Immunonephelometry in cyclosporin therapy

Detalhes bibliográficos
Autor(a) principal: Pereira-Neves, L.
Data de Publicação: 1990
Outros Autores: Ribeiro da Silva, J., Prata, L., Santos Rosa, M., Mota-Pinto, A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Texto Completo: https://hdl.handle.net/10316/25476
Resumo: Cyclosporin is the most effective drug in human allogenic graf survival. Hypertrichosis, gingival hypertrophy, hypertension, hepatotoxicity have been observed but nephrotocicity seems to be the main problem. Cyclosporine activity seems to be related with peripherical lymphocytes, intraocular levels in systemic administration are not effective, and topical treatment appears to be only useful in corneal disease. Cyclosporine blood levels are important to evaluate intestinal absortion, as well as nephrotoxicity is related with blood levels. Aqueous protein levels are related with inflammatory events in uveitis, and can be easily measured in diary clinic by computorized nephelometry; albumin can be a good reference of blood aqueous barrier “in vivo” with alpha antitripsin directly reflecting inflammatory activity. Evaluation of cyclosporin therapy can be done with only one aqueous tap of 50-100ul and measuring 5 proteins at least.
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spelling Immunonephelometry in cyclosporin therapyCiclosporinaImmunonefelometriaCyclosporin is the most effective drug in human allogenic graf survival. Hypertrichosis, gingival hypertrophy, hypertension, hepatotoxicity have been observed but nephrotocicity seems to be the main problem. Cyclosporine activity seems to be related with peripherical lymphocytes, intraocular levels in systemic administration are not effective, and topical treatment appears to be only useful in corneal disease. Cyclosporine blood levels are important to evaluate intestinal absortion, as well as nephrotoxicity is related with blood levels. Aqueous protein levels are related with inflammatory events in uveitis, and can be easily measured in diary clinic by computorized nephelometry; albumin can be a good reference of blood aqueous barrier “in vivo” with alpha antitripsin directly reflecting inflammatory activity. Evaluation of cyclosporin therapy can be done with only one aqueous tap of 50-100ul and measuring 5 proteins at least.1990info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://hdl.handle.net/10316/25476https://hdl.handle.net/10316/25476engPereira-Neves, L.Ribeiro da Silva, J.Prata, L.Santos Rosa, M.Mota-Pinto, A.info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2020-08-28T13:25:01Zoai:estudogeral.uc.pt:10316/25476Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T04:55:02.339656Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Immunonephelometry in cyclosporin therapy
title Immunonephelometry in cyclosporin therapy
spellingShingle Immunonephelometry in cyclosporin therapy
Pereira-Neves, L.
Ciclosporina
Immunonefelometria
title_short Immunonephelometry in cyclosporin therapy
title_full Immunonephelometry in cyclosporin therapy
title_fullStr Immunonephelometry in cyclosporin therapy
title_full_unstemmed Immunonephelometry in cyclosporin therapy
title_sort Immunonephelometry in cyclosporin therapy
author Pereira-Neves, L.
author_facet Pereira-Neves, L.
Ribeiro da Silva, J.
Prata, L.
Santos Rosa, M.
Mota-Pinto, A.
author_role author
author2 Ribeiro da Silva, J.
Prata, L.
Santos Rosa, M.
Mota-Pinto, A.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Pereira-Neves, L.
Ribeiro da Silva, J.
Prata, L.
Santos Rosa, M.
Mota-Pinto, A.
dc.subject.por.fl_str_mv Ciclosporina
Immunonefelometria
topic Ciclosporina
Immunonefelometria
description Cyclosporin is the most effective drug in human allogenic graf survival. Hypertrichosis, gingival hypertrophy, hypertension, hepatotoxicity have been observed but nephrotocicity seems to be the main problem. Cyclosporine activity seems to be related with peripherical lymphocytes, intraocular levels in systemic administration are not effective, and topical treatment appears to be only useful in corneal disease. Cyclosporine blood levels are important to evaluate intestinal absortion, as well as nephrotoxicity is related with blood levels. Aqueous protein levels are related with inflammatory events in uveitis, and can be easily measured in diary clinic by computorized nephelometry; albumin can be a good reference of blood aqueous barrier “in vivo” with alpha antitripsin directly reflecting inflammatory activity. Evaluation of cyclosporin therapy can be done with only one aqueous tap of 50-100ul and measuring 5 proteins at least.
publishDate 1990
dc.date.none.fl_str_mv 1990
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv https://hdl.handle.net/10316/25476
https://hdl.handle.net/10316/25476
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dc.language.iso.fl_str_mv eng
language eng
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dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
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instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
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reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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