Cancer Screening and Cancer Treatment in Kidney Transplant Recipients

Bibliographic Details
Main Author: Bigotte Vieira, Miguel
Publication Date: 2024
Other Authors: Arai, Hiroyuki, Nicolau, Carla Adriana Ferreira, Murakami, Naoka
Format: Other
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/175182
Summary: Publisher Copyright: Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Society of Nephrology.
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network_name_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
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spelling Cancer Screening and Cancer Treatment in Kidney Transplant RecipientsMedicine(all)SDG 3 - Good Health and Well-beingPublisher Copyright: Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Society of Nephrology.As the population ages and post-transplant survival improves, pretransplant and post-transplant malignancy are becoming increasingly common. In addition, rapid advances in cancer therapies and improving outcomes prompt us to rethink pretransplant cancer-free wait time and screening strategies. Although kidney transplant recipients (KTRs) are at higher risk of developing cancer, epidemiological data on how to best screen and treat cancers in KTRs are incomplete. Thus, current recommendations are still largely on the basis of studies in the general population, and their validity in KTRs is uncertain. Kidney transplant candidates without prior cancer should be evaluated for latent malignancies even in the absence of symptoms. Conversely, individuals with a history of malignancy require thorough monitoring to detect potential recurrences or de novo malignancies. When treating KTRs with cancer, reducing immunosuppression can enhance antitumor immunity, yet this also increases the risk of graft rejection. Optimal treatment and immunosuppression management remains undefined. As the emergence of novel cancer therapies adds complexity to this challenge, individualized risk-benefit assessment is crucial. In this review, we discuss up-to-date data on pretransplant screening and cancer-free wait time, as well as post-transplant cancer screening, prevention strategies, and treatment, including novel therapies such as immune checkpoint inhibitors and chimeric antigen receptor T-cell therapies.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNBigotte Vieira, MiguelArai, HiroyukiNicolau, Carla Adriana FerreiraMurakami, Naoka2024-11-13T23:52:25Z2024-10-012024-10-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/other15application/pdfhttp://hdl.handle.net/10362/175182eng2641-7650PURE: 102888124https://doi.org/10.34067/KID.0000000000000545info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-02-10T01:36:54Zoai:run.unl.pt:10362/175182Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T19:14:11.747033Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Cancer Screening and Cancer Treatment in Kidney Transplant Recipients
title Cancer Screening and Cancer Treatment in Kidney Transplant Recipients
spellingShingle Cancer Screening and Cancer Treatment in Kidney Transplant Recipients
Bigotte Vieira, Miguel
Medicine(all)
SDG 3 - Good Health and Well-being
title_short Cancer Screening and Cancer Treatment in Kidney Transplant Recipients
title_full Cancer Screening and Cancer Treatment in Kidney Transplant Recipients
title_fullStr Cancer Screening and Cancer Treatment in Kidney Transplant Recipients
title_full_unstemmed Cancer Screening and Cancer Treatment in Kidney Transplant Recipients
title_sort Cancer Screening and Cancer Treatment in Kidney Transplant Recipients
author Bigotte Vieira, Miguel
author_facet Bigotte Vieira, Miguel
Arai, Hiroyuki
Nicolau, Carla Adriana Ferreira
Murakami, Naoka
author_role author
author2 Arai, Hiroyuki
Nicolau, Carla Adriana Ferreira
Murakami, Naoka
author2_role author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Bigotte Vieira, Miguel
Arai, Hiroyuki
Nicolau, Carla Adriana Ferreira
Murakami, Naoka
dc.subject.por.fl_str_mv Medicine(all)
SDG 3 - Good Health and Well-being
topic Medicine(all)
SDG 3 - Good Health and Well-being
description Publisher Copyright: Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Society of Nephrology.
publishDate 2024
dc.date.none.fl_str_mv 2024-11-13T23:52:25Z
2024-10-01
2024-10-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/other
format other
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/175182
url http://hdl.handle.net/10362/175182
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2641-7650
PURE: 102888124
https://doi.org/10.34067/KID.0000000000000545
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 15
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dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
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reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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