Montelukast and Neuropsychiatric Events in Children: What is the Evidence?

Bibliographic Details
Main Author: Lima, Raquel
Publication Date: 2024
Other Authors: Sá Moreira , Mafalda, Rocha, Leonor, Nuno Carneiro, João, Azevedo, José Miguel
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: https://doi.org/10.29315/gm.v11i4.774
Summary: Childhood asthma is a prevalent chronic illness, and the medication montelukast is frequently used as treatment. However, this drug has been linked to neuropsychiatric events that have potentially fatal outcomes. The objective of this review paper was to evaluate the available evidence on this association between montelukast and neuropsychiatric events in children. From an analysis of 17 articles and 1 clinical guidance standard identified by a bibliographic search method, only 5 fulfilled the previously defined inclusion criteria. These selected studies provide support for the existence of possible occurrences of montelukast-induced neuropsychiatric symptoms among asthmatic pediatric patients administered with the medication. Therefore, healthcare providers need to be informed about these risks while making prescribing decisions for young patients who are taking montelukast or undergoing follow-up care subsequently. More multicenter studies are needed, with robust samples, longer follow-up period and well-defined methodology, to clarify the association of montelukast with neuropsychiatric events in children.
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spelling Montelukast and Neuropsychiatric Events in Children: What is the Evidence?Montelucaste e Eventos Neuropsiquiátricos em Idade Pediátrica: Qual a Evidência?Anti-Asthmatic Agents/adverse effectsChildMental Disorders/chemically inducedMontelukast/ adverse effectsNervous System Diseases/chemically inducedAntiasmáticos/efeitos adversosCriançaDoenças do Sistema Nervoso/induzidas quimicamenteMontelucaste/efeitos adversosPerturbações Mentais/induzidas quimicamenteChildhood asthma is a prevalent chronic illness, and the medication montelukast is frequently used as treatment. However, this drug has been linked to neuropsychiatric events that have potentially fatal outcomes. The objective of this review paper was to evaluate the available evidence on this association between montelukast and neuropsychiatric events in children. From an analysis of 17 articles and 1 clinical guidance standard identified by a bibliographic search method, only 5 fulfilled the previously defined inclusion criteria. These selected studies provide support for the existence of possible occurrences of montelukast-induced neuropsychiatric symptoms among asthmatic pediatric patients administered with the medication. Therefore, healthcare providers need to be informed about these risks while making prescribing decisions for young patients who are taking montelukast or undergoing follow-up care subsequently. More multicenter studies are needed, with robust samples, longer follow-up period and well-defined methodology, to clarify the association of montelukast with neuropsychiatric events in children.A asma é uma doença crónica muito frequente na infância, sendo o montelucaste utilizado no seu tratamento. Este fármaco tem sido associado a alterações neuropsiquiátricas potencialmente letais. O objetivo desta revisão é avaliar a evidência acerca dos seus efeitos neuropsiquiátricos em idade pediátrica. Da pesquisa bibliográfica resultaram 17 artigos e uma norma de orientação clínica, tendo 5 cumprido os critérios de inclusão previamente definidos. Após análise dos artigos considera-se que existe evidência da ocorrência de eventos neuropsiquiátricos em crianças asmáticas medicadas com montelucaste. Os clínicos devem estar informados acerca desta associação, para realizarem prescrições conscientes e estarem alerta durante o seguimento destas crianças. São necessários mais estudos, multicêntricos, com amostras mais robustas, com um período de acompanhamento mais prolongado e com metodologia bem definida, que clarifiquem a associação de montelucaste a eventos neuropsiquiátricos em idade pediátrica.CUF Academic Center2024-12-27info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://doi.org/10.29315/gm.v11i4.774https://doi.org/10.29315/gm.v11i4.774Gazeta Médica; NUMBER 4 · VOLUME 11 · OCTOBER/DECEMBER 2024; 301-306Gazeta Médica; NÚMERO 4 · VOLUME 11 · OUTUBRO/DEZEMBRO 2024; 301-3062184-06282183-813510.29315/gm.v11i4reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAPenghttps://www.gazetamedica.pt/index.php/gazeta/article/view/774https://www.gazetamedica.pt/index.php/gazeta/article/view/774/452Copyright (c) 2023 Gazeta Médicainfo:eu-repo/semantics/openAccessLima, RaquelSá Moreira , MafaldaRocha, LeonorNuno Carneiro, JoãoAzevedo, José Miguel2024-12-28T04:45:29Zoai:ojs.pkp.sfu.ca:article/774Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T11:14:47.335499Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Montelukast and Neuropsychiatric Events in Children: What is the Evidence?
Montelucaste e Eventos Neuropsiquiátricos em Idade Pediátrica: Qual a Evidência?
title Montelukast and Neuropsychiatric Events in Children: What is the Evidence?
spellingShingle Montelukast and Neuropsychiatric Events in Children: What is the Evidence?
Lima, Raquel
Anti-Asthmatic Agents/adverse effects
Child
Mental Disorders/chemically induced
Montelukast/ adverse effects
Nervous System Diseases/chemically induced
Antiasmáticos/efeitos adversos
Criança
Doenças do Sistema Nervoso/induzidas quimicamente
Montelucaste/efeitos adversos
Perturbações Mentais/induzidas quimicamente
title_short Montelukast and Neuropsychiatric Events in Children: What is the Evidence?
title_full Montelukast and Neuropsychiatric Events in Children: What is the Evidence?
title_fullStr Montelukast and Neuropsychiatric Events in Children: What is the Evidence?
title_full_unstemmed Montelukast and Neuropsychiatric Events in Children: What is the Evidence?
title_sort Montelukast and Neuropsychiatric Events in Children: What is the Evidence?
author Lima, Raquel
author_facet Lima, Raquel
Sá Moreira , Mafalda
Rocha, Leonor
Nuno Carneiro, João
Azevedo, José Miguel
author_role author
author2 Sá Moreira , Mafalda
Rocha, Leonor
Nuno Carneiro, João
Azevedo, José Miguel
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Lima, Raquel
Sá Moreira , Mafalda
Rocha, Leonor
Nuno Carneiro, João
Azevedo, José Miguel
dc.subject.por.fl_str_mv Anti-Asthmatic Agents/adverse effects
Child
Mental Disorders/chemically induced
Montelukast/ adverse effects
Nervous System Diseases/chemically induced
Antiasmáticos/efeitos adversos
Criança
Doenças do Sistema Nervoso/induzidas quimicamente
Montelucaste/efeitos adversos
Perturbações Mentais/induzidas quimicamente
topic Anti-Asthmatic Agents/adverse effects
Child
Mental Disorders/chemically induced
Montelukast/ adverse effects
Nervous System Diseases/chemically induced
Antiasmáticos/efeitos adversos
Criança
Doenças do Sistema Nervoso/induzidas quimicamente
Montelucaste/efeitos adversos
Perturbações Mentais/induzidas quimicamente
description Childhood asthma is a prevalent chronic illness, and the medication montelukast is frequently used as treatment. However, this drug has been linked to neuropsychiatric events that have potentially fatal outcomes. The objective of this review paper was to evaluate the available evidence on this association between montelukast and neuropsychiatric events in children. From an analysis of 17 articles and 1 clinical guidance standard identified by a bibliographic search method, only 5 fulfilled the previously defined inclusion criteria. These selected studies provide support for the existence of possible occurrences of montelukast-induced neuropsychiatric symptoms among asthmatic pediatric patients administered with the medication. Therefore, healthcare providers need to be informed about these risks while making prescribing decisions for young patients who are taking montelukast or undergoing follow-up care subsequently. More multicenter studies are needed, with robust samples, longer follow-up period and well-defined methodology, to clarify the association of montelukast with neuropsychiatric events in children.
publishDate 2024
dc.date.none.fl_str_mv 2024-12-27
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://doi.org/10.29315/gm.v11i4.774
https://doi.org/10.29315/gm.v11i4.774
url https://doi.org/10.29315/gm.v11i4.774
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.gazetamedica.pt/index.php/gazeta/article/view/774
https://www.gazetamedica.pt/index.php/gazeta/article/view/774/452
dc.rights.driver.fl_str_mv Copyright (c) 2023 Gazeta Médica
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2023 Gazeta Médica
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv CUF Academic Center
publisher.none.fl_str_mv CUF Academic Center
dc.source.none.fl_str_mv Gazeta Médica; NUMBER 4 · VOLUME 11 · OCTOBER/DECEMBER 2024; 301-306
Gazeta Médica; NÚMERO 4 · VOLUME 11 · OUTUBRO/DEZEMBRO 2024; 301-306
2184-0628
2183-8135
10.29315/gm.v11i4
reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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