Dietary (poly)phenols in traumatic brain injury

Bibliographic Details
Main Author: Carecho, Rafael
Publication Date: 2023
Other Authors: Carregosa, Diogo, Ratilal, Bernardo, Figueira, Inês, Ávila-Gálvez, Maria Angeles, dos Santos, Cláudia Nunes, Loncarevic-Vasiljkovic, Natasa
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10451/57690
Summary: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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spelling Dietary (poly)phenols in traumatic brain injuryInflammationNeurodegenerationOxidative stressSecondary brain injury© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).Traumatic brain injury (TBI) remains one of the leading causes of death and disability in young adults worldwide. Despite growing evidence and advances in our knowledge regarding the multifaceted pathophysiology of TBI, the underlying mechanisms, though, are still to be fully elucidated. Whereas initial brain insult involves acute and irreversible primary damage to the brain, the processes of subsequent secondary brain injury progress gradually over months to years, providing a window of opportunity for therapeutic interventions. To date, extensive research has been focused on the identification of druggable targets involved in these processes. Despite several decades of successful pre-clinical studies and very promising results, when transferred to clinics, these drugs showed, at best, modest beneficial effects, but more often, an absence of effects or even very harsh side effects in TBI patients. This reality has highlighted the need for novel approaches that will be able to respond to the complexity of the TBI and tackle TBI pathological processes on multiple levels. Recent evidence strongly indicates that nutritional interventions may provide a unique opportunity to enhance the repair processes after TBI. Dietary (poly)phenols, a big class of compounds abundantly found in fruits and vegetables, have emerged in the past few years as promising agents to be used in TBI settings due to their proven pleiotropic effects. Here, we give an overview of the pathophysiology of TBI and the underlying molecular mechanisms, followed by a state-of-the-art summary of the studies that have evaluated the efficacy of (poly)phenols administration to decrease TBI-associated damage in various animal TBI models and in a limited number of clinical trials. The current limitations on our knowledge concerning (poly)phenol effects in TBI in the pre-clinical studies are also discussed.This research was funded by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program under grant agreement No 804229. iNOVA4Health Research Unit (LISBOA-01-0145-FEDER-007344), which is co-funded by Fundação para a Ciência e Tecnologia (FCT)/Ministério da Ciência e do Ensino Superior, through national funds, and by FEDER under the PT2020 Partnership Agreement, is acknowledged (UIDB/04462/2020 and UIDP/04462/2020) as well LS4FUTURE Associated Laboratory (LA/P/0087/2020). The authors would like to acknowledge FCT for financial support: RC (PD/BD/135492/2018) DC (2020.04630.BD); IF (2022.00151.CEECIND).MDPIRepositório da Universidade de LisboaCarecho, RafaelCarregosa, DiogoRatilal, BernardoFigueira, InêsÁvila-Gálvez, Maria Angelesdos Santos, Cláudia NunesLoncarevic-Vasiljkovic, Natasa2023-05-30T13:30:09Z20232023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/57690engInt J Mol Sci. 2023 May 17;24(10):89081661-659610.3390/ijms241089081422-0067info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-17T14:57:46Zoai:repositorio.ulisboa.pt:10451/57690Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T03:30:21.485562Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Dietary (poly)phenols in traumatic brain injury
title Dietary (poly)phenols in traumatic brain injury
spellingShingle Dietary (poly)phenols in traumatic brain injury
Carecho, Rafael
Inflammation
Neurodegeneration
Oxidative stress
Secondary brain injury
title_short Dietary (poly)phenols in traumatic brain injury
title_full Dietary (poly)phenols in traumatic brain injury
title_fullStr Dietary (poly)phenols in traumatic brain injury
title_full_unstemmed Dietary (poly)phenols in traumatic brain injury
title_sort Dietary (poly)phenols in traumatic brain injury
author Carecho, Rafael
author_facet Carecho, Rafael
Carregosa, Diogo
Ratilal, Bernardo
Figueira, Inês
Ávila-Gálvez, Maria Angeles
dos Santos, Cláudia Nunes
Loncarevic-Vasiljkovic, Natasa
author_role author
author2 Carregosa, Diogo
Ratilal, Bernardo
Figueira, Inês
Ávila-Gálvez, Maria Angeles
dos Santos, Cláudia Nunes
Loncarevic-Vasiljkovic, Natasa
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Carecho, Rafael
Carregosa, Diogo
Ratilal, Bernardo
Figueira, Inês
Ávila-Gálvez, Maria Angeles
dos Santos, Cláudia Nunes
Loncarevic-Vasiljkovic, Natasa
dc.subject.por.fl_str_mv Inflammation
Neurodegeneration
Oxidative stress
Secondary brain injury
topic Inflammation
Neurodegeneration
Oxidative stress
Secondary brain injury
description © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
publishDate 2023
dc.date.none.fl_str_mv 2023-05-30T13:30:09Z
2023
2023-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/57690
url http://hdl.handle.net/10451/57690
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Int J Mol Sci. 2023 May 17;24(10):8908
1661-6596
10.3390/ijms24108908
1422-0067
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
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reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
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repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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