Tuning of paroxetine 3D-printable formulations for fused deposition modelling

• Main Author: Figueiredo, Sara
• Publication Date: 2021
• Other Authors: Pinto, João F., Carvalho, Fátima G., Fernandes, Ana Isabel
• Format: Other
• Language: eng
• Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
• Download full: http://hdl.handle.net/10400.26/40607
• topic: Extrudability; Filament; Printability; 3D-printed tablet; Fused deposition modelling (FDM); Hot melt extrusion (HME); Paroxetine (PRX)

This work reports the preliminary development of paroxetine-containing formulations amenable to hot-melt extrusion coupled to fused deposition modelling-based 3D printing. Polymeric matrices were used alone, or added with processing enhancers (e.g., plasticizer and filler). The polymeric formulation containing paroxetine (30% w/w), hydroxypropylcellulose (54% w/w) and excipients (16% w/w of dicalcium dihydrate phosphate, magnesium stearate and triethylcitrate; 10:1:5 ratio) exhibited the most suitable behaviour to be extruded and 3D printed, proving that adjuvants are critical to ensure processing of the formulations.