Unravelling protein aggregation as an ageing related process or a neuropathological response

Detalhes bibliográficos
Autor(a) principal: Trigo, Diogo
Data de Publicação: 2019
Outros Autores: Nadais, André, da Cruz E Silva, Odete A. B.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Texto Completo: http://hdl.handle.net/10773/37593
Resumo: Protein aggregation is normally associated with amyloidosis, namely motor neurone, Alzheimer's, Parkinson's or prion diseases. However, recent results have unveiled a concept of gradual increase of protein aggregation associated with the ageing process, apparently not necessarily associated with pathological conditions. Given that protein aggregation is sufficient to activate stress-response and inflammation, impairing protein synthesis and quality control mechanisms, the former is assumed to negatively affect cellular metabolism and behaviour. In this review the state of the art in protein aggregation research is discussed, namely the relationship between pathology and proteostasis. The role of pathology and ageing in overriding protein quality-control mechanisms, and consequently, the effect of these faulty cellular processes on pathological and healthy ageing, are also addressed.
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spelling Unravelling protein aggregation as an ageing related process or a neuropathological responseAgeingAggregationMisfoldingProtein aggregation is normally associated with amyloidosis, namely motor neurone, Alzheimer's, Parkinson's or prion diseases. However, recent results have unveiled a concept of gradual increase of protein aggregation associated with the ageing process, apparently not necessarily associated with pathological conditions. Given that protein aggregation is sufficient to activate stress-response and inflammation, impairing protein synthesis and quality control mechanisms, the former is assumed to negatively affect cellular metabolism and behaviour. In this review the state of the art in protein aggregation research is discussed, namely the relationship between pathology and proteostasis. The role of pathology and ageing in overriding protein quality-control mechanisms, and consequently, the effect of these faulty cellular processes on pathological and healthy ageing, are also addressed.Elsevier2023-05-08T13:48:44Z2019-05-01T00:00:00Z2019-05info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/37593eng1568-163710.1016/j.arr.2019.02.001Trigo, DiogoNadais, Andréda Cruz E Silva, Odete A. B.info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-06T04:45:52Zoai:ria.ua.pt:10773/37593Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T14:19:24.247407Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Unravelling protein aggregation as an ageing related process or a neuropathological response
title Unravelling protein aggregation as an ageing related process or a neuropathological response
spellingShingle Unravelling protein aggregation as an ageing related process or a neuropathological response
Trigo, Diogo
Ageing
Aggregation
Misfolding
title_short Unravelling protein aggregation as an ageing related process or a neuropathological response
title_full Unravelling protein aggregation as an ageing related process or a neuropathological response
title_fullStr Unravelling protein aggregation as an ageing related process or a neuropathological response
title_full_unstemmed Unravelling protein aggregation as an ageing related process or a neuropathological response
title_sort Unravelling protein aggregation as an ageing related process or a neuropathological response
author Trigo, Diogo
author_facet Trigo, Diogo
Nadais, André
da Cruz E Silva, Odete A. B.
author_role author
author2 Nadais, André
da Cruz E Silva, Odete A. B.
author2_role author
author
dc.contributor.author.fl_str_mv Trigo, Diogo
Nadais, André
da Cruz E Silva, Odete A. B.
dc.subject.por.fl_str_mv Ageing
Aggregation
Misfolding
topic Ageing
Aggregation
Misfolding
description Protein aggregation is normally associated with amyloidosis, namely motor neurone, Alzheimer's, Parkinson's or prion diseases. However, recent results have unveiled a concept of gradual increase of protein aggregation associated with the ageing process, apparently not necessarily associated with pathological conditions. Given that protein aggregation is sufficient to activate stress-response and inflammation, impairing protein synthesis and quality control mechanisms, the former is assumed to negatively affect cellular metabolism and behaviour. In this review the state of the art in protein aggregation research is discussed, namely the relationship between pathology and proteostasis. The role of pathology and ageing in overriding protein quality-control mechanisms, and consequently, the effect of these faulty cellular processes on pathological and healthy ageing, are also addressed.
publishDate 2019
dc.date.none.fl_str_mv 2019-05-01T00:00:00Z
2019-05
2023-05-08T13:48:44Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10773/37593
url http://hdl.handle.net/10773/37593
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1568-1637
10.1016/j.arr.2019.02.001
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
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reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
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