Synthesis, Characterization and Photodynamic Activity against Bladder Cancer Cells of Novel Triazole-Porphyrin Derivatives

Bibliographic Details
Main Author: Gomes, Ana T. P. C.
Publication Date: 2020
Other Authors: Fernandes, Rosa, Ribeiro, Carlos F. M., Tomé, João P. C., Neves, Maria G. P. M. S., Silva, Fernando de C. da, Ferreira, Vítor F., Cavaleiro, José A. S.
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: https://hdl.handle.net/10316/106469
https://doi.org/10.3390/molecules25071607
Summary: Novel triazole-porphyrin derivatives (TZ-PORs) were synthesized through the Heck reaction and then incorporated into polyvinylpyrrolidone (PVP) micelles. After verifying that this incorporation did not compromise the photophysical and chemical features of TZ-PORs as photosensitizers, the phototoxicity of the formulations towards cancer cells was screened. Biological studies show high photodynamic activity of all PVP-TZ-POR formulations against a bladder cancer cell line with a particular highlight to PVP-TZ-POR 7e and 7f that are able to significantly reduce HT-1376 cell viability, while they had no effect on control ARPE-19 cells.
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spelling Synthesis, Characterization and Photodynamic Activity against Bladder Cancer Cells of Novel Triazole-Porphyrin Derivativesporphyrintriazolepolyvinylpyrrolidonephotodynamic therapyhuman bladder cancer cellshuman retinal pigment epithelial cellsNovel triazole-porphyrin derivatives (TZ-PORs) were synthesized through the Heck reaction and then incorporated into polyvinylpyrrolidone (PVP) micelles. After verifying that this incorporation did not compromise the photophysical and chemical features of TZ-PORs as photosensitizers, the phototoxicity of the formulations towards cancer cells was screened. Biological studies show high photodynamic activity of all PVP-TZ-POR formulations against a bladder cancer cell line with a particular highlight to PVP-TZ-POR 7e and 7f that are able to significantly reduce HT-1376 cell viability, while they had no effect on control ARPE-19 cells.The authors are grateful to University of Aveiro and FCT/MCT for the financial support for QOPNA research Unit (FCT UID/QUI/00062/2019) and LAQV-REQUIMTE (UIDB/50006/2020) through national funds. Thanks are also due to FCT/MCT for the financial support of iCBR and CIBB units (TDC/QEQQOR/1273/2012; UID/NEU/04539/2019 FCT UID/QUI/00062/2013) and CQE unit (UIDB/00100/2020), COMPETE-FEDER (POCI-01-0145-FEDER-007440) and Centro 2020 Regional Operational Programme: HEALTHYAGING 2020 (CENTRO-01-0145-FEDER-000012) for funding. Ana Gomes also thanks FCT for the post-doctoral grant (SFRH/BPD/79521/2011).MDPI2020-03-31info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://hdl.handle.net/10316/106469https://hdl.handle.net/10316/106469https://doi.org/10.3390/molecules25071607eng1420-3049322445141420-3049Gomes, Ana T. P. C.Fernandes, RosaRibeiro, Carlos F. M.Tomé, João P. C.Neves, Maria G. P. M. S.Silva, Fernando de C. daFerreira, Vítor F.Cavaleiro, José A. S.info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2023-04-06T10:20:12Zoai:estudogeral.uc.pt:10316/106469Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T05:57:13.112710Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Synthesis, Characterization and Photodynamic Activity against Bladder Cancer Cells of Novel Triazole-Porphyrin Derivatives
title Synthesis, Characterization and Photodynamic Activity against Bladder Cancer Cells of Novel Triazole-Porphyrin Derivatives
spellingShingle Synthesis, Characterization and Photodynamic Activity against Bladder Cancer Cells of Novel Triazole-Porphyrin Derivatives
Gomes, Ana T. P. C.
porphyrin
triazole
polyvinylpyrrolidone
photodynamic therapy
human bladder cancer cells
human retinal pigment epithelial cells
title_short Synthesis, Characterization and Photodynamic Activity against Bladder Cancer Cells of Novel Triazole-Porphyrin Derivatives
title_full Synthesis, Characterization and Photodynamic Activity against Bladder Cancer Cells of Novel Triazole-Porphyrin Derivatives
title_fullStr Synthesis, Characterization and Photodynamic Activity against Bladder Cancer Cells of Novel Triazole-Porphyrin Derivatives
title_full_unstemmed Synthesis, Characterization and Photodynamic Activity against Bladder Cancer Cells of Novel Triazole-Porphyrin Derivatives
title_sort Synthesis, Characterization and Photodynamic Activity against Bladder Cancer Cells of Novel Triazole-Porphyrin Derivatives
author Gomes, Ana T. P. C.
author_facet Gomes, Ana T. P. C.
Fernandes, Rosa
Ribeiro, Carlos F. M.
Tomé, João P. C.
Neves, Maria G. P. M. S.
Silva, Fernando de C. da
Ferreira, Vítor F.
Cavaleiro, José A. S.
author_role author
author2 Fernandes, Rosa
Ribeiro, Carlos F. M.
Tomé, João P. C.
Neves, Maria G. P. M. S.
Silva, Fernando de C. da
Ferreira, Vítor F.
Cavaleiro, José A. S.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gomes, Ana T. P. C.
Fernandes, Rosa
Ribeiro, Carlos F. M.
Tomé, João P. C.
Neves, Maria G. P. M. S.
Silva, Fernando de C. da
Ferreira, Vítor F.
Cavaleiro, José A. S.
dc.subject.por.fl_str_mv porphyrin
triazole
polyvinylpyrrolidone
photodynamic therapy
human bladder cancer cells
human retinal pigment epithelial cells
topic porphyrin
triazole
polyvinylpyrrolidone
photodynamic therapy
human bladder cancer cells
human retinal pigment epithelial cells
description Novel triazole-porphyrin derivatives (TZ-PORs) were synthesized through the Heck reaction and then incorporated into polyvinylpyrrolidone (PVP) micelles. After verifying that this incorporation did not compromise the photophysical and chemical features of TZ-PORs as photosensitizers, the phototoxicity of the formulations towards cancer cells was screened. Biological studies show high photodynamic activity of all PVP-TZ-POR formulations against a bladder cancer cell line with a particular highlight to PVP-TZ-POR 7e and 7f that are able to significantly reduce HT-1376 cell viability, while they had no effect on control ARPE-19 cells.
publishDate 2020
dc.date.none.fl_str_mv 2020-03-31
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/10316/106469
https://hdl.handle.net/10316/106469
https://doi.org/10.3390/molecules25071607
url https://hdl.handle.net/10316/106469
https://doi.org/10.3390/molecules25071607
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1420-3049
32244514
1420-3049
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833602528242040832

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