Proteostasis networks in aging: novel insights from text-mining approaches

Detalhes bibliográficos
Autor(a) principal: Neves, Diogo
Data de Publicação: 2023
Outros Autores: Duarte-Pereira, Sara, Matos, Sérgio, Silva, Raquel M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Texto Completo: http://hdl.handle.net/10400.14/40776
Resumo: Aging is a topic of paramount importance in an increasingly elderly society and has been the focus of extensive research. Protein homeostasis (proteostasis) decline is a hallmark in aging and several age-related diseases, but which specific proteins and mechanisms are involved in proteostasis (de)regulation during the aging process remain largely unknown. Here, we used different text-mining tools complemented with protein–protein interaction data to address this complex topic. Analysis of the integrated protein interaction networks identified novel proteins and pathways associated to proteostasis mechanisms and aging or age-related disorders, indicating that this approach is useful to identify previously unknown links and for retrieving information of potential novel biomarkers or therapeutic targets.
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spelling Proteostasis networks in aging: novel insights from text-mining approachesProtein aggregationProtein–protein interactionsInflammasomeNAD metabolismEGASAging is a topic of paramount importance in an increasingly elderly society and has been the focus of extensive research. Protein homeostasis (proteostasis) decline is a hallmark in aging and several age-related diseases, but which specific proteins and mechanisms are involved in proteostasis (de)regulation during the aging process remain largely unknown. Here, we used different text-mining tools complemented with protein–protein interaction data to address this complex topic. Analysis of the integrated protein interaction networks identified novel proteins and pathways associated to proteostasis mechanisms and aging or age-related disorders, indicating that this approach is useful to identify previously unknown links and for retrieving information of potential novel biomarkers or therapeutic targets.VeritatiNeves, DiogoDuarte-Pereira, SaraMatos, SérgioSilva, Raquel M.2023-04-05T13:50:10Z2023-08-012023-08-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.14/40776eng1389-572910.1007/s10522-023-10027-0info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-13T10:34:26Zoai:repositorio.ucp.pt:10400.14/40776Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T01:35:59.067464Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Proteostasis networks in aging: novel insights from text-mining approaches
title Proteostasis networks in aging: novel insights from text-mining approaches
spellingShingle Proteostasis networks in aging: novel insights from text-mining approaches
Neves, Diogo
Protein aggregation
Protein–protein interactions
Inflammasome
NAD metabolism
EGAS
title_short Proteostasis networks in aging: novel insights from text-mining approaches
title_full Proteostasis networks in aging: novel insights from text-mining approaches
title_fullStr Proteostasis networks in aging: novel insights from text-mining approaches
title_full_unstemmed Proteostasis networks in aging: novel insights from text-mining approaches
title_sort Proteostasis networks in aging: novel insights from text-mining approaches
author Neves, Diogo
author_facet Neves, Diogo
Duarte-Pereira, Sara
Matos, Sérgio
Silva, Raquel M.
author_role author
author2 Duarte-Pereira, Sara
Matos, Sérgio
Silva, Raquel M.
author2_role author
author
author
dc.contributor.none.fl_str_mv Veritati
dc.contributor.author.fl_str_mv Neves, Diogo
Duarte-Pereira, Sara
Matos, Sérgio
Silva, Raquel M.
dc.subject.por.fl_str_mv Protein aggregation
Protein–protein interactions
Inflammasome
NAD metabolism
EGAS
topic Protein aggregation
Protein–protein interactions
Inflammasome
NAD metabolism
EGAS
description Aging is a topic of paramount importance in an increasingly elderly society and has been the focus of extensive research. Protein homeostasis (proteostasis) decline is a hallmark in aging and several age-related diseases, but which specific proteins and mechanisms are involved in proteostasis (de)regulation during the aging process remain largely unknown. Here, we used different text-mining tools complemented with protein–protein interaction data to address this complex topic. Analysis of the integrated protein interaction networks identified novel proteins and pathways associated to proteostasis mechanisms and aging or age-related disorders, indicating that this approach is useful to identify previously unknown links and for retrieving information of potential novel biomarkers or therapeutic targets.
publishDate 2023
dc.date.none.fl_str_mv 2023-04-05T13:50:10Z
2023-08-01
2023-08-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.14/40776
url http://hdl.handle.net/10400.14/40776
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1389-5729
10.1007/s10522-023-10027-0
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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