Tumor de células de Leydig do ovário: caso clínico

• Main Author: Saleiro, S
• Publication Date: 2009
• Other Authors: Gonçalves, S, Marinho, C, Rebelo, T, Manarte, A, Oliveira, CF
• Format: Article
• Language: por
• Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
• Download full: http://hdl.handle.net/10400.4/728
• topic: Neoplasias do Ovário; Tumor de Células de Leydig

Leydig cell tumours account for 0.1% of all ovarian tumours and are a type of steroid cell tumour. According to the World Health Organisation they are classified in the group of sex cord stromal tumours. The clinical presentation is usually a hyperandrogenic state with signs of virilisation, but occasionally patients may exhibit a hyperestrogenic state. The tumour has a benign behaviour, with an excellent prognosis and reversion of symptoms after treatment. The authors present the case of a 61 year-old woman with signs of virilisation that started 8 months before. Abdomino-pelvic computerized tomography showed an enlarged left ovary, while blood hormone analisys revealed increased levels of testosterone, androstenedione and 17-OH progesterone. The patient was submitted to laparoscopic bilateral oophorectomy. Histological examination revealed a Leydig cell tumour of the left ovary. After surgery there was complete regression of symptoms and normalisation of sex hormone levels.