Intravitreal Ranibizumab or Aflibercept after Bevacizumab in diabetic macular edema: exploratory retrospective analysis

Bibliographic Details
Main Author: Pessoa, Bernardete
Publication Date: 2021
Other Authors: Malheiro, Luísa, Carneiro, Inês, Monteiro, Sílvia, Coelho, João, Coelho, Constança, Figueira, João, Meireles, Angelina, Melo Beirão, João Nuno
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10451/54052
Summary: © 2021 Pessoa et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms. php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
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spelling Intravitreal Ranibizumab or Aflibercept after Bevacizumab in diabetic macular edema: exploratory retrospective analysisAfliberceptBevacizumabDiabetic macular edemaRanibizumabRefractory© 2021 Pessoa et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms. php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).Aim: To evaluate the efficacy of switching from bevacizumab to ranibizumab or aflibercept in eyes with diabetic macular edema (DME) unresponsive to bevacizumab. Methods: Single-center retrospective comparative study of patients with DME unresponsive to intravitreal bevacizumab that was switched to ranibizumab or aflibercept. Best-corrected visual acuity (BCVA) and central foveal thickness (CFT) were analysed prior to and 4 months after the switch. Ocular coherence tomography (OCT) biomarkers were also analysed. Results: Fifty-six eyes from 40 patients were included in the study, 33 eyes switched to ranibizumab and 23 to aflibercept. A significant median CFT decrease was observed in both groups (p<0.001), with no between-group differences. BCVA gain was only significant in the ranibizumab group (p<0.001). None of the pre-baseline or baseline parameters were associated with the response to ranibizumab or aflibercept. Conclusion: In persistent DME unresponsive to bevacizumab, both anatomical and functional improvements were observed with ranibizumab whereas aflibercept only showed an anatomical improvement.Dove PressRepositório da Universidade de LisboaPessoa, BernardeteMalheiro, LuísaCarneiro, InêsMonteiro, SílviaCoelho, JoãoCoelho, ConstançaFigueira, JoãoMeireles, AngelinaMelo Beirão, João Nuno2022-08-03T16:29:30Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/54052engClin Ophthalmol. 2021 Jan 22;15:253-2601177-546710.2147/OPTH.S2806441177-5483info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-17T14:47:28Zoai:repositorio.ulisboa.pt:10451/54052Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T03:24:58.055084Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Intravitreal Ranibizumab or Aflibercept after Bevacizumab in diabetic macular edema: exploratory retrospective analysis
title Intravitreal Ranibizumab or Aflibercept after Bevacizumab in diabetic macular edema: exploratory retrospective analysis
spellingShingle Intravitreal Ranibizumab or Aflibercept after Bevacizumab in diabetic macular edema: exploratory retrospective analysis
Pessoa, Bernardete
Aflibercept
Bevacizumab
Diabetic macular edema
Ranibizumab
Refractory
title_short Intravitreal Ranibizumab or Aflibercept after Bevacizumab in diabetic macular edema: exploratory retrospective analysis
title_full Intravitreal Ranibizumab or Aflibercept after Bevacizumab in diabetic macular edema: exploratory retrospective analysis
title_fullStr Intravitreal Ranibizumab or Aflibercept after Bevacizumab in diabetic macular edema: exploratory retrospective analysis
title_full_unstemmed Intravitreal Ranibizumab or Aflibercept after Bevacizumab in diabetic macular edema: exploratory retrospective analysis
title_sort Intravitreal Ranibizumab or Aflibercept after Bevacizumab in diabetic macular edema: exploratory retrospective analysis
author Pessoa, Bernardete
author_facet Pessoa, Bernardete
Malheiro, Luísa
Carneiro, Inês
Monteiro, Sílvia
Coelho, João
Coelho, Constança
Figueira, João
Meireles, Angelina
Melo Beirão, João Nuno
author_role author
author2 Malheiro, Luísa
Carneiro, Inês
Monteiro, Sílvia
Coelho, João
Coelho, Constança
Figueira, João
Meireles, Angelina
Melo Beirão, João Nuno
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Pessoa, Bernardete
Malheiro, Luísa
Carneiro, Inês
Monteiro, Sílvia
Coelho, João
Coelho, Constança
Figueira, João
Meireles, Angelina
Melo Beirão, João Nuno
dc.subject.por.fl_str_mv Aflibercept
Bevacizumab
Diabetic macular edema
Ranibizumab
Refractory
topic Aflibercept
Bevacizumab
Diabetic macular edema
Ranibizumab
Refractory
description © 2021 Pessoa et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms. php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-01-01T00:00:00Z
2022-08-03T16:29:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/54052
url http://hdl.handle.net/10451/54052
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Clin Ophthalmol. 2021 Jan 22;15:253-260
1177-5467
10.2147/OPTH.S280644
1177-5483
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Dove Press
publisher.none.fl_str_mv Dove Press
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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