Liposomes in tissue engineering and regenerative medicine

Bibliographic Details
Main Author: Monteiro, Nelson
Publication Date: 2014
Other Authors: Martins, Albino, Reis, R. L., Neves, N. M.
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/1822/33175
Summary: Liposomes are vesicular structures made of lipids that are formed in aqueous solutions. Structurally, they resemble the lipid membrane of living cells. Therefore, they have been widely investigated, since the 1960s, as models to study the cell membrane, and as carriers for protection and/or delivery of bioactive agents. They have been used in different areas of research including vaccines, imaging, applications in cosmetics and tissue engineering. Tissue engineering is defined as a strategy for promoting the regeneration of tissues for the human body. This strategy may involve the coordinated application of defined cell types with structured biomaterial scaffolds to produce living structures. To create a new tissue, based on this strategy, a controlled stimulation of cultured cells is needed, through a systematic combination of bioactive agents and mechanical signals. In this review, we highlight the potential role of liposomes as a platform for the sustained and local delivery of bioactive agents for tissue engineering and regenerative medicine approaches. liposomesscaffoldsdelivery systemsbioactive agentsstem cells
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spelling Liposomes in tissue engineering and regenerative medicineBioactive agentsDelivery systemsLiposomesScaffoldsStem cellsScience & TechnologyLiposomes are vesicular structures made of lipids that are formed in aqueous solutions. Structurally, they resemble the lipid membrane of living cells. Therefore, they have been widely investigated, since the 1960s, as models to study the cell membrane, and as carriers for protection and/or delivery of bioactive agents. They have been used in different areas of research including vaccines, imaging, applications in cosmetics and tissue engineering. Tissue engineering is defined as a strategy for promoting the regeneration of tissues for the human body. This strategy may involve the coordinated application of defined cell types with structured biomaterial scaffolds to produce living structures. To create a new tissue, based on this strategy, a controlled stimulation of cultured cells is needed, through a systematic combination of bioactive agents and mechanical signals. In this review, we highlight the potential role of liposomes as a platform for the sustained and local delivery of bioactive agents for tissue engineering and regenerative medicine approaches. liposomesscaffoldsdelivery systemsbioactive agentsstem cellsThe authors thank the Portuguese Foundation for Science and Technology for the PhD grant to N.S.M. (SFRH/BD/62465/2009), the post-doctoral grants of A.M. (SFRH/BPD/73663/2010). This study was also partly supported by POLARIS (FP7-REGPOT-2012-2013-1), RL3-TECT-NORTE-01-0124-FEDER-000020, co-financed by the North Portugal Regional Operational Programme (ON.2-O Novo Norte), under the National Strategic Reference Framework (NSRF), through the European Regional Development Fund (ERDF), the OsteoGraphy (PTDC/EME-MFE/2008) and MaxBone (PTDC/SAU-ENB/115179/2009) projects.Royal SocietyUniversidade do MinhoMonteiro, NelsonMartins, AlbinoReis, R. L.Neves, N. M.2014-102014-10-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/33175engMonteiro N., Martins A., Reis R. L., Neves N. M. Liposomes in tissue engineering and regenerative medicine, Journal of the Royal Society Interface, Vol. 11, Issue 101, pp. 20140459, doi:10.1098/rsif.2014.0459, 20141742-568910.1098/rsif.2014.045925401172info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-11T04:41:31Zoai:repositorium.sdum.uminho.pt:1822/33175Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T14:55:47.399465Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Liposomes in tissue engineering and regenerative medicine
title Liposomes in tissue engineering and regenerative medicine
spellingShingle Liposomes in tissue engineering and regenerative medicine
Monteiro, Nelson
Bioactive agents
Delivery systems
Liposomes
Scaffolds
Stem cells
Science & Technology
title_short Liposomes in tissue engineering and regenerative medicine
title_full Liposomes in tissue engineering and regenerative medicine
title_fullStr Liposomes in tissue engineering and regenerative medicine
title_full_unstemmed Liposomes in tissue engineering and regenerative medicine
title_sort Liposomes in tissue engineering and regenerative medicine
author Monteiro, Nelson
author_facet Monteiro, Nelson
Martins, Albino
Reis, R. L.
Neves, N. M.
author_role author
author2 Martins, Albino
Reis, R. L.
Neves, N. M.
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Monteiro, Nelson
Martins, Albino
Reis, R. L.
Neves, N. M.
dc.subject.por.fl_str_mv Bioactive agents
Delivery systems
Liposomes
Scaffolds
Stem cells
Science & Technology
topic Bioactive agents
Delivery systems
Liposomes
Scaffolds
Stem cells
Science & Technology
description Liposomes are vesicular structures made of lipids that are formed in aqueous solutions. Structurally, they resemble the lipid membrane of living cells. Therefore, they have been widely investigated, since the 1960s, as models to study the cell membrane, and as carriers for protection and/or delivery of bioactive agents. They have been used in different areas of research including vaccines, imaging, applications in cosmetics and tissue engineering. Tissue engineering is defined as a strategy for promoting the regeneration of tissues for the human body. This strategy may involve the coordinated application of defined cell types with structured biomaterial scaffolds to produce living structures. To create a new tissue, based on this strategy, a controlled stimulation of cultured cells is needed, through a systematic combination of bioactive agents and mechanical signals. In this review, we highlight the potential role of liposomes as a platform for the sustained and local delivery of bioactive agents for tissue engineering and regenerative medicine approaches. liposomesscaffoldsdelivery systemsbioactive agentsstem cells
publishDate 2014
dc.date.none.fl_str_mv 2014-10
2014-10-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/33175
url http://hdl.handle.net/1822/33175
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Monteiro N., Martins A., Reis R. L., Neves N. M. Liposomes in tissue engineering and regenerative medicine, Journal of the Royal Society Interface, Vol. 11, Issue 101, pp. 20140459, doi:10.1098/rsif.2014.0459, 2014
1742-5689
10.1098/rsif.2014.0459
25401172
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Royal Society
publisher.none.fl_str_mv Royal Society
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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