Carboxyhemoglobin (COHb)

Bibliographic Details
Main Author: Carrola, André
Publication Date: 2023
Other Authors: Romão, Carlos C., Vieira, Helena L. A.
Format: Other
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/158007
Summary: Publisher Copyright: © 2023 by the authors.
id RCAP_21e4aa1f793964e9fa525fbdb28e28cc
oai_identifier_str oai:run.unl.pt:10362/158007
network_acronym_str RCAP
network_name_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository_id_str https://opendoar.ac.uk/repository/7160
spelling Carboxyhemoglobin (COHb)Unavoidable Bystander or Protective Player?carbon monoxidecarboxyhemoglobincytoprotectionhemoglobinoxidative stressFood SciencePhysiologyBiochemistryMolecular BiologyClinical BiochemistryCell BiologyPublisher Copyright: © 2023 by the authors.Carbon monoxide (CO) is a cytoprotective endogenous gas that is ubiquitously produced by the stress response enzyme heme-oxygenase. Being a gas, CO rapidly diffuses through tissues and binds to hemoglobin (Hb) increasing carboxyhemoglobin (COHb) levels. COHb can be formed in erythrocytes or in plasma from cell-free Hb. Herein, it is discussed as to whether endogenous COHb is an innocuous and inevitable metabolic waste product or not, and it is hypothesized that COHb has a biological role. In the present review, literature data are presented to support this hypothesis based on two main premises: (i) there is no direct correlation between COHb levels and CO toxicity, and (ii) COHb seems to have a direct cytoprotective and antioxidant role in erythrocytes and in hemorrhagic models in vivo. Moreover, CO is also an antioxidant by generating COHb, which protects against the pro-oxidant damaging effects of cell-free Hb. Up to now, COHb has been considered as a sink for both exogenous and endogenous CO generated during CO intoxication or heme metabolism, respectively. Hallmarking COHb as an important molecule with a biological (and eventually beneficial) role is a turning point in CO biology research, namely in CO intoxication and CO cytoprotection.DQ - Departamento de QuímicaUCIBIO - Applied Molecular Biosciences UnitInstituto de Tecnologia Química e Biológica António Xavier (ITQB)RUNCarrola, AndréRomão, Carlos C.Vieira, Helena L. A.2023-09-19T22:15:51Z2023-05-312023-05-31T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/other15application/pdfhttp://hdl.handle.net/10362/158007eng2076-3921PURE: 71916564https://doi.org/10.3390/antiox12061198info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T18:14:29Zoai:run.unl.pt:10362/158007Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:45:04.276858Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Carboxyhemoglobin (COHb)
Unavoidable Bystander or Protective Player?
title Carboxyhemoglobin (COHb)
spellingShingle Carboxyhemoglobin (COHb)
Carrola, André
carbon monoxide
carboxyhemoglobin
cytoprotection
hemoglobin
oxidative stress
Food Science
Physiology
Biochemistry
Molecular Biology
Clinical Biochemistry
Cell Biology
title_short Carboxyhemoglobin (COHb)
title_full Carboxyhemoglobin (COHb)
title_fullStr Carboxyhemoglobin (COHb)
title_full_unstemmed Carboxyhemoglobin (COHb)
title_sort Carboxyhemoglobin (COHb)
author Carrola, André
author_facet Carrola, André
Romão, Carlos C.
Vieira, Helena L. A.
author_role author
author2 Romão, Carlos C.
Vieira, Helena L. A.
author2_role author
author
dc.contributor.none.fl_str_mv DQ - Departamento de Química
UCIBIO - Applied Molecular Biosciences Unit
Instituto de Tecnologia Química e Biológica António Xavier (ITQB)
RUN
dc.contributor.author.fl_str_mv Carrola, André
Romão, Carlos C.
Vieira, Helena L. A.
dc.subject.por.fl_str_mv carbon monoxide
carboxyhemoglobin
cytoprotection
hemoglobin
oxidative stress
Food Science
Physiology
Biochemistry
Molecular Biology
Clinical Biochemistry
Cell Biology
topic carbon monoxide
carboxyhemoglobin
cytoprotection
hemoglobin
oxidative stress
Food Science
Physiology
Biochemistry
Molecular Biology
Clinical Biochemistry
Cell Biology
description Publisher Copyright: © 2023 by the authors.
publishDate 2023
dc.date.none.fl_str_mv 2023-09-19T22:15:51Z
2023-05-31
2023-05-31T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/other
format other
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/158007
url http://hdl.handle.net/10362/158007
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2076-3921
PURE: 71916564
https://doi.org/10.3390/antiox12061198
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 15
application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833596935170162688

Similar Items