"MitoTea": Geranium robertianum L. decoctions decrease blood glucose levels and improve liver mitochondrial oxidative phosphorylation in diabetic Goto-Kakizaki rats

Bibliographic Details
Main Author: Santos, Maria Sancha
Publication Date: 2010
Other Authors: Seiça, Raquel, Sena, Cristina, Nunes, Elsa, Peixoto, Francisco, Ferreira, Fernanda M.
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: https://hdl.handle.net/10316/102758
https://doi.org/10.18388/abp.2010_2424
Summary: Several chemical compounds found in plant products have proven to possess beneficial properties, being currently pointed out due to their pharmacological potential in type 2 diabetes mellitus complications. In this context, we studied the effect of Geranium robertianum L. (herb Robert) leaf decoctions in Goto–Kakizaki (GK) rats, a model of type 2 diabetes. Our results showed that oral administration of G. robertianum leaf decoctions over a period of four weeks lowered the plasma glucose levels in diabetic rats. Furthermore, the treatment with G. robertianum extracts improved liver mitochondrial respiratory parameters (state 3, state 4 and FCCP-stimulated respiration) and increased oxidative phosphorylation efficiency.
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spelling "MitoTea": Geranium robertianum L. decoctions decrease blood glucose levels and improve liver mitochondrial oxidative phosphorylation in diabetic Goto-Kakizaki ratsGoto–Kakizaki (GK) ratstype 2 diabetes mellitusGeranium robertianum L.,Vaccinium myrtillus L.herbal medicineoxidative phosphorylationSeveral chemical compounds found in plant products have proven to possess beneficial properties, being currently pointed out due to their pharmacological potential in type 2 diabetes mellitus complications. In this context, we studied the effect of Geranium robertianum L. (herb Robert) leaf decoctions in Goto–Kakizaki (GK) rats, a model of type 2 diabetes. Our results showed that oral administration of G. robertianum leaf decoctions over a period of four weeks lowered the plasma glucose levels in diabetic rats. Furthermore, the treatment with G. robertianum extracts improved liver mitochondrial respiratory parameters (state 3, state 4 and FCCP-stimulated respiration) and increased oxidative phosphorylation efficiency.2010info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://hdl.handle.net/10316/102758https://hdl.handle.net/10316/102758https://doi.org/10.18388/abp.2010_2424eng1734-154X0001-527XSantos, Maria SanchaSeiça, RaquelSena, CristinaNunes, ElsaPeixoto, FranciscoFerreira, Fernanda M.info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2022-10-12T20:31:20Zoai:estudogeral.uc.pt:10316/102758Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T05:52:21.045799Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv "MitoTea": Geranium robertianum L. decoctions decrease blood glucose levels and improve liver mitochondrial oxidative phosphorylation in diabetic Goto-Kakizaki rats
title "MitoTea": Geranium robertianum L. decoctions decrease blood glucose levels and improve liver mitochondrial oxidative phosphorylation in diabetic Goto-Kakizaki rats
spellingShingle "MitoTea": Geranium robertianum L. decoctions decrease blood glucose levels and improve liver mitochondrial oxidative phosphorylation in diabetic Goto-Kakizaki rats
Santos, Maria Sancha
Goto–Kakizaki (GK) rats
type 2 diabetes mellitus
Geranium robertianum L.,
Vaccinium myrtillus L.
herbal medicine
oxidative phosphorylation
title_short "MitoTea": Geranium robertianum L. decoctions decrease blood glucose levels and improve liver mitochondrial oxidative phosphorylation in diabetic Goto-Kakizaki rats
title_full "MitoTea": Geranium robertianum L. decoctions decrease blood glucose levels and improve liver mitochondrial oxidative phosphorylation in diabetic Goto-Kakizaki rats
title_fullStr "MitoTea": Geranium robertianum L. decoctions decrease blood glucose levels and improve liver mitochondrial oxidative phosphorylation in diabetic Goto-Kakizaki rats
title_full_unstemmed "MitoTea": Geranium robertianum L. decoctions decrease blood glucose levels and improve liver mitochondrial oxidative phosphorylation in diabetic Goto-Kakizaki rats
title_sort "MitoTea": Geranium robertianum L. decoctions decrease blood glucose levels and improve liver mitochondrial oxidative phosphorylation in diabetic Goto-Kakizaki rats
author Santos, Maria Sancha
author_facet Santos, Maria Sancha
Seiça, Raquel
Sena, Cristina
Nunes, Elsa
Peixoto, Francisco
Ferreira, Fernanda M.
author_role author
author2 Seiça, Raquel
Sena, Cristina
Nunes, Elsa
Peixoto, Francisco
Ferreira, Fernanda M.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Santos, Maria Sancha
Seiça, Raquel
Sena, Cristina
Nunes, Elsa
Peixoto, Francisco
Ferreira, Fernanda M.
dc.subject.por.fl_str_mv Goto–Kakizaki (GK) rats
type 2 diabetes mellitus
Geranium robertianum L.,
Vaccinium myrtillus L.
herbal medicine
oxidative phosphorylation
topic Goto–Kakizaki (GK) rats
type 2 diabetes mellitus
Geranium robertianum L.,
Vaccinium myrtillus L.
herbal medicine
oxidative phosphorylation
description Several chemical compounds found in plant products have proven to possess beneficial properties, being currently pointed out due to their pharmacological potential in type 2 diabetes mellitus complications. In this context, we studied the effect of Geranium robertianum L. (herb Robert) leaf decoctions in Goto–Kakizaki (GK) rats, a model of type 2 diabetes. Our results showed that oral administration of G. robertianum leaf decoctions over a period of four weeks lowered the plasma glucose levels in diabetic rats. Furthermore, the treatment with G. robertianum extracts improved liver mitochondrial respiratory parameters (state 3, state 4 and FCCP-stimulated respiration) and increased oxidative phosphorylation efficiency.
publishDate 2010
dc.date.none.fl_str_mv 2010
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/10316/102758
https://hdl.handle.net/10316/102758
https://doi.org/10.18388/abp.2010_2424
url https://hdl.handle.net/10316/102758
https://doi.org/10.18388/abp.2010_2424
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1734-154X
0001-527X
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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