Targeting cancer resistance via multifunctional gold nanoparticles
| Main Author: | |
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| Publication Date: | 2019 |
| Other Authors: | , , , , , , , , |
| Format: | Article |
| Language: | eng |
| Source: | Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
| Download full: | http://hdl.handle.net/10362/107254 |
Summary: | POCI-01-0145-FEDER-007728 SFRH/BD/120030/2016 PD/BD/105734/2014 Pest-OE/UID/DTP/04138/2013 |
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Targeting cancer resistance via multifunctional gold nanoparticlesCancerCancer resistanceGold nanoparticlesNanomedicineCatalysisMolecular BiologySpectroscopyComputer Science ApplicationsPhysical and Theoretical ChemistryOrganic ChemistryInorganic ChemistrySDG 3 - Good Health and Well-beingPOCI-01-0145-FEDER-007728 SFRH/BD/120030/2016 PD/BD/105734/2014 Pest-OE/UID/DTP/04138/2013Resistance to chemotherapy is a major problem facing current cancer therapy, which is continuously aiming at the development of new compounds that are capable of tackling tumors that developed resistance toward common chemotherapeutic agents, such as doxorubicin (DOX). Alongside the development of new generations of compounds, nanotechnology-based delivery strategies can significantly improve the in vivo drug stability and target specificity for overcoming drug resistance. In this study, multifunctional gold nanoparticles (AuNP) have been used as a nanoplatform for the targeted delivery of an original anticancer agent, a Zn(II) coordination compound [Zn(DION)2]Cl2 (ZnD), toward better efficacy against DOX-resistant colorectal carcinoma cells (HCT116 DR). Selective delivery of the ZnD nanosystem to cancer cells was achieved by active targeting via cetuximab, NanoZnD, which significantly inhibited cell proliferation and triggered the death of resistant tumor cells, thus improving efficacy. In vivo studies in a colorectal DOX-resistant model corroborated the capability of NanoZnD for the selective targeting of cancer cells, leading to a reduction of tumor growth without systemic toxicity. This approach highlights the potential of gold nanoformulations for the targeting of drug-resistant cancer cells.UCIBIO - Applied Molecular Biosciences UnitDCV - Departamento de Ciências da VidaRUNPedrosa, PedroCorvo, M. LuísaFerreira-Silva, MargaridaMartins, PedroCarvalheiro, Manuela CollaCosta, Pedro M.Martins, CarlaMartins, L. M. D. R. S.Baptista, Pedro V.Fernandes, Alexandra R.2020-11-16T23:58:27Z2019-112019-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/107254eng1661-6596PURE: 19000313https://doi.org/10.3390/ijms20215510info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T17:48:45Zoai:run.unl.pt:10362/107254Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:19:51.241520Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse |
| dc.title.none.fl_str_mv |
Targeting cancer resistance via multifunctional gold nanoparticles |
| title |
Targeting cancer resistance via multifunctional gold nanoparticles |
| spellingShingle |
Targeting cancer resistance via multifunctional gold nanoparticles Pedrosa, Pedro Cancer Cancer resistance Gold nanoparticles Nanomedicine Catalysis Molecular Biology Spectroscopy Computer Science Applications Physical and Theoretical Chemistry Organic Chemistry Inorganic Chemistry SDG 3 - Good Health and Well-being |
| title_short |
Targeting cancer resistance via multifunctional gold nanoparticles |
| title_full |
Targeting cancer resistance via multifunctional gold nanoparticles |
| title_fullStr |
Targeting cancer resistance via multifunctional gold nanoparticles |
| title_full_unstemmed |
Targeting cancer resistance via multifunctional gold nanoparticles |
| title_sort |
Targeting cancer resistance via multifunctional gold nanoparticles |
| author |
Pedrosa, Pedro |
| author_facet |
Pedrosa, Pedro Corvo, M. Luísa Ferreira-Silva, Margarida Martins, Pedro Carvalheiro, Manuela Colla Costa, Pedro M. Martins, Carla Martins, L. M. D. R. S. Baptista, Pedro V. Fernandes, Alexandra R. |
| author_role |
author |
| author2 |
Corvo, M. Luísa Ferreira-Silva, Margarida Martins, Pedro Carvalheiro, Manuela Colla Costa, Pedro M. Martins, Carla Martins, L. M. D. R. S. Baptista, Pedro V. Fernandes, Alexandra R. |
| author2_role |
author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
UCIBIO - Applied Molecular Biosciences Unit DCV - Departamento de Ciências da Vida RUN |
| dc.contributor.author.fl_str_mv |
Pedrosa, Pedro Corvo, M. Luísa Ferreira-Silva, Margarida Martins, Pedro Carvalheiro, Manuela Colla Costa, Pedro M. Martins, Carla Martins, L. M. D. R. S. Baptista, Pedro V. Fernandes, Alexandra R. |
| dc.subject.por.fl_str_mv |
Cancer Cancer resistance Gold nanoparticles Nanomedicine Catalysis Molecular Biology Spectroscopy Computer Science Applications Physical and Theoretical Chemistry Organic Chemistry Inorganic Chemistry SDG 3 - Good Health and Well-being |
| topic |
Cancer Cancer resistance Gold nanoparticles Nanomedicine Catalysis Molecular Biology Spectroscopy Computer Science Applications Physical and Theoretical Chemistry Organic Chemistry Inorganic Chemistry SDG 3 - Good Health and Well-being |
| description |
POCI-01-0145-FEDER-007728 SFRH/BD/120030/2016 PD/BD/105734/2014 Pest-OE/UID/DTP/04138/2013 |
| publishDate |
2019 |
| dc.date.none.fl_str_mv |
2019-11 2019-11-01T00:00:00Z 2020-11-16T23:58:27Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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http://hdl.handle.net/10362/107254 |
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eng |
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eng |
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1661-6596 PURE: 19000313 https://doi.org/10.3390/ijms20215510 |
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