Optimizing patient selection for cardiac resynchronization therapy: the role of cardiopulmonary exercise testing

Bibliographic Details
Main Author: Pinto, Maria Rita da Silva Alexandre
Publication Date: 2012
Format: Master thesis
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10400.5/5473
Summary: Mestrado em Exercício e Saúde
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network_name_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
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spelling Optimizing patient selection for cardiac resynchronization therapy: the role of cardiopulmonary exercise testingCardiac resynchronization therapyCardiopulmonary exercise testingExercise capacityHeart failureHeart rate responseOxigen uptakePrognosisRespondersSlope of the ventilatory responseVentilatory thresholdMestrado em Exercício e SaúdeBackground: Cardiac resynchronization therapy (CRT) is an established treatment modality for moderate to severe heart failure (HF) but 30–40% of patients treated with CRT do not experience clinical improvement. Purpose: the aim of this study was to identify predictors of response to CRT, in two different definitions of responders, by using the cardiopulmonary exercise testing (CPET) before CRT implantation. In definition A, responders were defined as ≥15% improvement in left ventricular ejection fraction (LVEF); in definition B combined parameters were defined as ≥5% improvement in LVEF and ≤1 level NYHA classification. Methods: this is a prospective observational study of 15 HF patients undergoing CRT. Clinical CPET and echocardiography assessment using standard methods were performed at baseline and 5 months. Results: the number of patients classified as responders in definition A was 9 (60%) and 6 (40%) as non-responders; the number of responders in definition B was 11 (73.3%) and 4 (26.7%) as non-responders at 5 months after CRT. The responders according to definition A did not present any statistically significant difference. According to definition B, the heart rate (HR) response during CPET was higher in non-responders: HR peak (157±13bpm vs. 118±18bpm, p<0.05) and HR recovery at minute 3 (54±13bpm vs. 31 ± 14bpm, p<0.05). Overall, the responders were older (68±9years vs. 55±9years, p<0.05). Conclusions: baseline measurements of CPET may be utilized to identify patients that benefit from CRT. The use of combined criteria is a better predictor than LVEF alone.Rodrigues, Maria Helena Santa-Clara PomboRepositório da Universidade de LisboaPinto, Maria Rita da Silva Alexandre2013-04-23T14:37:03Z20122012-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://hdl.handle.net/10400.5/5473TID:101461640engPinto, Maria Rita (2012) - Optimizing patient selection for cardiac resynchronization therapy: the role of cardiopulmonary exercise testing.(2012) Dissertação de Mestrado. Universidade Técnica de Lisboa. Faculdade de Motricidade Humanainfo:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-17T15:49:37Zoai:repositorio.ulisboa.pt:10400.5/5473Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T03:55:07.380593Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Optimizing patient selection for cardiac resynchronization therapy: the role of cardiopulmonary exercise testing
title Optimizing patient selection for cardiac resynchronization therapy: the role of cardiopulmonary exercise testing
spellingShingle Optimizing patient selection for cardiac resynchronization therapy: the role of cardiopulmonary exercise testing
Pinto, Maria Rita da Silva Alexandre
Cardiac resynchronization therapy
Cardiopulmonary exercise testing
Exercise capacity
Heart failure
Heart rate response
Oxigen uptake
Prognosis
Responders
Slope of the ventilatory response
Ventilatory threshold
title_short Optimizing patient selection for cardiac resynchronization therapy: the role of cardiopulmonary exercise testing
title_full Optimizing patient selection for cardiac resynchronization therapy: the role of cardiopulmonary exercise testing
title_fullStr Optimizing patient selection for cardiac resynchronization therapy: the role of cardiopulmonary exercise testing
title_full_unstemmed Optimizing patient selection for cardiac resynchronization therapy: the role of cardiopulmonary exercise testing
title_sort Optimizing patient selection for cardiac resynchronization therapy: the role of cardiopulmonary exercise testing
author Pinto, Maria Rita da Silva Alexandre
author_facet Pinto, Maria Rita da Silva Alexandre
author_role author
dc.contributor.none.fl_str_mv Rodrigues, Maria Helena Santa-Clara Pombo
Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Pinto, Maria Rita da Silva Alexandre
dc.subject.por.fl_str_mv Cardiac resynchronization therapy
Cardiopulmonary exercise testing
Exercise capacity
Heart failure
Heart rate response
Oxigen uptake
Prognosis
Responders
Slope of the ventilatory response
Ventilatory threshold
topic Cardiac resynchronization therapy
Cardiopulmonary exercise testing
Exercise capacity
Heart failure
Heart rate response
Oxigen uptake
Prognosis
Responders
Slope of the ventilatory response
Ventilatory threshold
description Mestrado em Exercício e Saúde
publishDate 2012
dc.date.none.fl_str_mv 2012
2012-01-01T00:00:00Z
2013-04-23T14:37:03Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.5/5473
TID:101461640
url http://hdl.handle.net/10400.5/5473
identifier_str_mv TID:101461640
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Pinto, Maria Rita (2012) - Optimizing patient selection for cardiac resynchronization therapy: the role of cardiopulmonary exercise testing.(2012) Dissertação de Mestrado. Universidade Técnica de Lisboa. Faculdade de Motricidade Humana
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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