Functional studies on magnetic resonance

Bibliographic Details
Main Author: Miranda, João Pedro Ribeiro
Publication Date: 2010
Format: Master thesis
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/4941
Summary: Dissertation submitted in Faculdade de Ciências e Tecnologia of Universidade Nova de Lisboa for the degree of Master in Biomedical Engineering
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spelling Functional studies on magnetic resonanceFunctional magnetic resonance imaging (fMRI)Cerebral blood flow (CBF)Dissertation submitted in Faculdade de Ciências e Tecnologia of Universidade Nova de Lisboa for the degree of Master in Biomedical EngineeringBackground: Magnetic Resonance Imaging (MRI) is an imaging technique used primarily to produce high quality structural and functional images of the human body. Functional MRI techniques, among which are included the Arterial Spin Labeling (ASL) and the Blood Oxygenation Level-Dependent (BOLD), are used to measure brain activity. Several studies have shown that ASL holds several advantages when compared with BOLD, namely the fact of being more reproducible and perfusion quantitative. Purpose: The main aim of this work is to obtain perfusion quantification of the human brain within several of its territories and to compare the results obtained using two different ASL protocols. Secondarily this study aimed to validate an ASL protocol to be used in clinical exams – Protocol #2 by comparing the values obtained for all the regions considered with the ones present in literature. Methods: The methodology used in this study was applied to fifteen adult volunteers. Two ASL protocols were used in a single functional imaging session. Subjects were asked to perform a motor finger tapping task with their right hand while being scanned. Images were acquired on a 3 Tesla equipment – Magnetom Verio MRI System from SIEMENS in Hospital da Luz. For the definition of the regions to study the Talairach anatomical atlas was used and the brain was segmented considering five different segmentation levels. Results: Perfusion quantification studies have demonstrated that ASL allows a correct calculation of Cerebral Blood Flow (CBF), especially when compared to other studies which used other invasive perfusion measuring techniques. The perfusion values obtained for several regions considered are in agreement with the ones available in literature. Conclusions: ASL protocols are now becoming commercially available and have been demonstrating coherent results with other techniques already established. The current study presents one of the first detailed perfusion studies using this technique to evaluate several structures of the brain. The adequacy of Protocol 2 for functional studies was also proved considering the stimulus used.Faculdade de Ciências e TecnologiaPereira, CarlaJanela, FilipeRUNMiranda, João Pedro Ribeiro2011-01-21T14:34:24Z20102010-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://hdl.handle.net/10362/4941enginfo:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T17:08:12Zoai:run.unl.pt:10362/4941Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T16:39:14.787853Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Functional studies on magnetic resonance
title Functional studies on magnetic resonance
spellingShingle Functional studies on magnetic resonance
Miranda, João Pedro Ribeiro
Functional magnetic resonance imaging (fMRI)
Cerebral blood flow (CBF)
title_short Functional studies on magnetic resonance
title_full Functional studies on magnetic resonance
title_fullStr Functional studies on magnetic resonance
title_full_unstemmed Functional studies on magnetic resonance
title_sort Functional studies on magnetic resonance
author Miranda, João Pedro Ribeiro
author_facet Miranda, João Pedro Ribeiro
author_role author
dc.contributor.none.fl_str_mv Pereira, Carla
Janela, Filipe
RUN
dc.contributor.author.fl_str_mv Miranda, João Pedro Ribeiro
dc.subject.por.fl_str_mv Functional magnetic resonance imaging (fMRI)
Cerebral blood flow (CBF)
topic Functional magnetic resonance imaging (fMRI)
Cerebral blood flow (CBF)
description Dissertation submitted in Faculdade de Ciências e Tecnologia of Universidade Nova de Lisboa for the degree of Master in Biomedical Engineering
publishDate 2010
dc.date.none.fl_str_mv 2010
2010-01-01T00:00:00Z
2011-01-21T14:34:24Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/4941
url http://hdl.handle.net/10362/4941
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Faculdade de Ciências e Tecnologia
publisher.none.fl_str_mv Faculdade de Ciências e Tecnologia
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
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instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
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reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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