Pancreatic Cancer Biomarkers: Oncogenic Mutations, Tissue and Liquid Biopsies, and Radiomics-A Review

• Main Author: Amaral, Maria João
• Publication Date: 2023
• Other Authors: Oliveira, Rui C., Donato, Paulo, Tralhão, José Guilherme
• Format: Article
• Language: eng
• Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
• Download full: https://hdl.handle.net/10316/112403; https://doi.org/10.1007/s10620-023-07904-6
• topic: Pancreatic cancer; Biomarkers; Oncogenic mutations; Liquid biopsies; Humans; Liquid Biopsy; Mutation; Biomarkers, Tumor; Pancreatic Neoplasms

Pancreatic cancer is one of the most fatal malignancies, as approximately 80% of patients are at advanced stages by the time of diagnosis. The main reason for the poor overall survival is late diagnosis that is partially due to the lack of tools for early-stage detection. In addition, there are several challenges in evaluating response to treatment and predicting prognosis. In this article, we do a review of the most common pancreatic cancer biomarkers with emphasis in new and promising approaches. Liquid biopsies seem to have important clinical applications in early detection, screening, prognosis, and longitudinal monitoring of on-treatment patients. Together with biomarkers in imaging, can represent valuable alternative non-invasive tools in order to achieve a more effective management of pancreatic cancer patients.