Autism spectrum disorder and macrocephaly: a systematic review and meta-analysis

Bibliographic Details
Main Author: Sousa, Joana Margarida Rodrigues e
Publication Date: 2016
Format: Master thesis
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: https://hdl.handle.net/10316/36792
Summary: Trabalho final do 6º ano médico com vista à atribuição do grau de mestre (área científica de pediatria), apresentado à Faculdade de Medicina da Universidade de Coimbra.
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spelling Autism spectrum disorder and macrocephaly: a systematic review and meta-analysisAutism Spectrum DisorderAutismMacrocephalyHead circumferenceTrabalho final do 6º ano médico com vista à atribuição do grau de mestre (área científica de pediatria), apresentado à Faculdade de Medicina da Universidade de Coimbra.Autism spectrum disorder (ASD) is a complex heterogeneous neurodevelopmental disorder. Macrocephaly frequency in ASD is higher than in typically developing peers and one of the most consistent findings. We performed a systematic review and meta-analysis of studies measuring head circumference in ASD children samples. We identified 196 studies through searching strategy and selected 28 studies to include in the meta-analyses. We performed a meta-analysis from a total of 828 children (out of 5185 with ASD) founded with macrocephaly in those 28 studies. The percentage of macrocephaly in the ASD children sample was significantly higher than the expected to general population (95% confidence interval found for ASD children was [14.7, 21.2] versus 3%, respectively). This result supports macrocephaly as a potential biomarker of ASD with implications in future clinical research.2016info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesishttps://hdl.handle.net/10316/36792https://hdl.handle.net/10316/36792engSousa, Joana Margarida Rodrigues einfo:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2022-01-20T17:48:42Zoai:estudogeral.uc.pt:10316/36792Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T04:55:54.636468Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Autism spectrum disorder and macrocephaly: a systematic review and meta-analysis
title Autism spectrum disorder and macrocephaly: a systematic review and meta-analysis
spellingShingle Autism spectrum disorder and macrocephaly: a systematic review and meta-analysis
Sousa, Joana Margarida Rodrigues e
Autism Spectrum Disorder
Autism
Macrocephaly
Head circumference
title_short Autism spectrum disorder and macrocephaly: a systematic review and meta-analysis
title_full Autism spectrum disorder and macrocephaly: a systematic review and meta-analysis
title_fullStr Autism spectrum disorder and macrocephaly: a systematic review and meta-analysis
title_full_unstemmed Autism spectrum disorder and macrocephaly: a systematic review and meta-analysis
title_sort Autism spectrum disorder and macrocephaly: a systematic review and meta-analysis
author Sousa, Joana Margarida Rodrigues e
author_facet Sousa, Joana Margarida Rodrigues e
author_role author
dc.contributor.author.fl_str_mv Sousa, Joana Margarida Rodrigues e
dc.subject.por.fl_str_mv Autism Spectrum Disorder
Autism
Macrocephaly
Head circumference
topic Autism Spectrum Disorder
Autism
Macrocephaly
Head circumference
description Trabalho final do 6º ano médico com vista à atribuição do grau de mestre (área científica de pediatria), apresentado à Faculdade de Medicina da Universidade de Coimbra.
publishDate 2016
dc.date.none.fl_str_mv 2016
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/10316/36792
https://hdl.handle.net/10316/36792
url https://hdl.handle.net/10316/36792
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833602196105592832

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