Metastatic organotropism: a brief overview

Bibliographic Details
Main Author: Carrolo, M
Publication Date: 2024
Other Authors: Miranda, JA, Vilhais, G, Quintela, A, Fontes e Sousa, M, Alpuim-Costa, D, Pinto, FR
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10400.26/50855
Summary: Organotropism has been known since 1889, yet this vital component of metastasis has predominantly stayed elusive. This mini-review gives an overview of the current understanding of the underlying mechanisms of organotropism and metastases development by focusing on the formation of the pre-metastatic niche, immune defenses against metastases, and genomic alterations associated with organotropism. The particular case of brain metastases is also addressed, as well as the impact of organotropism in cancer therapy. The limited comprehension of the factors behind organotropism underscores the necessity for efficient strategies and treatments to manage metastases.
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spelling Metastatic organotropism: a brief overviewNeoplasiasMicroambiente TumoralNeoplasmsTumor MicroenvironmentOrganotropism has been known since 1889, yet this vital component of metastasis has predominantly stayed elusive. This mini-review gives an overview of the current understanding of the underlying mechanisms of organotropism and metastases development by focusing on the formation of the pre-metastatic niche, immune defenses against metastases, and genomic alterations associated with organotropism. The particular case of brain metastases is also addressed, as well as the impact of organotropism in cancer therapy. The limited comprehension of the factors behind organotropism underscores the necessity for efficient strategies and treatments to manage metastases.Repositório ComumCarrolo, MMiranda, JAVilhais, GQuintela, AFontes e Sousa, MAlpuim-Costa, DPinto, FR2024-05-19T20:48:43Z20242024-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.26/50855eng10.3389/fonc.2024.1358786info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-05-10T10:10:15Zoai:comum.rcaap.pt:10400.26/50855Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T07:07:34.203147Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Metastatic organotropism: a brief overview
title Metastatic organotropism: a brief overview
spellingShingle Metastatic organotropism: a brief overview
Carrolo, M
Neoplasias
Microambiente Tumoral
Neoplasms
Tumor Microenvironment
title_short Metastatic organotropism: a brief overview
title_full Metastatic organotropism: a brief overview
title_fullStr Metastatic organotropism: a brief overview
title_full_unstemmed Metastatic organotropism: a brief overview
title_sort Metastatic organotropism: a brief overview
author Carrolo, M
author_facet Carrolo, M
Miranda, JA
Vilhais, G
Quintela, A
Fontes e Sousa, M
Alpuim-Costa, D
Pinto, FR
author_role author
author2 Miranda, JA
Vilhais, G
Quintela, A
Fontes e Sousa, M
Alpuim-Costa, D
Pinto, FR
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Comum
dc.contributor.author.fl_str_mv Carrolo, M
Miranda, JA
Vilhais, G
Quintela, A
Fontes e Sousa, M
Alpuim-Costa, D
Pinto, FR
dc.subject.por.fl_str_mv Neoplasias
Microambiente Tumoral
Neoplasms
Tumor Microenvironment
topic Neoplasias
Microambiente Tumoral
Neoplasms
Tumor Microenvironment
description Organotropism has been known since 1889, yet this vital component of metastasis has predominantly stayed elusive. This mini-review gives an overview of the current understanding of the underlying mechanisms of organotropism and metastases development by focusing on the formation of the pre-metastatic niche, immune defenses against metastases, and genomic alterations associated with organotropism. The particular case of brain metastases is also addressed, as well as the impact of organotropism in cancer therapy. The limited comprehension of the factors behind organotropism underscores the necessity for efficient strategies and treatments to manage metastases.
publishDate 2024
dc.date.none.fl_str_mv 2024-05-19T20:48:43Z
2024
2024-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.26/50855
url http://hdl.handle.net/10400.26/50855
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.3389/fonc.2024.1358786
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
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reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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