Chemical synthesis of new histone deacetylase inhibitors and their evaluation as anticancer agents

Bibliographic Details
Main Author: Diana O. Silva
Publication Date: 2016
Format: Master thesis
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/65531
Summary: "Epigenetics and its key role in gene expression have become increasingly important in cancer research. Histone proteins play an important role in gene expression control through modifications like acetylation, phosphorylation and methylation. Histone deacetylases (HDAC) can regulate expression levels via acetylation of lysine residues of histone proteins.(...)"
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network_acronym_str RCAP
network_name_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository_id_str https://opendoar.ac.uk/repository/7160
spelling Chemical synthesis of new histone deacetylase inhibitors and their evaluation as anticancer agentsHDACiChemical SynthesisBiochemistry"Epigenetics and its key role in gene expression have become increasingly important in cancer research. Histone proteins play an important role in gene expression control through modifications like acetylation, phosphorylation and methylation. Histone deacetylases (HDAC) can regulate expression levels via acetylation of lysine residues of histone proteins.(...)"Ventura, RitaRUNDiana O. Silva2019-04-04T15:36:44Z20162016-112016-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://hdl.handle.net/10362/65531enginfo:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T17:38:31Zoai:run.unl.pt:10362/65531Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:09:39.686665Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Chemical synthesis of new histone deacetylase inhibitors and their evaluation as anticancer agents
title Chemical synthesis of new histone deacetylase inhibitors and their evaluation as anticancer agents
spellingShingle Chemical synthesis of new histone deacetylase inhibitors and their evaluation as anticancer agents
Diana O. Silva
HDACi
Chemical Synthesis
Biochemistry
title_short Chemical synthesis of new histone deacetylase inhibitors and their evaluation as anticancer agents
title_full Chemical synthesis of new histone deacetylase inhibitors and their evaluation as anticancer agents
title_fullStr Chemical synthesis of new histone deacetylase inhibitors and their evaluation as anticancer agents
title_full_unstemmed Chemical synthesis of new histone deacetylase inhibitors and their evaluation as anticancer agents
title_sort Chemical synthesis of new histone deacetylase inhibitors and their evaluation as anticancer agents
author Diana O. Silva
author_facet Diana O. Silva
author_role author
dc.contributor.none.fl_str_mv Ventura, Rita
RUN
dc.contributor.author.fl_str_mv Diana O. Silva
dc.subject.por.fl_str_mv HDACi
Chemical Synthesis
Biochemistry
topic HDACi
Chemical Synthesis
Biochemistry
description "Epigenetics and its key role in gene expression have become increasingly important in cancer research. Histone proteins play an important role in gene expression control through modifications like acetylation, phosphorylation and methylation. Histone deacetylases (HDAC) can regulate expression levels via acetylation of lysine residues of histone proteins.(...)"
publishDate 2016
dc.date.none.fl_str_mv 2016
2016-11
2016-01-01T00:00:00Z
2019-04-04T15:36:44Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/65531
url http://hdl.handle.net/10362/65531
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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