Emerging tumor spheroids technologies for 3D in vitro cancer modeling

Bibliographic Details
Main Author: Rodrigues, Tânia
Publication Date: 2018
Other Authors: Kundu, Banani, Silva-Correia, Joana, Kundu, Subhas C, Oliveira, J. M., Reis, R. L., Correlo, V. M.
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: https://hdl.handle.net/1822/51321
Summary: "Article in Press, Available online 31 October 2017" ; "S0163-7258(17)30268-1"
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spelling Emerging tumor spheroids technologies for 3D in vitro cancer modelingMetastasis3D Tumor ModelsMulticellular Tumor SpheroidsBioprintingBiomaterialsScience & Technology"Article in Press, Available online 31 October 2017" ; "S0163-7258(17)30268-1"Cancer is a leading cause of mortality and morbidity worldwide. Around 90% of deaths are caused by metastasis and just 10% by primary tumor. The advancement of treatment approaches is not at the same rhythm of the disease; making cancer a focal target of biomedical research. To enhance the understanding and promts the therapeutic delivery; concepts of tissue engineering are applied in the development of in vitro models that can bridge between 2D cell culture and animal models, mimicking tissue microenvironment. Tumor spheroid represents highly suitable 3D organoid-like framework elucidiating the intra and inter cellular signaling of cancer, like that formed in physiological niche. However, spheroids are of limited value in studying critical biological phenomenon such as tumor-stroma interactons involving extra cellular matrix or immune system. Therefore, a compelling need of tailoring spheroid technologies with physiologically relevant biomaterials or in silico models, is ever emerging. The diagnostic and prognostic role of spheroids rearrangements within biomaterials or microfluidic channel is indicative of patient management; particularly for the decision of targated therapy. Fragmented information on available in vitro spheroid models and lack of critical analysis on transformation aspects of these strategies; pushes the urge to comprehensively overview the recent technological advancements (e.g. bioprinting, micro-fluidic technologies or use of biomaterials to attain the third dimension) in the shed of tranlationable cancer research. In present article, relationships between current models and their possible exploitation in clinical success is explored with the highlight of existing challenges in defining therapeutic targets and screening of drug efficacy.The authors are thankful to European Union (Horizon 2020) funded project FoReCaST (No. 668983), the FCT fellowship to J. Silva-Correia (Grant No. SFRH/BPD/100590/2014), distinctions to J.M.O. under the Investigator FCT program (IF/00423/2012) and V.M.C. under the Investigator FCT program (IF/01214/2014) for supporting this work financially.info:eu-repo/semantics/publishedVersionElsevierUniversidade do MinhoRodrigues, TâniaKundu, BananiSilva-Correia, JoanaKundu, Subhas COliveira, J. M.Reis, R. L.Correlo, V. M.20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/51321engRodrigues T., Kundu B., Silva-Correia J., Kundu S. C., Oliveira J. M., Reis R. L., Correlo V. M. Emerging tumor spheroids technologies for 3D in vitro cancer modeling, Pharmacology & Therapeutics, doi:10.1016/j.pharmthera.2017.10.018, 2018.0163-72581879-016X10.1016/j.pharmthera.2017.10.01829097309https://doi.org/10.1016/j.pharmthera.2017.10.018info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-04-12T04:10:52Zoai:repositorium.sdum.uminho.pt:1822/51321Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T14:54:04.823921Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Emerging tumor spheroids technologies for 3D in vitro cancer modeling
title Emerging tumor spheroids technologies for 3D in vitro cancer modeling
spellingShingle Emerging tumor spheroids technologies for 3D in vitro cancer modeling
Rodrigues, Tânia
Metastasis
3D Tumor Models
Multicellular Tumor Spheroids
Bioprinting
Biomaterials
Science & Technology
title_short Emerging tumor spheroids technologies for 3D in vitro cancer modeling
title_full Emerging tumor spheroids technologies for 3D in vitro cancer modeling
title_fullStr Emerging tumor spheroids technologies for 3D in vitro cancer modeling
title_full_unstemmed Emerging tumor spheroids technologies for 3D in vitro cancer modeling
title_sort Emerging tumor spheroids technologies for 3D in vitro cancer modeling
author Rodrigues, Tânia
author_facet Rodrigues, Tânia
Kundu, Banani
Silva-Correia, Joana
Kundu, Subhas C
Oliveira, J. M.
Reis, R. L.
Correlo, V. M.
author_role author
author2 Kundu, Banani
Silva-Correia, Joana
Kundu, Subhas C
Oliveira, J. M.
Reis, R. L.
Correlo, V. M.
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Rodrigues, Tânia
Kundu, Banani
Silva-Correia, Joana
Kundu, Subhas C
Oliveira, J. M.
Reis, R. L.
Correlo, V. M.
dc.subject.por.fl_str_mv Metastasis
3D Tumor Models
Multicellular Tumor Spheroids
Bioprinting
Biomaterials
Science & Technology
topic Metastasis
3D Tumor Models
Multicellular Tumor Spheroids
Bioprinting
Biomaterials
Science & Technology
description "Article in Press, Available online 31 October 2017" ; "S0163-7258(17)30268-1"
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/51321
url https://hdl.handle.net/1822/51321
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Rodrigues T., Kundu B., Silva-Correia J., Kundu S. C., Oliveira J. M., Reis R. L., Correlo V. M. Emerging tumor spheroids technologies for 3D in vitro cancer modeling, Pharmacology & Therapeutics, doi:10.1016/j.pharmthera.2017.10.018, 2018.
0163-7258
1879-016X
10.1016/j.pharmthera.2017.10.018
29097309
https://doi.org/10.1016/j.pharmthera.2017.10.018
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833594966778052608

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