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Enzymes present in neutrophil extracellular traps may stimulate the fibrogenic PGF(2 alpha) pathway in the mare endometrium

Bibliographic Details
Main Author: Rebordão, Maria Rosa
Publication Date: 2021
Other Authors: Amaral, Ana, Fernandes, Carina, Silva, E, Lukasik, Karolina, Szóstek-Mioduchowska, Anna, Bravo, Pedro, Galvão, António, Skarzynski, Dariusz J., Ferreira-Dias, Graça
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10400.5/22466
Summary: Research Areas: AgricultureVeterinary Sciences
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spelling Enzymes present in neutrophil extracellular traps may stimulate the fibrogenic PGF(2 alpha) pathway in the mare endometriumNeutrophil extracellular trapsFibrosisEndometriumEndometrosisHorsePGF2αPGF2α receptorResearch Areas: AgricultureVeterinary SciencesEndometrosis is a fibrotic disease in mare endometrium whose pathological mechanisms remain obscure. Prostaglandin (PG)F2α, despite modulating reproductive physiological processes, may also provoke local pathological collagen deposition (fibrogenesis). Neutrophil extracellular traps (NETs) released during inflammation have been linked to fibrogenesis in several tissues. We have previously shown that enzymes found in NETs increase in vitro collagen production in mare endometrium. In this study, activation of PGF2α-pathway in equine endometrial explants challenged in vitro by enzymes found in NETs is shown. Our results indicate that both endocrine microenvironment (estrous cycle phase) and healthy or pathological conditions of endometrial tissues play an important role in PGF2α-pathway activation. In the endometrium of the follicular phase, we have observed both high production of PGF2α and/or PGF2α receptor gene transcription under the action of enzymes found in NETs, both conditions associated with fibrogenesis in other tissues. Nevertheless, transcription of the PGF2α receptor gene does not appear to be hormone-dependent, albeit their levels seem to be dependent on endometrial category in the mid-luteal phase. This study suggests that enzymes existing in NETs may instigate changes on PGF2α mediators, which may become an additional mechanism of fibrogenesis in mare endometrium.MDPIRepositório da Universidade de LisboaRebordão, Maria RosaAmaral, AnaFernandes, CarinaSilva, ELukasik, KarolinaSzóstek-Mioduchowska, AnnaBravo, PedroGalvão, AntónioSkarzynski, Dariusz J.Ferreira-Dias, Graça2021-11-03T00:11:45Z2021-09-062021-09-06T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.5/22466engRebordão MR, Amaral A, Fernandes C, Silva E, Lukasik K, Szóstek-Mioduchowska A, Pinto-Bravo P, Galvão A, Skarzynski DJ, Ferreira-Dias G. 2021 Enzymes present in neutrophil extracellular traps may stimulate the fibrogenic PGF(2 alpha) pathway in the mare endometriumm. Animals 11:2615. DOI:10.3390/ani110926152076-261510.3390/ani11092615info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-17T15:24:16Zoai:repositorio.ulisboa.pt:10400.5/22466Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T03:42:24.264001Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Enzymes present in neutrophil extracellular traps may stimulate the fibrogenic PGF(2 alpha) pathway in the mare endometrium
title Enzymes present in neutrophil extracellular traps may stimulate the fibrogenic PGF(2 alpha) pathway in the mare endometrium
spellingShingle Enzymes present in neutrophil extracellular traps may stimulate the fibrogenic PGF(2 alpha) pathway in the mare endometrium
Rebordão, Maria Rosa
Neutrophil extracellular traps
Fibrosis
Endometrium
Endometrosis
Horse
PGF2α
PGF2α receptor
title_short Enzymes present in neutrophil extracellular traps may stimulate the fibrogenic PGF(2 alpha) pathway in the mare endometrium
title_full Enzymes present in neutrophil extracellular traps may stimulate the fibrogenic PGF(2 alpha) pathway in the mare endometrium
title_fullStr Enzymes present in neutrophil extracellular traps may stimulate the fibrogenic PGF(2 alpha) pathway in the mare endometrium
title_full_unstemmed Enzymes present in neutrophil extracellular traps may stimulate the fibrogenic PGF(2 alpha) pathway in the mare endometrium
title_sort Enzymes present in neutrophil extracellular traps may stimulate the fibrogenic PGF(2 alpha) pathway in the mare endometrium
author Rebordão, Maria Rosa
author_facet Rebordão, Maria Rosa
Amaral, Ana
Fernandes, Carina
Silva, E
Lukasik, Karolina
Szóstek-Mioduchowska, Anna
Bravo, Pedro
Galvão, António
Skarzynski, Dariusz J.
Ferreira-Dias, Graça
author_role author
author2 Amaral, Ana
Fernandes, Carina
Silva, E
Lukasik, Karolina
Szóstek-Mioduchowska, Anna
Bravo, Pedro
Galvão, António
Skarzynski, Dariusz J.
Ferreira-Dias, Graça
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Rebordão, Maria Rosa
Amaral, Ana
Fernandes, Carina
Silva, E
Lukasik, Karolina
Szóstek-Mioduchowska, Anna
Bravo, Pedro
Galvão, António
Skarzynski, Dariusz J.
Ferreira-Dias, Graça
dc.subject.por.fl_str_mv Neutrophil extracellular traps
Fibrosis
Endometrium
Endometrosis
Horse
PGF2α
PGF2α receptor
topic Neutrophil extracellular traps
Fibrosis
Endometrium
Endometrosis
Horse
PGF2α
PGF2α receptor
description Research Areas: AgricultureVeterinary Sciences
publishDate 2021
dc.date.none.fl_str_mv 2021-11-03T00:11:45Z
2021-09-06
2021-09-06T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.5/22466
url http://hdl.handle.net/10400.5/22466
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Rebordão MR, Amaral A, Fernandes C, Silva E, Lukasik K, Szóstek-Mioduchowska A, Pinto-Bravo P, Galvão A, Skarzynski DJ, Ferreira-Dias G. 2021 Enzymes present in neutrophil extracellular traps may stimulate the fibrogenic PGF(2 alpha) pathway in the mare endometriumm. Animals 11:2615. DOI:10.3390/ani11092615
2076-2615
10.3390/ani11092615
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833601801987817472

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