Bioinspired soft nanovesicles for site-selective cancer imaging and targeted therapies

Bibliographic Details
Main Author: Prasad, Rajendra
Publication Date: 2022
Other Authors: Conde, João
Format: Other
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/154201
Summary: Funding Information: European Research Council, ERC Starting Grant, Grant/Award Number: ERC‐StG‐2019‐848325 Funding information Funding Information: This work is supported by the European Research Council, ERC Starting Grant ‐ ERC‐StG‐2019‐848325. The authors would like to thank Dr. N. K. Jain, Dr. S. Meena, and Dr. Gorain for glancing at this article. We would like to dedicate this article to the memory of late Prof. Sanjiv Sam Gambhir, a molecular imaging and early cancer detection scientist. We have cited all reproduced images and figures in this review. Publisher Copyright: © 2022 Wiley Periodicals LLC.
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spelling Bioinspired soft nanovesicles for site-selective cancer imaging and targeted therapiesnanoCellsnanoTheranosticsnanovesiclestargeted therapyBioengineeringMedicine (miscellaneous)Biomedical EngineeringSDG 3 - Good Health and Well-beingFunding Information: European Research Council, ERC Starting Grant, Grant/Award Number: ERC‐StG‐2019‐848325 Funding information Funding Information: This work is supported by the European Research Council, ERC Starting Grant ‐ ERC‐StG‐2019‐848325. The authors would like to thank Dr. N. K. Jain, Dr. S. Meena, and Dr. Gorain for glancing at this article. We would like to dedicate this article to the memory of late Prof. Sanjiv Sam Gambhir, a molecular imaging and early cancer detection scientist. We have cited all reproduced images and figures in this review. Publisher Copyright: © 2022 Wiley Periodicals LLC.Cell-to-cell communication within the heterogeneous solid tumor environment plays a significant role in the uncontrolled metastasis of cancer. To inhibit the metastasis and growth of cancer cells, various chemically designed and biologically derived nanosized biomaterials have been applied for targeted cancer therapeutics applications. Over the years, bioinspired soft nanovesicles have gained tremendous attention for targeted cancer therapeutics due to their easy binding with tumor microenvironment, natural targeting ability, bio-responsive nature, better biocompatibility, high cargo capacity for multiple therapeutics agents, and long circulation time. These cell-derived nanovesicles guard their loaded cargo molecules from immune clearance and make them site-selective to cancer cells due to their natural binding and delivery abilities. Furthermore, bioinspired soft nanovesicles prevent cell-to-cell communication and secretion of cancer cell markers by delivering the therapeutics agents predominantly. Cell-derived vesicles, namely, exosomes, extracellular vesicles, and so forth have been recognized as versatile carriers for therapeutic biomolecules. However, low product yield, poor reproducibility, and uncontrolled particle size distribution have remained as major challenges of these soft nanovesicles. Furthermore, the surface biomarkers and molecular contents of these vesicles change with respect to the stage of disease and types. Here in this review, we have discussed numerous examples of bioinspired soft vesicles for targeted imaging and cancer therapeutic applications with their advantages and limitations. Importance of bioengineered soft nanovesicles for localized therapies with their clinical relevance has also been addressed in this article. Overall, cell-derived nanovesicles could be considered as clinically relevant platforms for cancer therapeutics. This article is categorized under: Biology-Inspired Nanomaterials > Nucleic Acid-Based Structures Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centre for Toxicogenomics and Human Health (ToxOmics)RUNPrasad, RajendraConde, João2023-06-20T22:19:34Z2022-072022-07-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/otherapplication/pdfhttp://hdl.handle.net/10362/154201eng1939-5116PURE: 42980985https://doi.org/10.1002/wnan.1792info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-05-26T01:40:50Zoai:run.unl.pt:10362/154201Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:42:34.672092Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Bioinspired soft nanovesicles for site-selective cancer imaging and targeted therapies
title Bioinspired soft nanovesicles for site-selective cancer imaging and targeted therapies
spellingShingle Bioinspired soft nanovesicles for site-selective cancer imaging and targeted therapies
Prasad, Rajendra
nanoCells
nanoTheranostics
nanovesicles
targeted therapy
Bioengineering
Medicine (miscellaneous)
Biomedical Engineering
SDG 3 - Good Health and Well-being
title_short Bioinspired soft nanovesicles for site-selective cancer imaging and targeted therapies
title_full Bioinspired soft nanovesicles for site-selective cancer imaging and targeted therapies
title_fullStr Bioinspired soft nanovesicles for site-selective cancer imaging and targeted therapies
title_full_unstemmed Bioinspired soft nanovesicles for site-selective cancer imaging and targeted therapies
title_sort Bioinspired soft nanovesicles for site-selective cancer imaging and targeted therapies
author Prasad, Rajendra
author_facet Prasad, Rajendra
Conde, João
author_role author
author2 Conde, João
author2_role author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Centre for Toxicogenomics and Human Health (ToxOmics)
RUN
dc.contributor.author.fl_str_mv Prasad, Rajendra
Conde, João
dc.subject.por.fl_str_mv nanoCells
nanoTheranostics
nanovesicles
targeted therapy
Bioengineering
Medicine (miscellaneous)
Biomedical Engineering
SDG 3 - Good Health and Well-being
topic nanoCells
nanoTheranostics
nanovesicles
targeted therapy
Bioengineering
Medicine (miscellaneous)
Biomedical Engineering
SDG 3 - Good Health and Well-being
description Funding Information: European Research Council, ERC Starting Grant, Grant/Award Number: ERC‐StG‐2019‐848325 Funding information Funding Information: This work is supported by the European Research Council, ERC Starting Grant ‐ ERC‐StG‐2019‐848325. The authors would like to thank Dr. N. K. Jain, Dr. S. Meena, and Dr. Gorain for glancing at this article. We would like to dedicate this article to the memory of late Prof. Sanjiv Sam Gambhir, a molecular imaging and early cancer detection scientist. We have cited all reproduced images and figures in this review. Publisher Copyright: © 2022 Wiley Periodicals LLC.
publishDate 2022
dc.date.none.fl_str_mv 2022-07
2022-07-01T00:00:00Z
2023-06-20T22:19:34Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/other
format other
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/154201
url http://hdl.handle.net/10362/154201
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1939-5116
PURE: 42980985
https://doi.org/10.1002/wnan.1792
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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