Change in different classes of chronic back pain suspicious of axial spondyloarthritis
| Main Author: | |
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| Publication Date: | 2024 |
| Other Authors: | , , , , , , , , , , , , |
| Format: | Article |
| Language: | eng |
| Source: | Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
| Download full: | http://hdl.handle.net/10362/172822 |
Summary: | © Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. |
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Change in different classes of chronic back pain suspicious of axial spondyloarthritisa latent transition analysis of the SPACE cohortHumansMaleFemaleBack Pain/etiologyAdultChronic Pain/etiologyAxial Spondyloarthritis/diagnosisMiddle AgedLatent Class AnalysisCohort StudiesDisease ProgressionSpondylarthritis/diagnosis© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.OBJECTIVES: To follow up four previously identified classes 'pure axial spondyloarthritis' (axSpA) ('axial'), 'axSpA with peripheral signs' ('inflammatory back pain+peripheral'), 'axSpA at risk' and 'no spondyloarthritis' ('no SpA'). They reflect the expert-opinion-free construct or 'Gestalt' of chronic back pain suspicious of axSpA. The aim was to assess participants' transitions between these classes over time. METHODS: Participants with chronic back pain of ≤2 years duration, suspicious of axSpA from the SPondyloArthritis Caught Early cohort were analysed. Latent class (LCA) and latent transition analysis (LTA) using clinical, laboratory and imaging data at baseline and 2 years were calculated. Conditional and marginal probabilities were obtained, reflecting the probability of a spondyloarthritis feature in a class and the probability of the participant's class membership, respectively. Transitional probabilities were extracted revealing potential switches across classes. The analyses were performed in all participants using imputations for missing data and in participants with full data at baseline and 2 years. RESULTS: Baseline and 2 years LCA models were constructed for 702 participants, resulting in the same four-class model as previously described. LTA revealed only a 3% transition from the 'no SpA' to the 'at-risk' class from baseline to 2 years with all other participants remaining in their initially assigned class. Sensitivity analysis on 384 participants with complete data at both baseline and 2 years showed similar results, underlining the model's robustness. CONCLUSIONS: Transitions between the four classes over 2 years were basically inexistent, highlighting the unlikelihood of developing new class-defining features of axSpA after an initial clinical workup.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNBosch, PhilippSepriano, AlexandreMarques, Mary-Lucyvan der Heijde, DésiréeLandewé, Robertvan Lunteren, Mirandade Bruin, Liesede Hooge, ManoukBastiaenen, CarolineExarchou, SofiaRamonda, RobertaFagerli, Karen Mindevan Gaalen, Floris ARamiro, Sofia2024-10-01T22:28:38Z2024-09-302024-09-30T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/172822eng2044-6055PURE: 100415417https://doi.org/10.1136/rmdopen-2024-004584info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-05-26T01:41:35Zoai:run.unl.pt:10362/172822Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T18:55:24.004821Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse |
| dc.title.none.fl_str_mv |
Change in different classes of chronic back pain suspicious of axial spondyloarthritis a latent transition analysis of the SPACE cohort |
| title |
Change in different classes of chronic back pain suspicious of axial spondyloarthritis |
| spellingShingle |
Change in different classes of chronic back pain suspicious of axial spondyloarthritis Bosch, Philipp Humans Male Female Back Pain/etiology Adult Chronic Pain/etiology Axial Spondyloarthritis/diagnosis Middle Aged Latent Class Analysis Cohort Studies Disease Progression Spondylarthritis/diagnosis |
| title_short |
Change in different classes of chronic back pain suspicious of axial spondyloarthritis |
| title_full |
Change in different classes of chronic back pain suspicious of axial spondyloarthritis |
| title_fullStr |
Change in different classes of chronic back pain suspicious of axial spondyloarthritis |
| title_full_unstemmed |
Change in different classes of chronic back pain suspicious of axial spondyloarthritis |
| title_sort |
Change in different classes of chronic back pain suspicious of axial spondyloarthritis |
| author |
Bosch, Philipp |
| author_facet |
Bosch, Philipp Sepriano, Alexandre Marques, Mary-Lucy van der Heijde, Désirée Landewé, Robert van Lunteren, Miranda de Bruin, Liese de Hooge, Manouk Bastiaenen, Caroline Exarchou, Sofia Ramonda, Roberta Fagerli, Karen Minde van Gaalen, Floris A Ramiro, Sofia |
| author_role |
author |
| author2 |
Sepriano, Alexandre Marques, Mary-Lucy van der Heijde, Désirée Landewé, Robert van Lunteren, Miranda de Bruin, Liese de Hooge, Manouk Bastiaenen, Caroline Exarchou, Sofia Ramonda, Roberta Fagerli, Karen Minde van Gaalen, Floris A Ramiro, Sofia |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
| dc.contributor.author.fl_str_mv |
Bosch, Philipp Sepriano, Alexandre Marques, Mary-Lucy van der Heijde, Désirée Landewé, Robert van Lunteren, Miranda de Bruin, Liese de Hooge, Manouk Bastiaenen, Caroline Exarchou, Sofia Ramonda, Roberta Fagerli, Karen Minde van Gaalen, Floris A Ramiro, Sofia |
| dc.subject.por.fl_str_mv |
Humans Male Female Back Pain/etiology Adult Chronic Pain/etiology Axial Spondyloarthritis/diagnosis Middle Aged Latent Class Analysis Cohort Studies Disease Progression Spondylarthritis/diagnosis |
| topic |
Humans Male Female Back Pain/etiology Adult Chronic Pain/etiology Axial Spondyloarthritis/diagnosis Middle Aged Latent Class Analysis Cohort Studies Disease Progression Spondylarthritis/diagnosis |
| description |
© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2024-10-01T22:28:38Z 2024-09-30 2024-09-30T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10362/172822 |
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http://hdl.handle.net/10362/172822 |
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eng |
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eng |
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2044-6055 PURE: 100415417 https://doi.org/10.1136/rmdopen-2024-004584 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia instacron:RCAAP |
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Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
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