First-trimester serum biomarkers in twin pregnancies and adverse obstetric outcomes–a single center cohort study

Bibliographic Details
Main Author: Queirós, Alexandra
Publication Date: 2024
Other Authors: Gomes, Laura, Pereira, Inês, Charepe, Nádia, Plancha, Marta, Rodrigues, Sofia, Cohen, Álvaro, Alves, Marta, Papoila, Ana Luísa, Simões, Teresinha
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/167828
Summary: Publisher Copyright: © The Author(s) 2024.
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network_name_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
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spelling First-trimester serum biomarkers in twin pregnancies and adverse obstetric outcomes–a single center cohort studyFetal growth restrictionFirst trimester screeningHypertensive disordersPreterm birthSerum biomarkersTwin pregnanciesObstetrics and GynaecologyPublisher Copyright: © The Author(s) 2024.Purpose: This study aimed to determine the association of first-trimester maternal serum biomarkers with preterm birth (PTB), fetal growth restriction (FGR) and hypertensive disorders of pregnancy (HDP) in twin pregnancies. Methods: This is a retrospective cohort study of twin pregnancies followed at Maternidade Dr. Alfredo da Costa, Lisbon, Portugal, between January 2010 and December 2022. We included women who completed first-trimester screening in our unit and had ongoing pregnancies with two live fetuses, and delivered after 24 weeks. Maternal characteristics, pregnancy-associated plasma protein-A (PAPP-A) and β-human chorionic gonadotropin (β-hCG) levels were analyzed for different outcomes: small for gestational age (SGA), gestational hypertension (GH), early and late-onset pre-eclampsia (PE), as well as the composite outcome of PTB associated with FGR and/or HDP. Univariable, multivariable logistic regression analyses and receiver-operating characteristic curve were used. Results: 466 twin pregnancies met the inclusion criteria. Overall, 185 (39.7%) pregnancies were affected by SGA < 5th percentile and/or HDP. PAPP-A demonstrated a linear association with gestational age at birth and mean birth weight. PAPP-A proved to be an independent risk factor for SGA and PTB (< 34 and < 36 weeks) related to FGR and/or HDP. None of the women with PAPP-A MoM > 90th percentile developed early-onset PE or PTB < 34 weeks. Conclusion: A high serum PAPP-A (> 90th percentile) ruled out early-onset PE and PTB < 34 weeks. Unless other major risk factors for hypertensive disorders are present, these women should not be considered candidates for aspirin prophylaxis. Nevertheless, close monitoring of all TwP for adverse obstetric outcomes is still recommended.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNQueirós, AlexandraGomes, LauraPereira, InêsCharepe, NádiaPlancha, MartaRodrigues, SofiaCohen, ÁlvaroAlves, MartaPapoila, Ana LuísaSimões, Teresinha2024-05-25T01:04:04Z2024-072024-07-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/167828eng0932-0067PURE: 91793378https://doi.org/10.1007/s00404-024-07547-6info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-11-11T01:38:38Zoai:run.unl.pt:10362/167828Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:52:31.343471Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv First-trimester serum biomarkers in twin pregnancies and adverse obstetric outcomes–a single center cohort study
title First-trimester serum biomarkers in twin pregnancies and adverse obstetric outcomes–a single center cohort study
spellingShingle First-trimester serum biomarkers in twin pregnancies and adverse obstetric outcomes–a single center cohort study
Queirós, Alexandra
Fetal growth restriction
First trimester screening
Hypertensive disorders
Preterm birth
Serum biomarkers
Twin pregnancies
Obstetrics and Gynaecology
title_short First-trimester serum biomarkers in twin pregnancies and adverse obstetric outcomes–a single center cohort study
title_full First-trimester serum biomarkers in twin pregnancies and adverse obstetric outcomes–a single center cohort study
title_fullStr First-trimester serum biomarkers in twin pregnancies and adverse obstetric outcomes–a single center cohort study
title_full_unstemmed First-trimester serum biomarkers in twin pregnancies and adverse obstetric outcomes–a single center cohort study
title_sort First-trimester serum biomarkers in twin pregnancies and adverse obstetric outcomes–a single center cohort study
author Queirós, Alexandra
author_facet Queirós, Alexandra
Gomes, Laura
Pereira, Inês
Charepe, Nádia
Plancha, Marta
Rodrigues, Sofia
Cohen, Álvaro
Alves, Marta
Papoila, Ana Luísa
Simões, Teresinha
author_role author
author2 Gomes, Laura
Pereira, Inês
Charepe, Nádia
Plancha, Marta
Rodrigues, Sofia
Cohen, Álvaro
Alves, Marta
Papoila, Ana Luísa
Simões, Teresinha
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Queirós, Alexandra
Gomes, Laura
Pereira, Inês
Charepe, Nádia
Plancha, Marta
Rodrigues, Sofia
Cohen, Álvaro
Alves, Marta
Papoila, Ana Luísa
Simões, Teresinha
dc.subject.por.fl_str_mv Fetal growth restriction
First trimester screening
Hypertensive disorders
Preterm birth
Serum biomarkers
Twin pregnancies
Obstetrics and Gynaecology
topic Fetal growth restriction
First trimester screening
Hypertensive disorders
Preterm birth
Serum biomarkers
Twin pregnancies
Obstetrics and Gynaecology
description Publisher Copyright: © The Author(s) 2024.
publishDate 2024
dc.date.none.fl_str_mv 2024-05-25T01:04:04Z
2024-07
2024-07-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/167828
url http://hdl.handle.net/10362/167828
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0932-0067
PURE: 91793378
https://doi.org/10.1007/s00404-024-07547-6
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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