Complete blood count parameters as biomarkers of retinopathy of prematurity: a Portuguese multicenter study

Detalhes bibliográficos
Autor(a) principal: Fevereiro-Martins, Mariza
Data de Publicação: 2023
Outros Autores: Santos, Ana Carolina, Marques-Neves, Carlos, Guimarães, Hercília, Bicho, Manuel, Afonso, Conceição, Ferreira, Joana, Santo, Rita Espírito, Jorge Teixeira, Filipa, Rosa, Rita, Carneiro, Cristina Vaz, Ferreira, Marta, Matos, Teresa, Neiva, Luísa, Pereira, Sandra, Aires, Sofia, Parreira, Ricardo, Melnik, Zuzana, Faria, João, Teixeira, Joana, Barros, Pedro, Almeida, Juliana, Malheiro, Bruna, Rodrigues, Patrícia Cunha, Albuquerque, Luís, Freitas, Alice, Kotchekova, Nadezda, Freitas, Rui, Silveira, Ana Cristina, Ferreira, Ana, Morais, Benvinda, Teixeira, Susana, Mota, Mafalda, Guerra, Maria, Coimbra, Lúcia, Gigante, João, Ferreira, Muriel, Lapa, Patrícia, Monteiro, Madalena, Alfaiate, Mário, Rodrigues, Teresa, Pina, Teresa, Rosário, Marta, Silva, Renato, Breda, Jorge, Bazenga, Filipa, Pinto, João António
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Texto Completo: http://hdl.handle.net/10451/57328
Resumo: © The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
id RCAP_2dd46809aa401addf3dabf79eee45f0c
oai_identifier_str oai:repositorio.ulisboa.pt:10451/57328
network_acronym_str RCAP
network_name_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository_id_str https://opendoar.ac.uk/repository/7160
spelling Complete blood count parameters as biomarkers of retinopathy of prematurity: a Portuguese multicenter studyBiomarkerComplete blood countPreterm infantRetinopathy of prematurity© The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.Purpose: To evaluate complete blood count (CBC) parameters in the first week of life as predictive biomarkers for the development of retinopathy of prematurity (ROP). Methods: Multicenter, prospective, observational study of a cohort of preterm infants born with gestational age (GA) < 32 weeks or birth weight < 1500 g in eight Portuguese neonatal intensive care units. All demographic, clinical, and laboratory data from the first week of life were collected. Univariate logistic regression was used to assess risk factors for ROP and then multivariate regression was performed. Results: A total of 455 infants were included in the study. The median GA was 29.6 weeks, and the median birth weight was 1295 g. One hundred and seventy-two infants (37.8%) developed ROP. Median values of erythrocytes (p < 0.001), hemoglobin (p < 0.001), hematocrit (p < 0.001), mean corpuscular hemoglobin concentration (p < 0.001), lymphocytes (p = 0.035), and platelets (p = 0.003) of the group of infants diagnosed with ROP any stage were lower than those without ROP. Mean corpuscular volume (MCV) (p = 0.044), red blood cell distribution width (RDW) (p < 0.001), erythroblasts (p < 0.001), neutrophils (p = 0.030), neutrophils-lymphocytes ratio (p = 0.028), and basophils (p = 0.003) were higher in the ROP group. Higher values of MCV, erythroblasts, and basophils remained significantly associated with ROP after multivariate regression. Conclusion: In our cohort, the increase in erythroblasts, MCV, and basophils in the first week of life was significantly and independently associated with the development of ROP. These CBC parameters may be early predictive biomarkers for ROP.Open access funding provided by FCT|FCCN (b-on). This work was supported by the Laboratório de Genética and the Instituto de Saúde Ambiental (ISAMB) of the Faculdade de Medicina of Universidade de Lisboa and the Instituto de Investigação Científica Bento da Rocha Cabral. The writing of the manuscript was also supported by funds from Fundação para a Ciência e a Tecnologia to ISAMB (ref. UIDB/04295/2020 and UIDP/04295/2020). This work was also part of a doctoral project funding by the company CUF with a PhD grant in Medicine awarded in 2021 and by the Portuguese Society of Ophthalmology with a PhD grant awarded in 2019.Springer NatureRepositório da Universidade de LisboaFevereiro-Martins, MarizaSantos, Ana CarolinaMarques-Neves, CarlosGuimarães, HercíliaBicho, ManuelAfonso, ConceiçãoFerreira, JoanaSanto, Rita EspíritoJorge Teixeira, FilipaRosa, RitaCarneiro, Cristina VazFerreira, MartaMatos, TeresaNeiva, LuísaPereira, SandraAires, SofiaParreira, RicardoMelnik, ZuzanaFaria, JoãoTeixeira, JoanaBarros, PedroAlmeida, JulianaMalheiro, BrunaRodrigues, Patrícia CunhaAlbuquerque, LuísFreitas, AliceKotchekova, NadezdaFreitas, RuiSilveira, Ana CristinaFerreira, AnaMorais, BenvindaTeixeira, SusanaMota, MafaldaGuerra, MariaCoimbra, LúciaGigante, JoãoFerreira, MurielLapa, PatríciaMonteiro, MadalenaAlfaiate, MárioRodrigues, TeresaPina, TeresaRosário, MartaSilva, RenatoBreda, JorgeBazenga, FilipaPinto, João António2023-05-03T13:22:34Z20232023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/57328engGraefes Arch Clin Exp Ophthalmol. 2023;10.1007/s00417-023-06072-70721-832X10.1007/s00417-023-06072-71435-702Xinfo:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-17T14:56:35Zoai:repositorio.ulisboa.pt:10451/57328Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T03:29:29.107265Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Complete blood count parameters as biomarkers of retinopathy of prematurity: a Portuguese multicenter study
title Complete blood count parameters as biomarkers of retinopathy of prematurity: a Portuguese multicenter study
spellingShingle Complete blood count parameters as biomarkers of retinopathy of prematurity: a Portuguese multicenter study
Fevereiro-Martins, Mariza
Biomarker
Complete blood count
Preterm infant
Retinopathy of prematurity
title_short Complete blood count parameters as biomarkers of retinopathy of prematurity: a Portuguese multicenter study
title_full Complete blood count parameters as biomarkers of retinopathy of prematurity: a Portuguese multicenter study
title_fullStr Complete blood count parameters as biomarkers of retinopathy of prematurity: a Portuguese multicenter study
title_full_unstemmed Complete blood count parameters as biomarkers of retinopathy of prematurity: a Portuguese multicenter study
title_sort Complete blood count parameters as biomarkers of retinopathy of prematurity: a Portuguese multicenter study
author Fevereiro-Martins, Mariza
author_facet Fevereiro-Martins, Mariza
Santos, Ana Carolina
Marques-Neves, Carlos
Guimarães, Hercília
Bicho, Manuel
Afonso, Conceição
Ferreira, Joana
Santo, Rita Espírito
Jorge Teixeira, Filipa
Rosa, Rita
Carneiro, Cristina Vaz
Ferreira, Marta
Matos, Teresa
Neiva, Luísa
Pereira, Sandra
Aires, Sofia
Parreira, Ricardo
Melnik, Zuzana
Faria, João
Teixeira, Joana
Barros, Pedro
Almeida, Juliana
Malheiro, Bruna
Rodrigues, Patrícia Cunha
Albuquerque, Luís
Freitas, Alice
Kotchekova, Nadezda
Freitas, Rui
Silveira, Ana Cristina
Ferreira, Ana
Morais, Benvinda
Teixeira, Susana
Mota, Mafalda
Guerra, Maria
Coimbra, Lúcia
Gigante, João
Ferreira, Muriel
Lapa, Patrícia
Monteiro, Madalena
Alfaiate, Mário
Rodrigues, Teresa
Pina, Teresa
Rosário, Marta
Silva, Renato
Breda, Jorge
Bazenga, Filipa
Pinto, João António
author_role author
author2 Santos, Ana Carolina
Marques-Neves, Carlos
Guimarães, Hercília
Bicho, Manuel
Afonso, Conceição
Ferreira, Joana
Santo, Rita Espírito
Jorge Teixeira, Filipa
Rosa, Rita
Carneiro, Cristina Vaz
Ferreira, Marta
Matos, Teresa
Neiva, Luísa
Pereira, Sandra
Aires, Sofia
Parreira, Ricardo
Melnik, Zuzana
Faria, João
Teixeira, Joana
Barros, Pedro
Almeida, Juliana
Malheiro, Bruna
Rodrigues, Patrícia Cunha
Albuquerque, Luís
Freitas, Alice
Kotchekova, Nadezda
Freitas, Rui
Silveira, Ana Cristina
Ferreira, Ana
Morais, Benvinda
Teixeira, Susana
Mota, Mafalda
Guerra, Maria
Coimbra, Lúcia
Gigante, João
Ferreira, Muriel
Lapa, Patrícia
Monteiro, Madalena
Alfaiate, Mário
Rodrigues, Teresa
Pina, Teresa
Rosário, Marta
Silva, Renato
Breda, Jorge
Bazenga, Filipa
Pinto, João António
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Fevereiro-Martins, Mariza
Santos, Ana Carolina
Marques-Neves, Carlos
Guimarães, Hercília
Bicho, Manuel
Afonso, Conceição
Ferreira, Joana
Santo, Rita Espírito
Jorge Teixeira, Filipa
Rosa, Rita
Carneiro, Cristina Vaz
Ferreira, Marta
Matos, Teresa
Neiva, Luísa
Pereira, Sandra
Aires, Sofia
Parreira, Ricardo
Melnik, Zuzana
Faria, João
Teixeira, Joana
Barros, Pedro
Almeida, Juliana
Malheiro, Bruna
Rodrigues, Patrícia Cunha
Albuquerque, Luís
Freitas, Alice
Kotchekova, Nadezda
Freitas, Rui
Silveira, Ana Cristina
Ferreira, Ana
Morais, Benvinda
Teixeira, Susana
Mota, Mafalda
Guerra, Maria
Coimbra, Lúcia
Gigante, João
Ferreira, Muriel
Lapa, Patrícia
Monteiro, Madalena
Alfaiate, Mário
Rodrigues, Teresa
Pina, Teresa
Rosário, Marta
Silva, Renato
Breda, Jorge
Bazenga, Filipa
Pinto, João António
dc.subject.por.fl_str_mv Biomarker
Complete blood count
Preterm infant
Retinopathy of prematurity
topic Biomarker
Complete blood count
Preterm infant
Retinopathy of prematurity
description © The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
publishDate 2023
dc.date.none.fl_str_mv 2023-05-03T13:22:34Z
2023
2023-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/57328
url http://hdl.handle.net/10451/57328
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Graefes Arch Clin Exp Ophthalmol. 2023;10.1007/s00417-023-06072-7
0721-832X
10.1007/s00417-023-06072-7
1435-702X
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833601718551576576