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Minimal information for studies of extracellular vesicles (MISEV2023)

Bibliographic Details
Main Author: MISEV Consortium
Publication Date: 2024
Other Authors: Gabriel , AM, Silva, Andreia M., Pinheiro, Cláudio Alexandre Almeida
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/182738
Summary: Funding Information: The authors thank all members of the international EV research community for their support throughout the process of producing this document. Publisher Copyright: © 2024 The Authors. Journal of Extracellular Vesicles published by Wiley Periodicals, LLC on behalf of the International Society for Extracellular Vesicles.
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spelling Minimal information for studies of extracellular vesicles (MISEV2023)From basic to advanced approachesectosomesexosomesextracellular particlesextracellular vesiclesguidelinesmicroparticlesmicrovesiclesminimal information requirementsMISEVreproducibilityrigorstandardisationHistologyCell BiologyFunding Information: The authors thank all members of the international EV research community for their support throughout the process of producing this document. Publisher Copyright: © 2024 The Authors. Journal of Extracellular Vesicles published by Wiley Periodicals, LLC on behalf of the International Society for Extracellular Vesicles.Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year-on-year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non-vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its ‘Minimal Information for Studies of Extracellular Vesicles’, which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly.Instituto de Tecnologia Química e Biológica António Xavier (ITQB)Instituto de Higiene e Medicina Tropical (IHMT)RUNMISEV ConsortiumGabriel , AMSilva, Andreia M.Pinheiro, Cláudio Alexandre Almeida2025-05-07T21:17:29Z2024-022024-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/182738eng2001-3078PURE: 90625047https://doi.org/10.1002/jev2.12404info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-05-12T01:47:05Zoai:run.unl.pt:10362/182738Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T07:13:46.276479Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Minimal information for studies of extracellular vesicles (MISEV2023)
From basic to advanced approaches
title Minimal information for studies of extracellular vesicles (MISEV2023)
spellingShingle Minimal information for studies of extracellular vesicles (MISEV2023)
MISEV Consortium
ectosomes
exosomes
extracellular particles
extracellular vesicles
guidelines
microparticles
microvesicles
minimal information requirements
MISEV
reproducibility
rigor
standardisation
Histology
Cell Biology
title_short Minimal information for studies of extracellular vesicles (MISEV2023)
title_full Minimal information for studies of extracellular vesicles (MISEV2023)
title_fullStr Minimal information for studies of extracellular vesicles (MISEV2023)
title_full_unstemmed Minimal information for studies of extracellular vesicles (MISEV2023)
title_sort Minimal information for studies of extracellular vesicles (MISEV2023)
author MISEV Consortium
author_facet MISEV Consortium
Gabriel , AM
Silva, Andreia M.
Pinheiro, Cláudio Alexandre Almeida
author_role author
author2 Gabriel , AM
Silva, Andreia M.
Pinheiro, Cláudio Alexandre Almeida
author2_role author
author
author
dc.contributor.none.fl_str_mv Instituto de Tecnologia Química e Biológica António Xavier (ITQB)
Instituto de Higiene e Medicina Tropical (IHMT)
RUN
dc.contributor.author.fl_str_mv MISEV Consortium
Gabriel , AM
Silva, Andreia M.
Pinheiro, Cláudio Alexandre Almeida
dc.subject.por.fl_str_mv ectosomes
exosomes
extracellular particles
extracellular vesicles
guidelines
microparticles
microvesicles
minimal information requirements
MISEV
reproducibility
rigor
standardisation
Histology
Cell Biology
topic ectosomes
exosomes
extracellular particles
extracellular vesicles
guidelines
microparticles
microvesicles
minimal information requirements
MISEV
reproducibility
rigor
standardisation
Histology
Cell Biology
description Funding Information: The authors thank all members of the international EV research community for their support throughout the process of producing this document. Publisher Copyright: © 2024 The Authors. Journal of Extracellular Vesicles published by Wiley Periodicals, LLC on behalf of the International Society for Extracellular Vesicles.
publishDate 2024
dc.date.none.fl_str_mv 2024-02
2024-02-01T00:00:00Z
2025-05-07T21:17:29Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/182738
url http://hdl.handle.net/10362/182738
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2001-3078
PURE: 90625047
https://doi.org/10.1002/jev2.12404
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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