitis B virus
Hepatitis C virus
description © 2020 Sociedade Portuguesa de Gastrenterologia Published by S. Karger AG, Basel. This article is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY- NC-ND) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes as well as any distribution of modified material requires written permission.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-01-01T00:00:00Z
2022-08-02T16:17:21Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/54026
url http://hdl.handle.net/10451/54026
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv GE Port J Gastroenterol. 2021 Apr;28(3):153-161
2341-4545
10.1159/000510729
2387-1954
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Karger
publisher.none.fl_str_mv Karger
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833601690089029632

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