Wasting, Stunting, and Anemia in Angolan Children after Deworming with Albendazole or a Test-and-Treat Approach for Intestinal Parasites

Bibliographic Details
Main Author: Gasparinho, Carolina
Publication Date: 2022
Other Authors: Gonçalves, Maria Helena, Chissaque, Assucênio, Silva, Giovani L., Fortes, Filomeno, Gonçalves, Luzia
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/148019
Summary: Funding Information: Funding: This work was supported by the promoters of CISA (Camões, Institute of Cooperation and Language, Portugal; Calouste Gulbenkian Foundation (FCG); Government of Bengo Province; Angolan Ministry of Health—MINSA) and the National Malaria Control Program, Angola; the Foundation for Science and Technology (FCT, grants reference SFRH/BD/91566/2012, UIDB/00006/2020, UIDP/00006/2020, and UID/04413/2020); and the FCG (grant number 212008), Lisbon, Portugal. Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
id RCAP_33eccb4ab8208cbd132eb15ede4b54e4
oai_identifier_str oai:run.unl.pt:10362/148019
network_acronym_str RCAP
network_name_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository_id_str https://opendoar.ac.uk/repository/7160
spelling Wasting, Stunting, and Anemia in Angolan Children after Deworming with Albendazole or a Test-and-Treat Approach for Intestinal ParasitesBinary Longitudinal Models with Temporal Structure in a Four-Arm Randomized TrialanemiaAngoladewormingintestinal parasiteslongitudinalmalnutritionmild-to-severemoderate-to-severestuntingtest-and-treatwastingRA0421 Public health. Hygiene. Preventive MedicineQR MicrobiologyFood ScienceNutrition and DieteticsGastroenterologyInfectious DiseasesPediatrics, Perinatology, and Child HealthParasitologyGeneral Immunology and MicrobiologySDG 3 - Good Health and Well-beingSDG 1 - No PovertySDG 10 - Reduced InequalitiesSDG 9 - Industry, Innovation, and InfrastructureSDG 2 - Zero HungerFunding Information: Funding: This work was supported by the promoters of CISA (Camões, Institute of Cooperation and Language, Portugal; Calouste Gulbenkian Foundation (FCG); Government of Bengo Province; Angolan Ministry of Health—MINSA) and the National Malaria Control Program, Angola; the Foundation for Science and Technology (FCT, grants reference SFRH/BD/91566/2012, UIDB/00006/2020, UIDP/00006/2020, and UID/04413/2020); and the FCG (grant number 212008), Lisbon, Portugal. Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.Undernutrition, anemia, and intestinal parasitic infections are public health problems in Angola, especially in pre-school children. We analyzed binary data from a longitudinal four-arm randomized parallel trial conducted in Bengo Province, northern Angola, over the course of two years, with seven follow-up assessments to explore the effects of four interventions (deworming and a test-and-treat approach for intestinal parasites, at both the individual and household levels) on wasting and stunting, and to understand their indirect benefits for anemia, malaria, diarrhea, and vomiting. A total of 121 children with intestinal parasitic infections received baseline treatment, and were allocated to the four arms (1:1:1:1). Using continuous outcome variables of height-for-age (HAZ) and weight-for-height (WHZ) statistical approaches did not reveal a clear benefit of any particular arm (Pathogens 2021, 10, 309). Next, HAZ and WHZ were transformed into binary variables of stunting and wasting, respectively, considering their mild-to-severe (Z-score < −1) and moderate-to-severe degrees (Z-score < −2). Original clinical data (on anemia, diarrhea, vomiting, and malaria) were also analyzed. From a binary longitudinal analysis with different dependence structures, using the R package bild, fitted models revealed the potential benefit of a test-and-treat approach at the individual level for wasting compared with annual albendazole at the individual level, especially considering mild-to-severe forms (ORadj = 0.27; p = 0.007). All arms showed similar effects on stunting, compared with annual albendazole, at a 5% significance level. Time and age at baseline presented favorable effects in the percentage of stunting using both severity degrees. Results showed a decreased chance of having anemia and diarrhea over time, although with no significant differences between arms. Data from longitudinal studies are essential to study the direct and indirect effects of interventions, such as deworming, and to explore additional approaches aiming at better understanding the temporal structure of nutrition and health outcomes in children.Individual Health Care (IHC)Global Health and Tropical Medicine (GHTM)Instituto de Higiene e Medicina Tropical (IHMT)Population health, policies and services (PPS)RUNGasparinho, CarolinaGonçalves, Maria HelenaChissaque, AssucênioSilva, Giovani L.Fortes, FilomenoGonçalves, Luzia2023-01-23T22:15:53Z2022-06-012022-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/148019eng1422-8599PURE: 50841983https://doi.org/10.3390/nu14112185info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-31T01:51:00Zoai:run.unl.pt:10362/148019Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:38:49.831001Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Wasting, Stunting, and Anemia in Angolan Children after Deworming with Albendazole or a Test-and-Treat Approach for Intestinal Parasites
Binary Longitudinal Models with Temporal Structure in a Four-Arm Randomized Trial
title Wasting, Stunting, and Anemia in Angolan Children after Deworming with Albendazole or a Test-and-Treat Approach for Intestinal Parasites
spellingShingle Wasting, Stunting, and Anemia in Angolan Children after Deworming with Albendazole or a Test-and-Treat Approach for Intestinal Parasites
Gasparinho, Carolina
anemia
Angola
deworming
intestinal parasites
longitudinal
malnutrition
mild-to-severe
moderate-to-severe
stunting
test-and-treat
wasting
RA0421 Public health. Hygiene. Preventive Medicine
QR Microbiology
Food Science
Nutrition and Dietetics
Gastroenterology
Infectious Diseases
Pediatrics, Perinatology, and Child Health
Parasitology
General Immunology and Microbiology
SDG 3 - Good Health and Well-being
SDG 1 - No Poverty
SDG 10 - Reduced Inequalities
SDG 9 - Industry, Innovation, and Infrastructure
SDG 2 - Zero Hunger
title_short Wasting, Stunting, and Anemia in Angolan Children after Deworming with Albendazole or a Test-and-Treat Approach for Intestinal Parasites
title_full Wasting, Stunting, and Anemia in Angolan Children after Deworming with Albendazole or a Test-and-Treat Approach for Intestinal Parasites
title_fullStr Wasting, Stunting, and Anemia in Angolan Children after Deworming with Albendazole or a Test-and-Treat Approach for Intestinal Parasites
title_full_unstemmed Wasting, Stunting, and Anemia in Angolan Children after Deworming with Albendazole or a Test-and-Treat Approach for Intestinal Parasites
title_sort Wasting, Stunting, and Anemia in Angolan Children after Deworming with Albendazole or a Test-and-Treat Approach for Intestinal Parasites
author Gasparinho, Carolina
author_facet Gasparinho, Carolina
Gonçalves, Maria Helena
Chissaque, Assucênio
Silva, Giovani L.
Fortes, Filomeno
Gonçalves, Luzia
author_role author
author2 Gonçalves, Maria Helena
Chissaque, Assucênio
Silva, Giovani L.
Fortes, Filomeno
Gonçalves, Luzia
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Individual Health Care (IHC)
Global Health and Tropical Medicine (GHTM)
Instituto de Higiene e Medicina Tropical (IHMT)
Population health, policies and services (PPS)
RUN
dc.contributor.author.fl_str_mv Gasparinho, Carolina
Gonçalves, Maria Helena
Chissaque, Assucênio
Silva, Giovani L.
Fortes, Filomeno
Gonçalves, Luzia
dc.subject.por.fl_str_mv anemia
Angola
deworming
intestinal parasites
longitudinal
malnutrition
mild-to-severe
moderate-to-severe
stunting
test-and-treat
wasting
RA0421 Public health. Hygiene. Preventive Medicine
QR Microbiology
Food Science
Nutrition and Dietetics
Gastroenterology
Infectious Diseases
Pediatrics, Perinatology, and Child Health
Parasitology
General Immunology and Microbiology
SDG 3 - Good Health and Well-being
SDG 1 - No Poverty
SDG 10 - Reduced Inequalities
SDG 9 - Industry, Innovation, and Infrastructure
SDG 2 - Zero Hunger
topic anemia
Angola
deworming
intestinal parasites
longitudinal
malnutrition
mild-to-severe
moderate-to-severe
stunting
test-and-treat
wasting
RA0421 Public health. Hygiene. Preventive Medicine
QR Microbiology
Food Science
Nutrition and Dietetics
Gastroenterology
Infectious Diseases
Pediatrics, Perinatology, and Child Health
Parasitology
General Immunology and Microbiology
SDG 3 - Good Health and Well-being
SDG 1 - No Poverty
SDG 10 - Reduced Inequalities
SDG 9 - Industry, Innovation, and Infrastructure
SDG 2 - Zero Hunger
description Funding Information: Funding: This work was supported by the promoters of CISA (Camões, Institute of Cooperation and Language, Portugal; Calouste Gulbenkian Foundation (FCG); Government of Bengo Province; Angolan Ministry of Health—MINSA) and the National Malaria Control Program, Angola; the Foundation for Science and Technology (FCT, grants reference SFRH/BD/91566/2012, UIDB/00006/2020, UIDP/00006/2020, and UID/04413/2020); and the FCG (grant number 212008), Lisbon, Portugal. Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
publishDate 2022
dc.date.none.fl_str_mv 2022-06-01
2022-06-01T00:00:00Z
2023-01-23T22:15:53Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/148019
url http://hdl.handle.net/10362/148019
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1422-8599
PURE: 50841983
https://doi.org/10.3390/nu14112185
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833596859658010624

Similar Items