Advances on gradient scaffolds for osteochondral tissue engineering

Bibliographic Details
Main Author: Oliveira, Joaquim M.
Publication Date: 2021
Other Authors: Ribeiro, Viviana Pinto, Reis, R. L.
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: https://hdl.handle.net/1822/88783
Summary: The osteochondral (OC) tissue is one of the most hierarchical and complex structures known and it is composed by two main compartments of hyaline articular cartilage and subchondral bone. It exhibits unique cellular and molecular transitions from the cartilage to the bone layers. OC diseases such as osteoarthritis and traumatic lesions may affect the articular cartilage, calcified cartilage (interface region) and subchondral bone, thus posing great regenerative challenges. Tissue engineering (TE) principles can offer novel technologies and combinatorial approaches that can better recapitulate the biological OC challenges and complexity in terms of biochemical, mechanical, structural and metabolic gradients, and ultimately can provide biofunctional 3D scaffolds with high reproducibility, versatility and adaptability to each patientâ s needs, as it occurs in OC tissue defects. The recent reports and future directions dealing with gradient scaffolds for OCTE strategies are overviewed herein. A special focus on clinical translation/regulatory approval is given.
id RCAP_42bd59b3937abcbc58ec36f70e74f71c
oai_identifier_str oai:repositorium.sdum.uminho.pt:1822/88783
network_acronym_str RCAP
network_name_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository_id_str https://opendoar.ac.uk/repository/7160
spelling Advances on gradient scaffolds for osteochondral tissue engineeringBiomaterialsGradientsOsteochondralScaffoldsStem cellsTissue engineeringScience & TechnologyThe osteochondral (OC) tissue is one of the most hierarchical and complex structures known and it is composed by two main compartments of hyaline articular cartilage and subchondral bone. It exhibits unique cellular and molecular transitions from the cartilage to the bone layers. OC diseases such as osteoarthritis and traumatic lesions may affect the articular cartilage, calcified cartilage (interface region) and subchondral bone, thus posing great regenerative challenges. Tissue engineering (TE) principles can offer novel technologies and combinatorial approaches that can better recapitulate the biological OC challenges and complexity in terms of biochemical, mechanical, structural and metabolic gradients, and ultimately can provide biofunctional 3D scaffolds with high reproducibility, versatility and adaptability to each patientâ s needs, as it occurs in OC tissue defects. The recent reports and future directions dealing with gradient scaffolds for OCTE strategies are overviewed herein. A special focus on clinical translation/regulatory approval is given.The authors thank the financial support provided by the EU-EC through the BAMOS project (H2020-MSCA-RISE-2016-734156). Viviana P Ribeiro acknowledge for the Junior Researcher contract (POCI-01-0145-FEDER-031367) attributed by the Portuguese Foundation for Science and Technology to Fun4TE project (PTDC/EMD-EMD/31367/2017).IOP PublishingUniversidade do MinhoOliveira, Joaquim M.Ribeiro, Viviana PintoReis, R. L.2021-052021-05-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/88783engOliveira J. M., Ribeiro V. P., Reis R. L. Advances on gradient scaffolds for osteochondral tissue engineering, Progress in Biomedical Engineering, Vol. 3, pp. 033001, doi:10.1088/2516-1091/abfc2c, 20212516-109110.1088/2516-1091/abfc2chttps://doi.org/10.1088/2516-1091/abfc2cinfo:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-11T06:00:45Zoai:repositorium.sdum.uminho.pt:1822/88783Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T15:38:02.514611Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Advances on gradient scaffolds for osteochondral tissue engineering
title Advances on gradient scaffolds for osteochondral tissue engineering
spellingShingle Advances on gradient scaffolds for osteochondral tissue engineering
Oliveira, Joaquim M.
Biomaterials
Gradients
Osteochondral
Scaffolds
Stem cells
Tissue engineering
Science & Technology
title_short Advances on gradient scaffolds for osteochondral tissue engineering
title_full Advances on gradient scaffolds for osteochondral tissue engineering
title_fullStr Advances on gradient scaffolds for osteochondral tissue engineering
title_full_unstemmed Advances on gradient scaffolds for osteochondral tissue engineering
title_sort Advances on gradient scaffolds for osteochondral tissue engineering
author Oliveira, Joaquim M.
author_facet Oliveira, Joaquim M.
Ribeiro, Viviana Pinto
Reis, R. L.
author_role author
author2 Ribeiro, Viviana Pinto
Reis, R. L.
author2_role author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Oliveira, Joaquim M.
Ribeiro, Viviana Pinto
Reis, R. L.
dc.subject.por.fl_str_mv Biomaterials
Gradients
Osteochondral
Scaffolds
Stem cells
Tissue engineering
Science & Technology
topic Biomaterials
Gradients
Osteochondral
Scaffolds
Stem cells
Tissue engineering
Science & Technology
description The osteochondral (OC) tissue is one of the most hierarchical and complex structures known and it is composed by two main compartments of hyaline articular cartilage and subchondral bone. It exhibits unique cellular and molecular transitions from the cartilage to the bone layers. OC diseases such as osteoarthritis and traumatic lesions may affect the articular cartilage, calcified cartilage (interface region) and subchondral bone, thus posing great regenerative challenges. Tissue engineering (TE) principles can offer novel technologies and combinatorial approaches that can better recapitulate the biological OC challenges and complexity in terms of biochemical, mechanical, structural and metabolic gradients, and ultimately can provide biofunctional 3D scaffolds with high reproducibility, versatility and adaptability to each patientâ s needs, as it occurs in OC tissue defects. The recent reports and future directions dealing with gradient scaffolds for OCTE strategies are overviewed herein. A special focus on clinical translation/regulatory approval is given.
publishDate 2021
dc.date.none.fl_str_mv 2021-05
2021-05-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/88783
url https://hdl.handle.net/1822/88783
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Oliveira J. M., Ribeiro V. P., Reis R. L. Advances on gradient scaffolds for osteochondral tissue engineering, Progress in Biomedical Engineering, Vol. 3, pp. 033001, doi:10.1088/2516-1091/abfc2c, 2021
2516-1091
10.1088/2516-1091/abfc2c
https://doi.org/10.1088/2516-1091/abfc2c
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv IOP Publishing
publisher.none.fl_str_mv IOP Publishing
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833595437804683264

Similar Items