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Islet amyloid polypeptide & amyloid beta peptide roles in Alzheimer's disease

Bibliographic Details
Main Author: Ferreira, Sofia
Publication Date: 2020
Other Authors: Raimundo, Ana, Menezes, Regina, Martins, Ivo
Format: Other
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/109431
Summary: Funding: This work was supported by iNOVA4Health – UID/Multi/04462/2019, a program financially supported by Fundação para a Ciência e Tecnologia/ Ministério da Educação e Ciência, through national funds and co-funded by FEDER under the PT2020 Partnership Agreement, Funding from INTERFACE Programme, through the Innovation, Technology and Circular Economy Fund (FITEC), FCT via PTDC/BIA-MOL/31104/2017 and UID/Multi/04462/2019-SubProj iNOVA4Health C44 (to RM), PD/BD/135504/2018 (to AFR), Sociedade Portuguesa de Diabetologia for the Nuno Castelo-Branco Prize – 2016 (to RM), and ICM acknowledges FCT-MCTES Program “Concurso de Estímulo ao Emprego Científico” (CEECIND/01670/2017).
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spelling Islet amyloid polypeptide & amyloid beta peptide roles in Alzheimer's diseaseTwo triggers, one diseaseaggregationAlzheimeramylinamyloiddiabetesislet amyloid polypeptideDevelopmental NeuroscienceSDG 3 - Good Health and Well-beingFunding: This work was supported by iNOVA4Health – UID/Multi/04462/2019, a program financially supported by Fundação para a Ciência e Tecnologia/ Ministério da Educação e Ciência, through national funds and co-funded by FEDER under the PT2020 Partnership Agreement, Funding from INTERFACE Programme, through the Innovation, Technology and Circular Economy Fund (FITEC), FCT via PTDC/BIA-MOL/31104/2017 and UID/Multi/04462/2019-SubProj iNOVA4Health C44 (to RM), PD/BD/135504/2018 (to AFR), Sociedade Portuguesa de Diabetologia for the Nuno Castelo-Branco Prize – 2016 (to RM), and ICM acknowledges FCT-MCTES Program “Concurso de Estímulo ao Emprego Científico” (CEECIND/01670/2017).Alzheimer's disease (AD) is a neurodegenerative disorder that affects millions worldwide. Due to population ageing, the incidence of AD is increasing. AD patients develop cognitive decline and dementia, features for which is known, requiring permanent care. This poses a major socio-economic burden on healthcare systems as AD patients' relatives and healthcare workers are forced to cope with rising numbers of affected people. Despite recent advances, AD pathological mechanisms are not fully understood. Nevertheless, it is clear that the amyloid beta (Aβ) peptide, which forms amyloid plaques in AD patients' brains, plays a key role. Type 2 diabetes, the most common form of diabetes, affects hundreds of million people globally. Islet amyloid polypeptide (IAPP) is a hormone co-produced and secreted with insulin in pancreatic β-cells, with a key role in diabetes, as it helps regulate glucose levels and control adiposity and satiation. Similarly to Aβ, IAPP is very amyloidogenic, generating intracellular amyloid deposits that cause β-cell dysfunction and death. It is now clear that IAPP can also have a pathological role in AD, decreasing cognitive function. IAPP harms the blood-brain barrier, directly interacts and co-deposits with Aβ, promoting diabetes-associated dementia. IAPP can cause a metabolic dysfunction in the brain, leading to other diabetes-related forms of AD. Thus, here we discuss IAPP association with diabetes, Aβ and dementia, in the context of what we designate a 'diabetes brain phenotype' AD hypothesis. Such approach helps to set a conceptual framework for future IAPP-based drugs against AD.Instituto de Tecnologia Química e Biológica António Xavier (ITQB)Centro de Estudos de Doenças Crónicas (CEDOC)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNFerreira, SofiaRaimundo, AnaMenezes, ReginaMartins, Ivo2020-12-29T00:03:45Z2021-062021-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/other4application/pdfhttp://hdl.handle.net/10362/109431eng1673-5374PURE: 27075200https://doi.org/10.4103/1673-5374.300323info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T17:49:35Zoai:run.unl.pt:10362/109431Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:20:55.121805Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Islet amyloid polypeptide & amyloid beta peptide roles in Alzheimer's disease
Two triggers, one disease
title Islet amyloid polypeptide & amyloid beta peptide roles in Alzheimer's disease
spellingShingle Islet amyloid polypeptide & amyloid beta peptide roles in Alzheimer's disease
Ferreira, Sofia
aggregation
Alzheimer
amylin
amyloid
diabetes
islet amyloid polypeptide
Developmental Neuroscience
SDG 3 - Good Health and Well-being
title_short Islet amyloid polypeptide & amyloid beta peptide roles in Alzheimer's disease
title_full Islet amyloid polypeptide & amyloid beta peptide roles in Alzheimer's disease
title_fullStr Islet amyloid polypeptide & amyloid beta peptide roles in Alzheimer's disease
title_full_unstemmed Islet amyloid polypeptide & amyloid beta peptide roles in Alzheimer's disease
title_sort Islet amyloid polypeptide & amyloid beta peptide roles in Alzheimer's disease
author Ferreira, Sofia
author_facet Ferreira, Sofia
Raimundo, Ana
Menezes, Regina
Martins, Ivo
author_role author
author2 Raimundo, Ana
Menezes, Regina
Martins, Ivo
author2_role author
author
author
dc.contributor.none.fl_str_mv Instituto de Tecnologia Química e Biológica António Xavier (ITQB)
Centro de Estudos de Doenças Crónicas (CEDOC)
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Ferreira, Sofia
Raimundo, Ana
Menezes, Regina
Martins, Ivo
dc.subject.por.fl_str_mv aggregation
Alzheimer
amylin
amyloid
diabetes
islet amyloid polypeptide
Developmental Neuroscience
SDG 3 - Good Health and Well-being
topic aggregation
Alzheimer
amylin
amyloid
diabetes
islet amyloid polypeptide
Developmental Neuroscience
SDG 3 - Good Health and Well-being
description Funding: This work was supported by iNOVA4Health – UID/Multi/04462/2019, a program financially supported by Fundação para a Ciência e Tecnologia/ Ministério da Educação e Ciência, through national funds and co-funded by FEDER under the PT2020 Partnership Agreement, Funding from INTERFACE Programme, through the Innovation, Technology and Circular Economy Fund (FITEC), FCT via PTDC/BIA-MOL/31104/2017 and UID/Multi/04462/2019-SubProj iNOVA4Health C44 (to RM), PD/BD/135504/2018 (to AFR), Sociedade Portuguesa de Diabetologia for the Nuno Castelo-Branco Prize – 2016 (to RM), and ICM acknowledges FCT-MCTES Program “Concurso de Estímulo ao Emprego Científico” (CEECIND/01670/2017).
publishDate 2020
dc.date.none.fl_str_mv 2020-12-29T00:03:45Z
2021-06
2021-06-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/other
format other
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/109431
url http://hdl.handle.net/10362/109431
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1673-5374
PURE: 27075200
https://doi.org/10.4103/1673-5374.300323
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 4
application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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