Immunomodulatory and antioxidant effects of functional aquafeeds biofortified with whole Laminaria digitata in juvenile gilthead seabream (Sparus aurata)

Bibliographic Details
Main Author: Marmelo, Isa
Publication Date: 2024
Other Authors: Dias, Marta, Grade, Ana, Pousão-Ferreira, Pedro, Diniz, Mário Sousa, Marques, António, Maulvault, Ana Luísa
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/179816
Summary: Funding Information: The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by Fundação Portuguesa para a Ciência e Tecnologia (FCT I.P.), under the framework of the project Aqua-CLIMADAPT (PTDC/CTA-AMB/0592/2021, https://doi.org/10.54499/PTDC/CTA-AMB/0592/2021) and the “Applied Molecular Biosciences Unit” (UCIBIO) which is financed by national funds from FCT/MCTES (UIDB/04378/2020), the project LA/P/0140/2020 of the Associate Laboratory Institute for Health and Bioeconomy—i4HB. IM also acknowledges FCT I.P. for the PhD grant (2020.04413.BD). Publisher Copyright: Copyright © 2024 Marmelo, Dias, Grade, Pousão-Ferreira, Diniz, Marques and Maulvault.
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spelling Immunomodulatory and antioxidant effects of functional aquafeeds biofortified with whole Laminaria digitata in juvenile gilthead seabream (Sparus aurata)animal welfareantioxidant responsesaquaculturefunctional feedsimmune responsesseaweedsOceanographyGlobal and Planetary ChangeAquatic ScienceWater Science and TechnologyEnvironmental Science (miscellaneous)Ocean EngineeringSDG 13 - Climate ActionFunding Information: The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by Fundação Portuguesa para a Ciência e Tecnologia (FCT I.P.), under the framework of the project Aqua-CLIMADAPT (PTDC/CTA-AMB/0592/2021, https://doi.org/10.54499/PTDC/CTA-AMB/0592/2021) and the “Applied Molecular Biosciences Unit” (UCIBIO) which is financed by national funds from FCT/MCTES (UIDB/04378/2020), the project LA/P/0140/2020 of the Associate Laboratory Institute for Health and Bioeconomy—i4HB. IM also acknowledges FCT I.P. for the PhD grant (2020.04413.BD). Publisher Copyright: Copyright © 2024 Marmelo, Dias, Grade, Pousão-Ferreira, Diniz, Marques and Maulvault.The increasing demand for healthy aquatic products has contributed to the rapid growth of aquaculture. Despite the many progresses, over the years, in aquaculture production, animal welfare and reduction of the stress induced by captivity remain a challenge in this sector, and overcoming it is fundamental to improve animal growth performance and resilience to environmental threats (e.g., disease outbreaks and/or climate change impacts). To address this challenge, aquafeeds biofortified with natural ingredients with functional properties, such as macroalgae, have emerged as a promising strategy to enhance fish immunity. The present study aimed at evaluating the potential of Laminaria digitata to improve juvenile gilthead seabream (Sparus aurata) physiological status and resilience, through the modulation of immunomodulatory and antioxidant responses. To explore this hypothesis, four independent treatments were carried out in which fish were fed with different experimental aquafeeds: control feed and biofortified feeds with 1.5%, 3% and 6% of whole L. digitata (incorporated as a dried and powdered ingredient). Fish (n=9) were collected from each treatment upon 30 and 60 days of biofortification in order to assess animal growth and condition indexes, haematological parameters, innate humoral parameters (antiprotease (AP) activity, peroxidase (POD) activity and immunoglobulin M (IgM)) and oxidative stress biomarkers (lipid peroxidation (LPO), catalase (CAT) activity, glutathione S-transferase (GST) activity, superoxide dismutase (SOD) activity and total antioxidant capacity (T-AOC)). Significant differences (α = 0.05) between treatments in biomarker responses were tested through a nested-design ANOVA, followed by Tukey HSD multiple comparisons. Pearson correlations between the different endpoints were also explored. Results indicate that a dietary inclusion of 1.5% L. digitata is the most effective biofortification dose, significantly improving antioxidant responses of S. aurata, by increasing levels of CAT, GST and T-AOC, along with the reduction in LPO levels. Additionally, the inclusion of 1.5% L. digitata enhances immunity by increasing the levels of IgM and POD, while maintaining the growth performance and condition indices of the fish. These findings underscore the potential utilization of L. digitata as a functional feed ingredient in aquaculture with relevant immune and antioxidant attributes.UCIBIO - Applied Molecular Biosciences UnitFaculdade de Ciências e Tecnologia (FCT)RUNMarmelo, IsaDias, MartaGrade, AnaPousão-Ferreira, PedroDiniz, Mário SousaMarques, AntónioMaulvault, Ana Luísa2025-02-25T22:23:19Z2024-01-302024-01-30T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article16application/pdfhttp://hdl.handle.net/10362/179816eng2296-7745PURE: 106509293https://doi.org/10.3389/fmars.2024.1325244info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-03T01:39:12Zoai:run.unl.pt:10362/179816Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T00:07:03.484334Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Immunomodulatory and antioxidant effects of functional aquafeeds biofortified with whole Laminaria digitata in juvenile gilthead seabream (Sparus aurata)
title Immunomodulatory and antioxidant effects of functional aquafeeds biofortified with whole Laminaria digitata in juvenile gilthead seabream (Sparus aurata)
spellingShingle Immunomodulatory and antioxidant effects of functional aquafeeds biofortified with whole Laminaria digitata in juvenile gilthead seabream (Sparus aurata)
Marmelo, Isa
animal welfare
antioxidant responses
aquaculture
functional feeds
immune responses
seaweeds
Oceanography
Global and Planetary Change
Aquatic Science
Water Science and Technology
Environmental Science (miscellaneous)
Ocean Engineering
SDG 13 - Climate Action
title_short Immunomodulatory and antioxidant effects of functional aquafeeds biofortified with whole Laminaria digitata in juvenile gilthead seabream (Sparus aurata)
title_full Immunomodulatory and antioxidant effects of functional aquafeeds biofortified with whole Laminaria digitata in juvenile gilthead seabream (Sparus aurata)
title_fullStr Immunomodulatory and antioxidant effects of functional aquafeeds biofortified with whole Laminaria digitata in juvenile gilthead seabream (Sparus aurata)
title_full_unstemmed Immunomodulatory and antioxidant effects of functional aquafeeds biofortified with whole Laminaria digitata in juvenile gilthead seabream (Sparus aurata)
title_sort Immunomodulatory and antioxidant effects of functional aquafeeds biofortified with whole Laminaria digitata in juvenile gilthead seabream (Sparus aurata)
author Marmelo, Isa
author_facet Marmelo, Isa
Dias, Marta
Grade, Ana
Pousão-Ferreira, Pedro
Diniz, Mário Sousa
Marques, António
Maulvault, Ana Luísa
author_role author
author2 Dias, Marta
Grade, Ana
Pousão-Ferreira, Pedro
Diniz, Mário Sousa
Marques, António
Maulvault, Ana Luísa
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv UCIBIO - Applied Molecular Biosciences Unit
Faculdade de Ciências e Tecnologia (FCT)
RUN
dc.contributor.author.fl_str_mv Marmelo, Isa
Dias, Marta
Grade, Ana
Pousão-Ferreira, Pedro
Diniz, Mário Sousa
Marques, António
Maulvault, Ana Luísa
dc.subject.por.fl_str_mv animal welfare
antioxidant responses
aquaculture
functional feeds
immune responses
seaweeds
Oceanography
Global and Planetary Change
Aquatic Science
Water Science and Technology
Environmental Science (miscellaneous)
Ocean Engineering
SDG 13 - Climate Action
topic animal welfare
antioxidant responses
aquaculture
functional feeds
immune responses
seaweeds
Oceanography
Global and Planetary Change
Aquatic Science
Water Science and Technology
Environmental Science (miscellaneous)
Ocean Engineering
SDG 13 - Climate Action
description Funding Information: The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by Fundação Portuguesa para a Ciência e Tecnologia (FCT I.P.), under the framework of the project Aqua-CLIMADAPT (PTDC/CTA-AMB/0592/2021, https://doi.org/10.54499/PTDC/CTA-AMB/0592/2021) and the “Applied Molecular Biosciences Unit” (UCIBIO) which is financed by national funds from FCT/MCTES (UIDB/04378/2020), the project LA/P/0140/2020 of the Associate Laboratory Institute for Health and Bioeconomy—i4HB. IM also acknowledges FCT I.P. for the PhD grant (2020.04413.BD). Publisher Copyright: Copyright © 2024 Marmelo, Dias, Grade, Pousão-Ferreira, Diniz, Marques and Maulvault.
publishDate 2024
dc.date.none.fl_str_mv 2024-01-30
2024-01-30T00:00:00Z
2025-02-25T22:23:19Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/179816
url http://hdl.handle.net/10362/179816
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2296-7745
PURE: 106509293
https://doi.org/10.3389/fmars.2024.1325244
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 16
application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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