The efficacy of antihypertensiye drugs in chronic intermittent hypoxia conditions

Bibliographic Details
Main Author: Diogo, LN
Publication Date: 2014
Other Authors: Monteiro, Emília C.
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/23565
Summary: The authors would like to thank the Portuguese Fundacao para a Ciencia e a Tecnologia (FCT) and CEDOC (Chronic Diseases Research Centre, Lisbon, Portugal). Lucilia N. Diogo is supported by an FCT fellowship (SFRH/BD/48335/2008; PTDC/SAU-TOX/112264/2009).
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spelling The efficacy of antihypertensiye drugs in chronic intermittent hypoxia conditionsantihypertensive drugsCHRONIC EPISODIC HYPOXIASYSTEMIC BLOOD-PRESSURECAROTID BARORECEPTOR STIMULATIONPULMONARY ARTERIAL-HYPERTENSIONRENAL SYMPATHETIC DENERVATIONRANDOMIZED CLINICAL-TRIALOBSTRUCTIVE SLEEP-APNEAPOSITIVE AIRWAY PRESSUREobstructive sleep apneaRESISTANT HYPERTENSIONhypertensionblood pressurechronic intermittent hypoxiaRENIN-ANGIOTENSIN SYSTEMantihypertensive drugsblood pressurechronic intermittent hypoxiahypertensionobstructive sleep apneaQP PhysiologyThe authors would like to thank the Portuguese Fundacao para a Ciencia e a Tecnologia (FCT) and CEDOC (Chronic Diseases Research Centre, Lisbon, Portugal). Lucilia N. Diogo is supported by an FCT fellowship (SFRH/BD/48335/2008; PTDC/SAU-TOX/112264/2009).Sleep apnea/hypopnea disorders include centrally originated diseases and obstructive sleep apnea (OSA). This last condition is renowned as a frequent secondary cause of hypertension (HT). The mechanisms involved in the pathogenesis of HT can be summarized in relation to two main pathways: sympathetic nervous system stimulation mediated mainly by activation of carotid body (CB) chemoreflexes and/or asphyxia, and, by no means the least important, the systemic effects of chronic intermittent hypoxia (CIH). The use of animal models has revealed that CIH is the critical stimulus underlying sympathetic activity and hypertension, and that this effect requires the presence of functional arterial chemoreceptors, which are hyperactive in CIH. These models of CIH mimic the HT observed in humans and allow the study of CIH independently without the mechanical obstruction component. The effect of continuous positive airway pressure (CRAP), the gold standard treatment for OSA patients, to reduce blood pressure seems to be modest and concomitant antihypertensive therapy is still required. We focus this review on the efficacy of pharmacological interventions to revert HT associated with CIH conditions in both animal models and humans. First, we explore the experimental animal models, developed to mimic HT related to CIH, which have been used to investigate the effect of antihypertensive drugs (AHDs). Second, we review what is known about drug efficacy to reverse HT induced by CIH in animals. Moreover, findings in humans with OSA are cited to demonstrate the lack of strong evidence for the establishment of a first-line antihypertensive regimen for these patients. Indeed, specific therapeutic guidelines for the pharmacological treatment of HT in these patients are still lacking. Finally, we discuss the future perspectives concerning the non-pharmacological and pharmacological management of this particular type of HT.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centro de Estudos de Doenças Crónicas (CEDOC)RUNDiogo, LNMonteiro, Emília C.2017-09-25T22:01:14Z2014-092014-09-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article24application/pdfhttp://hdl.handle.net/10362/23565eng1664-042XPURE: 319554https://doi.org/10.3389/fphys.2014.00361info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T17:27:56Zoai:run.unl.pt:10362/23565Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T16:59:06.734325Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv The efficacy of antihypertensiye drugs in chronic intermittent hypoxia conditions
title The efficacy of antihypertensiye drugs in chronic intermittent hypoxia conditions
spellingShingle The efficacy of antihypertensiye drugs in chronic intermittent hypoxia conditions
Diogo, LN
antihypertensive drugs
CHRONIC EPISODIC HYPOXIA
SYSTEMIC BLOOD-PRESSURE
CAROTID BARORECEPTOR STIMULATION
PULMONARY ARTERIAL-HYPERTENSION
RENAL SYMPATHETIC DENERVATION
RANDOMIZED CLINICAL-TRIAL
OBSTRUCTIVE SLEEP-APNEA
POSITIVE AIRWAY PRESSURE
obstructive sleep apnea
RESISTANT HYPERTENSION
hypertension
blood pressure
chronic intermittent hypoxia
RENIN-ANGIOTENSIN SYSTEM
antihypertensive drugs
blood pressure
chronic intermittent hypoxia
hypertension
obstructive sleep apnea
QP Physiology
title_short The efficacy of antihypertensiye drugs in chronic intermittent hypoxia conditions
title_full The efficacy of antihypertensiye drugs in chronic intermittent hypoxia conditions
title_fullStr The efficacy of antihypertensiye drugs in chronic intermittent hypoxia conditions
title_full_unstemmed The efficacy of antihypertensiye drugs in chronic intermittent hypoxia conditions
title_sort The efficacy of antihypertensiye drugs in chronic intermittent hypoxia conditions
author Diogo, LN
author_facet Diogo, LN
Monteiro, Emília C.
author_role author
author2 Monteiro, Emília C.
author2_role author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Centro de Estudos de Doenças Crónicas (CEDOC)
RUN
dc.contributor.author.fl_str_mv Diogo, LN
Monteiro, Emília C.
dc.subject.por.fl_str_mv antihypertensive drugs
CHRONIC EPISODIC HYPOXIA
SYSTEMIC BLOOD-PRESSURE
CAROTID BARORECEPTOR STIMULATION
PULMONARY ARTERIAL-HYPERTENSION
RENAL SYMPATHETIC DENERVATION
RANDOMIZED CLINICAL-TRIAL
OBSTRUCTIVE SLEEP-APNEA
POSITIVE AIRWAY PRESSURE
obstructive sleep apnea
RESISTANT HYPERTENSION
hypertension
blood pressure
chronic intermittent hypoxia
RENIN-ANGIOTENSIN SYSTEM
antihypertensive drugs
blood pressure
chronic intermittent hypoxia
hypertension
obstructive sleep apnea
QP Physiology
topic antihypertensive drugs
CHRONIC EPISODIC HYPOXIA
SYSTEMIC BLOOD-PRESSURE
CAROTID BARORECEPTOR STIMULATION
PULMONARY ARTERIAL-HYPERTENSION
RENAL SYMPATHETIC DENERVATION
RANDOMIZED CLINICAL-TRIAL
OBSTRUCTIVE SLEEP-APNEA
POSITIVE AIRWAY PRESSURE
obstructive sleep apnea
RESISTANT HYPERTENSION
hypertension
blood pressure
chronic intermittent hypoxia
RENIN-ANGIOTENSIN SYSTEM
antihypertensive drugs
blood pressure
chronic intermittent hypoxia
hypertension
obstructive sleep apnea
QP Physiology
description The authors would like to thank the Portuguese Fundacao para a Ciencia e a Tecnologia (FCT) and CEDOC (Chronic Diseases Research Centre, Lisbon, Portugal). Lucilia N. Diogo is supported by an FCT fellowship (SFRH/BD/48335/2008; PTDC/SAU-TOX/112264/2009).
publishDate 2014
dc.date.none.fl_str_mv 2014-09
2014-09-01T00:00:00Z
2017-09-25T22:01:14Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/23565
url http://hdl.handle.net/10362/23565
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1664-042X
PURE: 319554
https://doi.org/10.3389/fphys.2014.00361
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 24
application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833596342223503360

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