Clinical outcomes and patient-matched molecular composition of relapsed medulloblastoma

Kumar, Rahul; Smith, Kyle S.; Deng, Maximilian; Terhune, Colt; Robinson, Giles W; Orr, Brent A.; Liu, Anthony P. Y.; Lin, Tong; Billups, Catherine A.; Chintagumpala, Murali; Bowers, Daniel C.; Hassall, Timothy E.; Hansford, Jordan R.; Khuong-Quang, Dong Anh; Crawford, John R.; Bendel, Anne E.; Gururangan, Sridharan; Schroeder, Kristin; Bouffet, Eric; Bartels, Ute; Fisher, Michael J.; Cohn, Richard; Partap, Sonia; Kellie, Stewart J.; McCowage, Geoffrey; Paulino, Arnold C.; Rutkowski, Stefan; Fleischhack, Gudrun; Dhall, Girish; Klesse, Laura J.; Leary, Sarah; Nazarian, Javad; Kool, Marcel; Wesseling, Pieter; Ryzhova, Marina; Zheludkova, Olga; Golanov, Andrey V.; McLendon, Roger E.; Packer, Roger J.; Dunham, Christopher; Hukin, Juliette; Fouladi, Maryam; Faria, Claudia; Pimentel, José; Walter, Andrew W.; Jabado, Nada; Cho, Yoon-Jae; Perreault, Sebastien; Croul, Sidney E.; Zapotocky, Michal; Hawkins, Cynthia; Tabori, Uri; Taylor, Michael D.; Pfister, Stefan M.; Klimo, Paul; Boop, Frederick A.; Ellison, David W.; Merchant, Thomas E.; Onar-Thomas, Arzu; Korshunov, Andrey; Jones, David T. W.; Gajjar, Amar; Ramaswamy, Vijay; Northcott, Paul A.

Clinical outcomes and patient-matched molecular composition of relapsed medulloblastoma

Bibliographic Details
Main Author:	Kumar, Rahul
Publication Date:	2021
Other Authors:	Smith, Kyle S., Deng, Maximilian, Terhune, Colt, Robinson, Giles W, Orr, Brent A., Liu, Anthony P. Y., Lin, Tong, Billups, Catherine A., Chintagumpala, Murali, Bowers, Daniel C., Hassall, Timothy E., Hansford, Jordan R., Khuong-Quang, Dong Anh, Crawford, John R., Bendel, Anne E., Gururangan, Sridharan, Schroeder, Kristin, Bouffet, Eric, Bartels, Ute, Fisher, Michael J., Cohn, Richard, Partap, Sonia, Kellie, Stewart J., McCowage, Geoffrey, Paulino, Arnold C., Rutkowski, Stefan, Fleischhack, Gudrun, Dhall, Girish, Klesse, Laura J., Leary, Sarah, Nazarian, Javad, Kool, Marcel, Wesseling, Pieter, Ryzhova, Marina, Zheludkova, Olga, Golanov, Andrey V., McLendon, Roger E., Packer, Roger J., Dunham, Christopher, Hukin, Juliette, Fouladi, Maryam, Faria, Claudia, Pimentel, José, Walter, Andrew W., Jabado, Nada, Cho, Yoon-Jae, Perreault, Sebastien, Croul, Sidney E., Zapotocky, Michal, Hawkins, Cynthia, Tabori, Uri, Taylor, Michael D., Pfister, Stefan M., Klimo, Paul, Boop, Frederick A., Ellison, David W., Merchant, Thomas E., Onar-Thomas, Arzu, Korshunov, Andrey, Jones, David T. W., Gajjar, Amar, Ramaswamy, Vijay, Northcott, Paul A.
Format:	Article
Language:	eng
Source:	Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full:	http://hdl.handle.net/10451/46204
Summary:	© 2021 by American Society of Clinical Oncology. Creative Commons Attribution Non-Commercial No Derivatives 4.0 License: https://creativecommons.org/licenses/by-nc-nd/4.0/

Item metadata

id	RCAP_2317ede20c461a684f807002c96b0a7d
oai_identifier_str	oai:repositorio.ulisboa.pt:10451/46204
network_acronym_str	RCAP
network_name_str	Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository_id_str	https://opendoar.ac.uk/repository/7160
spelling	Clinical outcomes and patient-matched molecular composition of relapsed medulloblastoma© 2021 by American Society of Clinical Oncology. Creative Commons Attribution Non-Commercial No Derivatives 4.0 License: https://creativecommons.org/licenses/by-nc-nd/4.0/Purpose: We sought to investigate clinical outcomes of relapsed medulloblastoma and to compare molecular features between patient-matched diagnostic and relapsed tumors. Methods: Children and infants enrolled on either SJMB03 (NCT00085202) or SJYC07 (NCT00602667) trials who experienced medulloblastoma relapse were analyzed for clinical outcomes, including anatomic and temporal patterns of relapse and postrelapse survival. A largely independent, paired molecular cohort was analyzed by DNA methylation array and next-generation sequencing. Results: A total of 72 of 329 (22%) SJMB03 and 52 of 79 (66%) SJYC07 patients experienced relapse with significant representation of Group 3 and wingless tumors. Although most patients exhibited some distal disease (79%), 38% of patients with sonic hedgehog tumors experienced isolated local relapse. Time to relapse and postrelapse survival varied by molecular subgroup with longer latencies for patients with Group 4 tumors. Postrelapse radiation therapy among previously nonirradiated SJYC07 patients was associated with long-term survival. Reirradiation was only temporizing for SJMB03 patients. Among 127 patients with patient-matched tumor pairs, 9 (7%) experienced subsequent nonmedulloblastoma CNS malignancies. Subgroup (96%) and subtype (80%) stabilities were largely maintained among the remainder. Rare subgroup divergence was observed from Group 4 to Group 3 tumors, which is coincident with genetic alterations involving MYC, MYCN, and FBXW7. Subgroup-specific patterns of alteration were identified for driver genes and chromosome arms. Conclusion: Clinical behavior of relapsed medulloblastoma must be contextualized in terms of up-front therapies and molecular classifications. Group 4 tumors exhibit slower biological progression. Utility of radiation at relapse is dependent on patient age and prior treatments. Degree and patterns of molecular conservation at relapse vary by subgroup. Relapse tissue enables verification of molecular targets and identification of occult secondary malignancies.American Society of Clinical OncologyRepositório da Universidade de LisboaKumar, RahulSmith, Kyle S.Deng, MaximilianTerhune, ColtRobinson, Giles WOrr, Brent A.Liu, Anthony P. Y.Lin, TongBillups, Catherine A.Chintagumpala, MuraliBowers, Daniel C.Hassall, Timothy E.Hansford, Jordan R.Khuong-Quang, Dong AnhCrawford, John R.Bendel, Anne E.Gururangan, SridharanSchroeder, KristinBouffet, EricBartels, UteFisher, Michael J.Cohn, RichardPartap, SoniaKellie, Stewart J.McCowage, GeoffreyPaulino, Arnold C.Rutkowski, StefanFleischhack, GudrunDhall, GirishKlesse, Laura J.Leary, SarahNazarian, JavadKool, MarcelWesseling, PieterRyzhova, MarinaZheludkova, OlgaGolanov, Andrey V.McLendon, Roger E.Packer, Roger J.Dunham, ChristopherHukin, JulietteFouladi, MaryamFaria, ClaudiaPimentel, JoséWalter, Andrew W.Jabado, NadaCho, Yoon-JaePerreault, SebastienCroul, Sidney E.Zapotocky, MichalHawkins, CynthiaTabori, UriTaylor, Michael D.Pfister, Stefan M.Klimo, PaulBoop, Frederick A.Ellison, David W.Merchant, Thomas E.Onar-Thomas, ArzuKorshunov, AndreyJones, David T. W.Gajjar, AmarRamaswamy, VijayNorthcott, Paul A.2021-02-05T13:14:57Z2021-01-272021-01-27T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/46204engJ Clin Oncol. 2021 Jan 27:JCO20013590732-183X10.1200/JCO.20.013591527-7755info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-17T14:28:07Zoai:repositorio.ulisboa.pt:10451/46204Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T03:12:46.442435Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv	Clinical outcomes and patient-matched molecular composition of relapsed medulloblastoma
title	Clinical outcomes and patient-matched molecular composition of relapsed medulloblastoma
spellingShingle	Clinical outcomes and patient-matched molecular composition of relapsed medulloblastoma Kumar, Rahul
title_short	Clinical outcomes and patient-matched molecular composition of relapsed medulloblastoma
title_full	Clinical outcomes and patient-matched molecular composition of relapsed medulloblastoma
title_fullStr	Clinical outcomes and patient-matched molecular composition of relapsed medulloblastoma
title_full_unstemmed	Clinical outcomes and patient-matched molecular composition of relapsed medulloblastoma
title_sort	Clinical outcomes and patient-matched molecular composition of relapsed medulloblastoma
author	Kumar, Rahul
author_facet	Kumar, Rahul Smith, Kyle S. Deng, Maximilian Terhune, Colt Robinson, Giles W Orr, Brent A. Liu, Anthony P. Y. Lin, Tong Billups, Catherine A. Chintagumpala, Murali Bowers, Daniel C. Hassall, Timothy E. Hansford, Jordan R. Khuong-Quang, Dong Anh Crawford, John R. Bendel, Anne E. Gururangan, Sridharan Schroeder, Kristin Bouffet, Eric Bartels, Ute Fisher, Michael J. Cohn, Richard Partap, Sonia Kellie, Stewart J. McCowage, Geoffrey Paulino, Arnold C. Rutkowski, Stefan Fleischhack, Gudrun Dhall, Girish Klesse, Laura J. Leary, Sarah Nazarian, Javad Kool, Marcel Wesseling, Pieter Ryzhova, Marina Zheludkova, Olga Golanov, Andrey V. McLendon, Roger E. Packer, Roger J. Dunham, Christopher Hukin, Juliette Fouladi, Maryam Faria, Claudia Pimentel, José Walter, Andrew W. Jabado, Nada Cho, Yoon-Jae Perreault, Sebastien Croul, Sidney E. Zapotocky, Michal Hawkins, Cynthia Tabori, Uri Taylor, Michael D. Pfister, Stefan M. Klimo, Paul Boop, Frederick A. Ellison, David W. Merchant, Thomas E. Onar-Thomas, Arzu Korshunov, Andrey Jones, David T. W. Gajjar, Amar Ramaswamy, Vijay Northcott, Paul A.
author_role	author
author2	Smith, Kyle S. Deng, Maximilian Terhune, Colt Robinson, Giles W Orr, Brent A. Liu, Anthony P. Y. Lin, Tong Billups, Catherine A. Chintagumpala, Murali Bowers, Daniel C. Hassall, Timothy E. Hansford, Jordan R. Khuong-Quang, Dong Anh Crawford, John R. Bendel, Anne E. Gururangan, Sridharan Schroeder, Kristin Bouffet, Eric Bartels, Ute Fisher, Michael J. Cohn, Richard Partap, Sonia Kellie, Stewart J. McCowage, Geoffrey Paulino, Arnold C. Rutkowski, Stefan Fleischhack, Gudrun Dhall, Girish Klesse, Laura J. Leary, Sarah Nazarian, Javad Kool, Marcel Wesseling, Pieter Ryzhova, Marina Zheludkova, Olga Golanov, Andrey V. McLendon, Roger E. Packer, Roger J. Dunham, Christopher Hukin, Juliette Fouladi, Maryam Faria, Claudia Pimentel, José Walter, Andrew W. Jabado, Nada Cho, Yoon-Jae Perreault, Sebastien Croul, Sidney E. Zapotocky, Michal Hawkins, Cynthia Tabori, Uri Taylor, Michael D. Pfister, Stefan M. Klimo, Paul Boop, Frederick A. Ellison, David W. Merchant, Thomas E. Onar-Thomas, Arzu Korshunov, Andrey Jones, David T. W. Gajjar, Amar Ramaswamy, Vijay Northcott, Paul A.
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv	Kumar, Rahul Smith, Kyle S. Deng, Maximilian Terhune, Colt Robinson, Giles W Orr, Brent A. Liu, Anthony P. Y. Lin, Tong Billups, Catherine A. Chintagumpala, Murali Bowers, Daniel C. Hassall, Timothy E. Hansford, Jordan R. Khuong-Quang, Dong Anh Crawford, John R. Bendel, Anne E. Gururangan, Sridharan Schroeder, Kristin Bouffet, Eric Bartels, Ute Fisher, Michael J. Cohn, Richard Partap, Sonia Kellie, Stewart J. McCowage, Geoffrey Paulino, Arnold C. Rutkowski, Stefan Fleischhack, Gudrun Dhall, Girish Klesse, Laura J. Leary, Sarah Nazarian, Javad Kool, Marcel Wesseling, Pieter Ryzhova, Marina Zheludkova, Olga Golanov, Andrey V. McLendon, Roger E. Packer, Roger J. Dunham, Christopher Hukin, Juliette Fouladi, Maryam Faria, Claudia Pimentel, José Walter, Andrew W. Jabado, Nada Cho, Yoon-Jae Perreault, Sebastien Croul, Sidney E. Zapotocky, Michal Hawkins, Cynthia Tabori, Uri Taylor, Michael D. Pfister, Stefan M. Klimo, Paul Boop, Frederick A. Ellison, David W. Merchant, Thomas E. Onar-Thomas, Arzu Korshunov, Andrey Jones, David T. W. Gajjar, Amar Ramaswamy, Vijay Northcott, Paul A.
description	© 2021 by American Society of Clinical Oncology. Creative Commons Attribution Non-Commercial No Derivatives 4.0 License: https://creativecommons.org/licenses/by-nc-nd/4.0/
publishDate	2021
dc.date.none.fl_str_mv	2021-02-05T13:14:57Z 2021-01-27 2021-01-27T00:00:00Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.uri.fl_str_mv	http://hdl.handle.net/10451/46204
url	http://hdl.handle.net/10451/46204
dc.language.iso.fl_str_mv	eng
language	eng
dc.relation.none.fl_str_mv	J Clin Oncol. 2021 Jan 27:JCO2001359 0732-183X 10.1200/JCO.20.01359 1527-7755
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	American Society of Clinical Oncology
publisher.none.fl_str_mv	American Society of Clinical Oncology
dc.source.none.fl_str_mv	reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia instacron:RCAAP
instname_str	FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str	RCAAP
institution	RCAAP
reponame_str	Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection	Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv	Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv	info@rcaap.pt
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Clinical outcomes and patient-matched molecular composition of relapsed medulloblastoma

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