Pancreatic Stone Protein in patients with liver failure
| Main Author: | |
|---|---|
| Publication Date: | 2025 |
| Other Authors: | , , , , , , , , , , |
| Format: | Article |
| Language: | eng |
| Source: | Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
| Download full: | http://hdl.handle.net/10362/182056 |
Summary: | Funding Information: We want to acknowledge the whole ICU, Transplant Unit, and General Surgery ward staff for their support in the collection of samples, Marta Alves, MSc (NOVA Medical School) for her support on statistics, and Abionic SA. Publisher Copyright: © 2025 Société Française d'Anesthésie et de Réanimation (SFAR) |
| id |
RCAP_40c2f16337f855c5b2bbe719e31d30ef |
|---|---|
| oai_identifier_str |
oai:run.unl.pt:10362/182056 |
| network_acronym_str |
RCAP |
| network_name_str |
Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
| repository_id_str |
https://opendoar.ac.uk/repository/7160 |
| spelling |
Pancreatic Stone Protein in patients with liver failureA prospective pilot cohort studyAcute liver failureAcute-on-chronic liver failureBiomarkerInfectionPancreatic stone proteinSepsisCritical Care and Intensive Care MedicineAnesthesiology and Pain MedicineFunding Information: We want to acknowledge the whole ICU, Transplant Unit, and General Surgery ward staff for their support in the collection of samples, Marta Alves, MSc (NOVA Medical School) for her support on statistics, and Abionic SA. Publisher Copyright: © 2025 Société Française d'Anesthésie et de Réanimation (SFAR)Background: Pancreatic Stone Protein (PSP) seems to have higher accuracy for sepsis detection compared to other biomarkers. As PSP has never been studied in patients with liver failure (LF), our purpose was to assess its accuracy for diagnosis of infection and prognosis in this population. Methods: We conducted a prospective pilot cohort study on patients with LF consecutively admitted to the Intensive Care Unit of a liver transplant center in 2021−2023. Ongoing overt infection was an exclusion criterion. Daily measurements of biomarkers were performed until discharge, death, or for 21 days. Analysis was performed by adjusting the baseline for the first infection episode (median on D3), which was the reference for those non-infected. Results: Sixteen patients were included, 7 with acute and 9 with acute-on-chronic LF. Median age was 54 (interquartile range 42−64) years, half were female, with admission SOFA score of 10 (IQR 8−12). Hospital mortality was 43.8% (n = 7). An infection was observed in 8 patients, who presented non-significantly higher levels of PSP than non-infected ones during follow-up. Levels were higher in non-survivors than survivors (p < 0.05 from D4 on and since the day of infection considering only infected patients). Similarly, patients under renal replacement therapy had higher PSP levels than others (p < 0.05, D2 to D7 after admission). Conclusion: This pilot study provides early insights into PSP kinetics, suggesting a potential role for prognosis in patients with LF. PSP rises in both ALF and ACLF to levels sustainably higher than those expected for healthy adults. Further research is needed to reassess its diagnostic accuracy for infection and redefine cut-offs in this population.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNLopes, DiogoBandovas, João PedroChumbinho, BeatrizSanto, Catarina EspíritoSousa, MónicaFerreira, BernardoVal-Flores, LuisGermano, NunoPereira, RuiCardoso, Filipe S.Bento, LuísPóvoa, Pedro2025-04-10T15:59:09Z2025-042025-04-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/182056eng2352-5568PURE: 114071486https://doi.org/10.1016/j.accpm.2025.101486info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-04-14T01:41:23Zoai:run.unl.pt:10362/182056Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T06:26:00.045368Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse |
| dc.title.none.fl_str_mv |
Pancreatic Stone Protein in patients with liver failure A prospective pilot cohort study |
| title |
Pancreatic Stone Protein in patients with liver failure |
| spellingShingle |
Pancreatic Stone Protein in patients with liver failure Lopes, Diogo Acute liver failure Acute-on-chronic liver failure Biomarker Infection Pancreatic stone protein Sepsis Critical Care and Intensive Care Medicine Anesthesiology and Pain Medicine |
| title_short |
Pancreatic Stone Protein in patients with liver failure |
| title_full |
Pancreatic Stone Protein in patients with liver failure |
| title_fullStr |
Pancreatic Stone Protein in patients with liver failure |
| title_full_unstemmed |
Pancreatic Stone Protein in patients with liver failure |
| title_sort |
Pancreatic Stone Protein in patients with liver failure |
| author |
Lopes, Diogo |
| author_facet |
Lopes, Diogo Bandovas, João Pedro Chumbinho, Beatriz Santo, Catarina Espírito Sousa, Mónica Ferreira, Bernardo Val-Flores, Luis Germano, Nuno Pereira, Rui Cardoso, Filipe S. Bento, Luís Póvoa, Pedro |
| author_role |
author |
| author2 |
Bandovas, João Pedro Chumbinho, Beatriz Santo, Catarina Espírito Sousa, Mónica Ferreira, Bernardo Val-Flores, Luis Germano, Nuno Pereira, Rui Cardoso, Filipe S. Bento, Luís Póvoa, Pedro |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
| dc.contributor.author.fl_str_mv |
Lopes, Diogo Bandovas, João Pedro Chumbinho, Beatriz Santo, Catarina Espírito Sousa, Mónica Ferreira, Bernardo Val-Flores, Luis Germano, Nuno Pereira, Rui Cardoso, Filipe S. Bento, Luís Póvoa, Pedro |
| dc.subject.por.fl_str_mv |
Acute liver failure Acute-on-chronic liver failure Biomarker Infection Pancreatic stone protein Sepsis Critical Care and Intensive Care Medicine Anesthesiology and Pain Medicine |
| topic |
Acute liver failure Acute-on-chronic liver failure Biomarker Infection Pancreatic stone protein Sepsis Critical Care and Intensive Care Medicine Anesthesiology and Pain Medicine |
| description |
Funding Information: We want to acknowledge the whole ICU, Transplant Unit, and General Surgery ward staff for their support in the collection of samples, Marta Alves, MSc (NOVA Medical School) for her support on statistics, and Abionic SA. Publisher Copyright: © 2025 Société Française d'Anesthésie et de Réanimation (SFAR) |
| publishDate |
2025 |
| dc.date.none.fl_str_mv |
2025-04-10T15:59:09Z 2025-04 2025-04-01T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/182056 |
| url |
http://hdl.handle.net/10362/182056 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
2352-5568 PURE: 114071486 https://doi.org/10.1016/j.accpm.2025.101486 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.source.none.fl_str_mv |
reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia instacron:RCAAP |
| instname_str |
FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia |
| instacron_str |
RCAAP |
| institution |
RCAAP |
| reponame_str |
Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
| collection |
Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
| repository.name.fl_str_mv |
Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia |
| repository.mail.fl_str_mv |
info@rcaap.pt |
| _version_ |
1833602683008712704 |